CATF: A Manager-Worker Framework for Context-Aware Time-Series Forecasting
Yueqiao Chen, Dongyu Liu
AI 速览：提出一种基于 Manager-Worker 架构的上下文感知时间序列预测框架，用 Transformer 经理按上下文硬路由到单个专家工人，使任意单模型预测器无需人工划分数据即可实现专业化。
We study context-aware time-series forecasting, in which a single target variable is predicted from its own history and a set of contextual variables, such as weather and calendar information. As the context becomes more diverse, a single model struggles to capture all of its regimes, while ensemble learning and Mixture-of-Experts approaches rely on manual data partitioning or soft routing, which increases the inference cost and hinders interpretability. We propose CATF, a Context-Aware Time-Series Forecasting framework built on a Manager-Worker architecture: a Transformer-based Manager routes each input to a single Worker based on the context, using hard routing during both training and inference. The Workers thus specialize without manual data partitioning, and any single-model forecaster can serve as a Worker. On five context-rich datasets, four horizons, and two normalization schemes, CATF improves over its standalone counterpart in 162 of 200 comparisons, the best CATF-enhanced model outperforms the best standalone baseline in 19 of 20 settings, and it outperforms the zero-shot Time-MoE foundation model in 15 of 20 settings. A case study on bike-sharing data shows that the Manager routes inputs by the calendar and that each Worker specializes in a different weekly pattern.
AI 速览：作者提出首个面向多模态有状态交互的大规模多轮对话数据集 YANAMI-400K 与评测基准 YANAMI-Bench，并报告微调 BAGEL 后在图像编辑、生成与有状态交互上均有提升。
Unified Multimodal Models (UMMs) integrate visual understanding, generation, and editing within a single unified framework. However, existing unified multimodal datasets and benchmarks remain dominated by single-turn tasks. Even in recent multi-turn datasets, many turns can be solved independently without tracking information across turns. Consequently, they provide limited supervision and evaluation for multimodal stateful interaction, which requires models to understand, maintain, update, and faithfully realize evolving dialogue states across turns. To address this gap, we introduce YANAMI, the first large-scale multimodal dialogue dataset and benchmark for stateful interaction, comprising YANAMI-400K and YANAMI-Bench. YANAMI-400K contains 400K multi-turn multimodal dialogues, with more than 2M images and 2.6M dialogue turns. The dialogues span four representative scenarios: Multi-Image Fusion, Image Editing, World Modeling, and Visual Reasoning, and require models to continuously track, preserve, and revise evolving multimodal dialogue states across turns. YANAMI-Bench comprises 400 multi-turn dialogues for systematically evaluating multimodal stateful interaction. It jointly evaluates Dialogue State Understanding and Visual Realization, characterizing the gap between models' ability to understand evolving dialogue states and their ability to faithfully realize them in visual outputs. Experiments show that fine-tuning BAGEL on YANAMI-400K improves image editing, generation, and multimodal stateful interaction by 10.3%, 2.0%, and 13.23%, respectively, while preserving its general visual understanding capabilities. Evaluations on YANAMI-Bench further reveal that existing UMMs still struggle to maintain, update, and visually realize evolving multimodal dialogue states.
