基于潜在ODE的心室全心动周期运动建模:从电影MRI到心衰风险预测
A latent ODE approach to full-cycle biventricular cardiac motion modeling from cine MRI
David Brüggemann, Ekaterina Krymova, Firat Özdemir, Jochen von Spiczak, Sebastian Kozerke, Samia Mora, Robert Manka, Mathieu Salzmann 等 9 位作者
AI 速读 基于摘要
作者提出一种结合心率感知神经常微分方程与图网格自编码器的潜在动力学模型,将双心室全心动周期电影MRI运动编码为连续潜在轨迹,并检验其偏离协变量条件先验能否预测新发心力衰竭。
cs.AI · cs.CV
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Cardiac magnetic resonance imaging (CMR) captures rich spatiotemporal information about ventricular structure and motion, but conventional risk models use only a few image-derived indices from selected cardiac phases. We present a latent dynamical model that encodes bi-ventricular anatomy and full-cycle cine motion as a continuous latent trajectory, using heart-rate-aware neural ordinary differential equation (ODE) dynamics and a graph-based mesh autoencoder to reconstruct anatomically consistent 3D+t ventricular motion. A covariate-conditioned prior defines the expected end-diastolic latent state, and a Cox proportional hazards model tests whether deviations from this prior predict incident heart failure. We studied 72,386 UK Biobank participants without baseline cardiovascular disease, including 367 incident heart failure events. In a held-out evaluation subset, adding the latent score to refitted pooled cohort equations improved the stratified C-index from 0.704 to 0.785, compared with 0.764 for seven established cardiac markers. Compared with non-graph and non-ODE approaches, the proposed model gave the best trade-off between reconstruction fidelity, generative realism, and downstream prognostic performance. These results suggest that continuous full-cycle modeling of ventricular motion provides informative cardiac phenotypes beyond conventional CMR summaries, while external validation in more representative patient cohorts is required before clinical risk-prediction use.