Spatial transcriptomics (ST) enables joint characterization of tissue morphology and gene expression. However, 3D volumetric ST acquisition remains expensive. AI-driven methods offer a low-cost alternative but remain limited in accuracy, while recent 2D section-wise ST acquisition still rely on dense grid sampling, resulting in redundant measurements and undersampling of biologically informative regions. To bridge the gap, we propose STRATA, a reinforcement-driven active sampling framework with tri-paradigm adaptation for reconstructing dense 3D transcriptomic maps from sparse voxel-wise ST acquisition. STRATA constructs a 3D graph integrating H&E morphology with single-cell priors and employs a reinforcement learning agent to estimate morphological sparsity and transcriptomic informativeness, enabling budget-aware selection of informative spots. Given these sparse measurements, an adaptive tri-paradigm predictor combines retrieval, regression, and cross-layer imputation through lightweight fusion, dynamically weighting their contributions. Experiments across datasets demonstrate improved sampling efficiency and accuracy, particularly under low-budget settings. Code is available at https://github.com/Junchao-Zhu/STRATA.
Cui Yakun The Hong Kong University of Science and Technology, Peng Qi Centre for Trusted Internet and Community, National University of Singapore, Fushuo Huo The Hong Kong University of Science and Technology, Hang Du Beijing University of Posts and Telecommunications, Weijie Shi Hong Kong University of Science and Technology, Juntao Dai Peking University, Zhenghao Zhu, Sirui Han The Hong Kong University of Science and Technology
The advent of multi-modal large language models (MLLMs) has greatly advanced research on video fake news detection (VFND) tasks. Existing benchmarks typically focus on the detection accuracy, while failing to provide fine-grained assessments for the entire detection process. To address these limitations, we introduce POVFNDB (Process-oriented Video Fake News Detection Benchmark), a process-oriented benchmark comprising 10 tasks designed to systematically evaluate MLLMs’ perception, understanding, and reasoning capabilities in VFND. This benchmark contains 36,240 human-annotated question-answer (QA) in structured or open-ended formats, spanning 15 distinct evaluation dimensions that characterize different aspects of the video fake news detection process.Using POVFNDB, we conduct comprehensive evaluations on both proprietary and open-source MLLMs. Moreover, We fine-tune Qwen2.5VL-7B-Instruct on a reasoning dataset generated by our proposed POVFND-CoT, a chain-of-thought method that utilizes rationales from evaluation results and rationale validation. The resulting model achieves sota performance on VFND.
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cs.CL · cs.CV
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表