Doniyorkhon Obidov, Xiaolong Guo, Yonghui Li, Kaichen Yang
Large Language Models (LLMs) have accelerated drug discovery, particularly in the automated design of antimicrobial peptides (AMPs). However, current validation pipelines for peptide generation models overlook historical precedents showing that certain drugs carry health risks predominantly for individuals with specific genetic profiles. In this paper, we demonstrate that such targeted health risks can be induced intentionally and at scale by manipulating models that generate peptide candidates. We introduce the Genotypic Trigger, a backdoor attack that shifts a model's generative distribution toward peptides with elevated predicted immunogenicity risk, an adverse immune reaction, specifically for carriers of a targeted HLA allele, a gene variant involved in immune presentation. Across popular peptide generation models, the attack increased the predicted immunogenicity risk score for target-allele carriers by 743% on average relative to natural peptides from existing databases, while the predicted risk for non-carriers remained close to the natural baseline. Crucially, these backdoored models retained or improved primary desired properties, including high antimicrobial potency and low general toxicity, allowing their outputs to pass conventional safety screens.
Doniyorkhon Obidov, Honggang Yu, Xiaolong Guo, Kaichen Yang
Low-rank adaptation (LoRA) enables efficient specialization and distribution of large language models through compact adapters. However, untrusted adapters introduce a supply-chain threat: a backdoored adapter can cause a model to generate harmful content, malicious code, political propaganda, or covert advertisements when an input contains a hidden trigger. Adapter-agnostic defenses merge the adapter with the base model, which dilutes backdoor signals and reduces detection performance. Existing adapter-aware methods do not address how to safely use a potentially backdoored adapter. Instead, they either train a defensive adapter to repair a backdoored base model, addressing the inverse problem rather than securing the adapter itself, or rely on a classifier that flags the entire adapter as suspicious and requires separate mitigation. These methods overlook the distinct latent-space signatures produced by trigger-bearing inputs in backdoored adapters. We introduce LoRAScan, the first adapter-aware defense that detects and rejects trigger-bearing inputs at inference time without modifying adapter parameters. Our key observation is that a small subset of LoRA insertion sites, approximately 5%, remains stable across clean inputs but exhibits highly concentrated spikes in LoRA down-projection activations when a trigger is present. LoRAScan identifies these low-variance insertion sites before model deployment and monitors them during inference. Across standard LLM backdoor benchmarks, LoRAScan rejects 98.49% of malicious inputs with a small error rate on clean inputs, outperforming existing defenses across diverse evaluation settings.
Chen Yang, Ruping Xu, Ruizhe Li University of Aberdeen, Bin Cao Zhejiang University of Technology, Jing Fan Zhejiang University of Technology
Extracting structured procedural knowledge from unstructured business documents is a critical yet unresolved bottleneck in process automation. While prior work has focused on extracting linear action flows from instructional texts (e.g., recipes), it has insufficiently addressed the complex logical structures—such as conditional branching and parallel execution—that are pervasive in real-world regulatory and administrative documents. Furthermore, existing benchmarks are limited by simplistic schemas and shallow logical dependencies, restricting progress toward logic-aware large language models (LLMs). To bridge this “Logic Gap”, we introduce \textbf{BREX}, a carefully curated benchmark comprising 409 real-world business documents and 2,855 expert-annotated rules. Unlike prior datasets centered on narrow service scenarios, BREX spans over 30 vertical domains, covering scientific, industrial, administrative, and financial regulations.We further propose \textbf{ExIde}, a structure-aware reasoning framework that investigates five distinct prompting strategies, ranging from implicit semantic alignment to executable grounding via pseudo-code generation, enabling explicit modeling of rule dependencies and providing an out-of-the-box framework for different business customers without finetuning their own LLMs. We benchmark ExIde using 13 state-of-the-art LLMs. Our extensive evaluation reveals that: (1) Executable grounding serves as a superior inductive bias, significantly outperforming standard prompts in rule extraction; and (2) Reasoning-optimized models demonstrate a distinct advantage in tracing long-range dependencies and non-linear rule dependencies compared to standard instruction-tuned models.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Connor Baumler University of Maryland, College Park, Calvin Bao, Huy Nghiem, Xinchen Yang, Marine Carpuat University of Maryland, College Park, Hal Daumé Iii University of Maryland, College Park
Despite the growing use of large language models (LLMs) for writing tasks, users may hesitate to rely on LLMs when personal style is important. Post-editing LLM-generated drafts or translations is a common collaborative writing strategy, but it remains unclear whether users can effectively reshape LLM-generated text to reflect their personal style. We conduct a pre-registered online study (n=81) in which participants post-edit LLM-generated drafts for writing tasks where personal style matters to them. Using embedding-based style similarity metrics, we find that post-editing increases stylistic similarity to participants’ unassisted writing and reduces similarity to fully LLM-generated output. However, post-edited text still remains stylistically closer in style to LLM text than to participants’ unassisted control text, and it exhibits reduced stylistic diversity compared to unassisted human text. We find a gap between perceived stylistic authenticity and model-measured stylistic similarity, with post-edited text often perceived as representative of participants’ personal style despite remaining detectable LLM stylistic traces.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Yifan Wang, Shiyu Li Tencent, Peiming Li, Xiaochen Yang University of Glasgow, Zheng Wei Tencent Technology (Beijing) Company Limited, Yang Tang Tencent
Chain-of-Thought (CoT) prompting has achieved remarkable success in unlocking the reasoning capabilities of Large Language Models (LLMs). Although CoT prompting enhances reasoning, its verbosity imposes substantial computational overhead. Recent works often focus exclusively on outcome alignment and lack supervision on the intermediate reasoning process. These deficiencies obscure the analyzability of the latent reasoning chain. To address these challenges, we introduce Render-of-Thought (RoT), the first framework to reify the reasoning chain by rendering textual steps into images, making the latent rationale explicit and traceable. Specifically, we leverage the vision encoders of existing Vision Language Models (VLMs) as semantic anchors to align the vision embeddings with the textual space. This design ensures plug-and-play implementation without incurring additional pre-training overhead. Extensive experiments on mathematical and logical reasoning benchmarks demonstrate that our method achieves 3-4\times token compression and substantial inference acceleration compared to explicit CoT. Furthermore, it demonstrates a competitive efficiency-accuracy Pareto exploration compared to other methods, validating the feasibility of this paradigm. Our code is available at https://github.com/TencentBAC/RoT
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cs.CL · cs.CV
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表