iGC: Antibody Optimization via Reinforcement Learning over a Learned Somatic Hypermutation Prior
Thao Nguyen, Robert G. Alberstein, Ewa Nowara, Homa MohammadiPeyhani, Holly R. Steach, Sarah A. Robinson, Yuval Shechter, Donald W. Lee 等 13 位作者
AI 速览：iGC 是一个两阶段强化学习框架，先学习体细胞超突变先验，再在抗原特异性亲和力优化中结合 KL 正则与奖励税元梯度，以兼顾生物学合理的突变与结合优化。
Antibody affinity maturation is a natural optimization process in which B cells acquire mutations through somatic hypermutation (SHM), undergo selection for improved antigen binding, and iteratively evolve toward higher affinity. Computationally modeling this process requires capturing both biologically plausible mutations and antigen-specific selection. However, existing mutation models do not directly optimize binding, while affinity optimization often neglects realistic mutation trajectories. We introduce iGC (in silico Germinal Centers), a two-stage reinforcement learning (RL) framework for antigen-specific antibody optimization. Stage 1 learns an SHM mutation prior from parent-child pairs in B-cell lineage trees and adapts it to a target affinity-maturation dataset. Stage 2 initializes an RL policy from this prior and optimizes antigen binding with Kullback-Leibler (KL) regularization toward the frozen prior. To prevent reward exploitation, including repetitive high-reward substitutions and structurally tolerated framework mutations, we introduce a Reward-Tax Meta-Gradient objective. RewardNet smooths the affinity landscape, while TaxNet penalizes reward overexploitation, jointly defining a learned meta-reward for policy optimization. We evaluate iGC on mutation prediction, SHM consistency, affinity optimization, and mutation diversity. The mutation prior more than doubles the strongest baseline in mutation-site prediction. Following RL optimization, iGC maintains SHM sequence structure. It also achieves a strong exploration-exploitation balance, yielding competitive reward-diversity products across candidate-selection cutoffs. These results demonstrate that iGC integrates biologically plausible mutation generation with antigen-specific affinity selection, providing an in silico framework for iterative antibody affinity maturation.
Continuous-Action World Models: Learning Cross-Embodiment Spatiotemporal Dynamics Priors
Liangyu Li, Qingwen Liu
AI 速览：提出 CoAWM 框架，通过共享潜在函数空间学习跨具身、跨执行频率的机器人动作时空动力学先验，以支持动作生成。
We introduce Continuous-Action World Models (CoAWM), a framework for learning cross-embodiment spatiotemporal dynamics priors that support robot action generation across embodiments and execution frequencies. At its core is a shared latent function space that captures the spatial and temporal structure of robot actions. We learn this space through two stages. First, function pretraining brings trajectories from different embodiments and sampling frequencies into a common representation, learning shared dynamics priors through action reconstruction and consistency across temporal sampling views. By accommodating heterogeneous robot trajectories, this stage broadens the range of data sources available for pretraining and facilitates scaling to larger and more diverse datasets. Second, we connect the pretrained function space to a world-model backbone, enabling observations, language instructions, and the current robot state to condition the prediction of a latent action function. A single decoder takes any query time and returns the corresponding end-effector action. By separating shared dynamics priors from task-conditioned action selection and temporal sampling, our approach provides a unified foundation for transferring robot experience across embodiments and control frequencies.
AI 速览：作者重新审视量化误差导致语义损失的假设，提出有效比特预算才是关键，并引入因子化向量量化（FVQ）使离散表示在多模态理解上媲美连续表示。
Discrete visual tokens represent vision in a discrete form analogous to language, offering a native interface for multimodal modeling under a shared next-token prediction objective. However, quantization error is widely assumed to cause unavoidable semantic loss, fundamentally limiting the semantic fidelity of discrete visual tokens and positioning continuous visual representations as an intrinsic upper bound. Using multimodal understanding as a proxy for semantic fidelity, we revisit this assumption and find quantization error unreliable, as discrete representations with substantially larger errors can achieve better understanding. Instead, the effective bit budget of discrete indices emerges as a key determinant of downstream performance. However, existing quantizers eventually saturate as additional codebooks contribute progressively less semantic information. As one approach to alleviating this saturation, we introduce Factorized Vector Quantization, which quantizes complementary, fixed-dimensional views of the visual feature with symmetric parallel codebooks. It continues to improve at larger bit budgets, ultimately matching continuous visual representations in multimodal understanding. Trained on industrial-scale multimodal data, our model achieves state-of-the-art performance among discrete-representation models, outperforming UniAR and Emu3-Chat by 22.8% and 59.2%, respectively, on a nine-metric average. To our knowledge, it is also the first discrete-representation model competitive with strong continuous-representation models such as Qwen3-VL, including on fine-grained OCR tasks. We further identify the key principles and a practical recipe enabling this competitiveness. These results and insights support the potential of discrete visual representations to underpin large-scale native multimodal foundation models. Code and models are available at https://github.com/hustvl/FVQ