Shuijin Lin, Shaozhen Yan, Tuo Liu, Haifeng Wang, Chunfeng Lian, Jie Lu, Jianhua Ma, Lin Xie
The biological definition of Alzheimer's disease (AD) relies on multi-modal neuroimaging, yet the clinical utility of positron emission tomography (PET) is limited by cost and radiation exposure, hindering early screening at preclinical or prodromal stages. While generative models offer a promising alternative by synthesizing PET from magnetic resonance imaging (MRI), achieving subject-specific precision remains a primary challenge. Here, we introduce DIReCT$++$, a Domain-Informed ReCTified flow model for synthesizing multi-tracer PET from MRI combined with fundamental clinical information. Our approach integrates a 3D rectified flow architecture to capture complex cross-modal and cross-tracer relationships with a domain-adapted vision-language model (BiomedCLIP) that provides text-guided, personalized generation using clinical scores and imaging knowledge. Extensive evaluations on multi-center datasets demonstrate that DIReCT$++$ not only produces synthetic PET images ($^{18}$F-AV-45 and $^{18}$F-FDG) of superior fidelity and generalizability but also accurately recapitulates disease-specific patterns. Crucially, combining these synthesized PET images with MRI enables precise personalized stratification of mild cognitive impairment (MCI), advancing a scalable, data-efficient tool for the early diagnosis and prognostic prediction of AD. The source code will be released on https://github.com/ladderlab-xjtu/DIReCT-PLUS.
Jiafeng Liang, Xianhao Ou, Tao Ren, Rongchuan Mu, Runxuan Liu, Dandan Tu, Ming Liu, See-Kiong Ng 等 9 位作者
Reinforcement learning with verifiable rewards (RLVR) has emerged as an effective post-training paradigm for enhancing the video reasoning capability of Large Multimodal Models (LMMs). Despite its empirical effectiveness, we show that outcome-level optimization can introduce an undesirable shortcut amplification effect, whereby models increasingly favor text-prior answers even when they are not supported by the visual evidence. To characterize this behavior, we investigate the training dynamics of video RLVR through the lens of perceptual uncertainty, analyzing how predictive uncertainty evolves under video-conditioned and text-only contexts. Our analysis identifies a perceptual uncertainty collapse phenomenon, in which RL training continuously sharpens the model's answer distribution while the uncertainty reduction attributable to visual evidence progressively diminishes. A further gradient-direction analysis reveals that such confidence enhancement becomes increasingly less aligned with visually grounded uncertainty reduction and is instead dominated by text-prior compression. Motivated by these findings, we propose Bifocal Self-distillation Policy Optimization (BSPO), a self-distillation framework that regulates policy updates with two complementary distributional signals. Specifically, BSPO derives empirical reasoning principles from intra-group correct and incorrect rollouts to identify reasoning-sensitive tokens, and introduces shortcut-aware visual perturbation to penalize predictions that remain invariant when task-relevant visual evidence is weakened. By adaptively reweighting the original RL advantage, BSPO preserves the task-solving benefits of RLVR while promoting updates that are both reasoning-sensitive and visually grounded. Extensive experiments validate the effectiveness of BSPO in improving video reasoning performance and strengthening visual faithfulness.
Chao-Yeh Chen, Tiffany Chen, Lin Duan, Tianyi Hu, Yu-Hsiang Huang, Umar Iqbal, Jiefeng Li, Edy Lim 等 15 位作者
We introduce EgoHand, a monocular 3D hand reconstruction model that achieves state-of-the-art performance on egocentric video. Central to our approach is the curation of a high-quality training corpus of 14 million images, combining synthetic data, in-the-wild video, and multi-camera motion capture to balance scene diversity and supervision quality. The model adopts SOMA-Hand as its parametric representation and processes 2D hand crops with a transformer encoder, incorporating camera cues and an auxiliary 2D branch to improve geometric consistency and image alignment. Zero-shot evaluations on HOT3D, ARCTIC, and H2O demonstrate strong out-of-domain generalization, with lower joint-position, root-translation, and acceleration errors than competing baselines at an inference latency of approximately 9.01 ms. A blinded user preference study further shows that participants favor EgoHand's reconstructed hand poses over those from Apple EgoDex and Ropedia Xperience-10M. We release the EgoHand model and source code under the OpenMDW license, allowing free commercial use of the model.
Shifang Zhao, Long Bai, Kun Yuan, Feng Li, Jieming Yu, Wenzhen Dong, Guankun Wang, Mobarakol Islam 等 11 位作者
In surgical instrument segmentation, the increasing variety of instruments over time poses a significant challenge for existing neural networks, as they are unable to effectively learn such incremental tasks and suffer from catastrophic forgetting. When learning new data, the model experiences a sharp performance drop on previously learned data. Although several continual learning methods have been proposed for incremental understanding tasks in surgical scenarios, the issue of data imbalance often leads to a strong bias in the segmentation head, resulting in poor performance. Data imbalance can occur in two forms: (i) class imbalance between new and old data, and (ii) class imbalance within the same time point of data. Such imbalances often cause the dominant classes to take over the training process of continual semantic segmentation (CSS). To address this issue, we propose SurgCSS, a novel plug-and-play CSS framework for surgical instrument segmentation under data imbalance. Specifically, we generate realistic surgical backgrounds through inpainting and blend instrument foregrounds with the generated backgrounds in a class-aware manner to balance the data distribution in various scenarios. We further propose the Class Desensitization Loss by employing contrastive learning to correct edge biases caused by data imbalance. Moreover, we dynamically fuse the weight parameters of the old and new models to achieve a better trade-off between the biased and unbiased model weights. To investigate the data imbalance problem in surgical scenarios, we construct a new benchmark for surgical instrument CSS by integrating datasets. Extensive experiments demonstrate the effectiveness of the proposed framework, achieving significant performance improvement against existing baselines.
YiFan Zhang, Tao Yu, Feng Li, Chaoyou Fu Nanjing University, Yibo Hu Taobao, Kun Wang, Qingsong Wen, Zhang Zhang Institute of automation, Chinese academy of science, Chinese Academy of Sciences 等 10 位作者
The supervised fine-tuning (SFT) stage is crucial for multimodal large language models (MLLMs), yet a comprehensive scaling law to guide the optimal model-data configuration remains lacking. In this paper, we make an initial attempt to address this gap. First, we theoretically demonstrate that directly computing the optimal computation frontier for MLLM-SFT, as we can for traditional LLMs, is a challenging task. This complexity arises because MLLM-SFT is influenced by a broader range of factors, including model size, LLM pre-training tokens, and MLLM SFT tokens. To tackle this issue, we propose two scaling laws based on LLM paradigms: one applicable when training data volumes are well defined by researchers, and another for cases where models are sourced from open communities with unknown training data. Through theoretical modeling and approximations, we provide researchers with valuable recommendations for optimal resource allocation. Furthermore, we establish a strong correlation ( R^2 = 0.98) between training loss and downstream performance, enabling accurate performance estimation without the need for exhaustive benchmarking. To validate our scaling laws, we construct a testbed of 60 models ranging from 50 million to 8 billion parameters, totaling 1,560 checkpoints. Each checkpoint is evaluated on than 10 MLLM benchmarks, ensuring robust fitting of our formulations.
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cs.CL · cs.CV
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表