Chien Van Nguyen University of Oregon, Huy Huu Nguyen, Ruiyi Zhang, Hanieh Deilamsalehy Adobe Systems, Puneet Mathur Adobe Systems, Viet Dac Lai Adobe Systems, Haoliang Wang Adobe Research, Jayakumar Subramanian Adobe Systems 等 13 位作者
We propose Lizard, a linearization framework that transforms pretrained Transformer-based Large Language Models (LLMs) into subquadratic architectures. Transformers faces severe computational and memory bottlenecks with long sequences due to the quadratic complexity of softmax attention and the growing Key-Value (KV) cache that makes inference memory-bound by context length. Lizard addresses these limitations by introducing a subquadratic attention mechanism that closely approximates softmax attention while preserving model quality. Unlike prior linearization methods constrained by fixed, non-adaptive structures, Lizard augments the architecture with compact, learnable modules that enable adaptive memory control and robust length generalization. Moreover, we introduce a hardware-aware algorithm that solves numerical instability in gated attention to accelerate training. Extensive experiments show that Lizard achieves near-lossless recovery of its teacher model’s performance, significantly outperforming previous methods by up to 9.4 - 24.5 points on the 5-shot MMLU benchmark and demonstrating superior associative recall.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Xin Gao, Ruiyi Zhang University of California, San Diego, Meixi Du, Peijia Qin, Pengtao Xie University of California, San Diego
Despite the success of large language models (LLMs) on general-purpose tasks, their performance in highly specialized domains such as biomedicine remains unsatisfactory. A key limitation is the inability of LLMs to effectively leverage biomedical tools, which clinical experts and biomedical researchers rely on extensively in daily workflows. While recent general-domain tool-calling datasets have substantially improved the capabilities of LLM agents, existing efforts in the biomedical domain largely rely on in-context learning and restrict models to a small set of tools. To address this gap, we introduce BioTool, a comprehensive biomedical tool-calling dataset designed for fine-tuning LLMs. BioTool comprises 34 frequently used tools collected from the NCBI, Ensembl, and UniProt databases, along with 7,040 high-quality, human-verified query–API call pairs spanning variation, genomics, proteomics, evolution, and general biology. Fine-tuning a 4-billion-parameter LLM on BioTool yields substantial improvements in biomedical tool-calling performance, outperforming cutting-edge commercial LLMs such as GPT-5.1. Furthermore, human expert evaluations demonstrate that integrating a BioTool-fine-tuned tool caller significantly improves downstream answer quality compared to the same LLM without tool usage, highlighting the effectiveness of BioTool in enhancing the biomedical capabilities of LLMs. The full dataset and evaluation code are available at https://github.com/gxx27/BioTool.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Rui Wang Adobe Systems, Junda Wu University of California, San Diego, Yu Xia University of California, San Diego, Tong Yu Adobe Research, Ruiyi Zhang, Ryan A. Rossi, Subrata Mitra Adobe Systems, Lina Yao University of New South Wales 等 9 位作者
Large Language Models (LLMs) are susceptible to indirect prompt injection attack, where the model inadvertently responds to instructions injected into the prompt context. This vulnerability stems from LLMs’ inability to distinguish between data and instructions within a prompt. We propose CachePrune that defends against this attack by identifying and pruning neurons associated with instruction-following, during KV cache encoding of the prompt context. The pruning steers the LLM toward interpreting the context purely as data rather than as instructions to follow. To identify these neurons, we introduce a neural attribution mechanism guided by a preferential attribution loss, and theoretically connect this loss to an upper bound of the Direct Preference Optimization (DPO) objective. Further, we improve on the fidelity of neural attribution by leveraging an observed triggering effect in instruction-following. Our approach does not interfere with prompt formatting or incur test-time overhead in response generation. Experiments show that CachePrune significantly reduces the attack success rate while preserving the LLM’s ability to follow user instructions.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表