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The extent to which demographic-associated information is detectable across organs and disease states in routine clinical histopathology remains unclear. Here, we analyzed 1.3 million hematoxylin and eosin whole-slide images from 257,322 patients across 25 organs, using pathology foundation-model representations and multiple-instance learning to systematically map information associated with sex, age group, and self-reported race. Across 69 organ-demographic combinations, demographic attributes were broadly recoverable, with pan-organ mean AUROCs of 0.828 for sex, 0.733 for age group, and 0.662 for self-reported race, and substantial variation across organs. Demographic-class balancing produced relatively small changes in performance, while evaluation within diagnosis-text clusters showed modest attenuation. Under training with diagnosis-based grouping, demographic-associated signals remained detectable across multiple organs, including sex in gastric tissue (AUROC 0.865), age group in breast (0.816), and self-reported race in skin (0.728). Literature-guided analysis of these settings generated candidate histomorphological and contextual explanations for further investigation. Together, these findings provide a systematic map of demographic-associated information in routine histopathology, informing investigations of its sources, assessments of potential shortcut learning, and the development of more interpretable computational pathology models.

Modern diffusion models are trained on massive datasets that often include copyrighted or private images. Membership inference attacks (MIAs) address this by testing whether a given image was in a model's training set. The standard approach scores an image by its reconstruction loss and flags low-loss images as members. This often fails because some images are simply easier to reconstruct than others, so a simple unseen image can score a lower loss than a complex training image. Difficulty calibration separates memorization from how difficult an image is to begin with. We show how to calibrate along two axes of time: training time and diffusion time. First, across training time, we introduce Reference-Model Calibration (RMC), which compares a fine-tuned model's loss against an earlier checkpoint. This cleanly isolates newly memorized data and gives near-perfect auditing, even without text captions. Since earlier checkpoints are not always available, we next present Temporal Self-Calibration (TSC), which calibrates across diffusion time using only a single model. Our key observation is that an image's difficulty persists across noise levels, whereas memorization is localized in time. By comparing the loss at a target timestep against neighboring timesteps from the same model, TSC attenuates image difficulty using the model's own trajectory. Empirically, our methods beat the state of the art by a wide margin, and unlike most existing attacks, generalize across different model parameterizations such as $x$-, $v$-, and $ε$-prediction models. Code is available at https://github.com/MichaelJoseph777/TSC.