论文库

Fetal brain biometry provides a quantitative basis for assessing prenatal growth and identifying congenital brain abnormalities. However, comprehensive assessment remains limited by labor-intensive manual measurements and automated models that lose accuracy across imaging sequences and institutions. We introduce BioTTA, an anatomically guided test-time adaptation framework that measures 11 fetal brain biometrics from reconstructed three-dimensional magnetic resonance images. BioTTA adapts pretrained models to individual unlabeled volumes using geometric consistency and atlas priors, without access to source images. In a retrospective study across five centers in China and Switzerland, BioTTA improved measurement accuracy across three out-of-distribution datasets and two network architectures. It reduced mean absolute measurement errors by 46-82% relative to the corresponding models without adaptation, achieving errors similar to those of supervised fine-tuning. Its measurements were mapped onto normative growth trajectories derived from expert annotations, enabling gestational-age-specific assessment through a web-based reporting platform. Across four disease cohorts, the platform achieved 82.1-95.0% accuracy in binary detection of ventriculomegaly or cerebellar abnormalities, with performance similar to that of a senior radiologist. BioTTA provides a practical foundation for standardized fetal brain biometry across heterogeneous imaging settings, supporting scalable prenatal growth assessment and quantitative evaluation of brain abnormalities.

Automatic tools can now generate whole-brain MRI parcellations at cohort scale, but generated-label releases often provide little evidence about which cases are reliable enough to reuse. We introduce OpenBrain, a confidence-aware release of 35,838 provenance-verified OpenNeuro T1w cases from 607 source datasets. OpenBrain is organized as an auditable case-record release rather than a directory of standalone segmentation files: each record links a primary parcellation, two committee parcellations, source/license provenance, raw QC-7 measurements, percentile risks, a combined risk score R, and a confidence tier. QC-7 is a reference-free reliability panel over label geometry, image-label consistency, and committee disagreement, so users can filter, weight, audit, or re-threshold generated labels without rerunning inference. We evaluate this released evidence under a frozen protocol. Across external cohorts, lower QC-7 risk corresponds to higher generated-label quality; in fixed-budget training, lower-risk selections improve paired macro Dice over random selection by +3.2 to +3.7 percentage points. OpenBrain also exposes raw axes, committee outputs, provenance, and datasheet documentation, so confidence claims remain inspectable after download. It does not turn generated labels into manual annotations or clinical-grade segmentations. Its contribution is a large open generated-parcellation substrate, a reusable case-level risk-evidence layer, and an external validation protocol for release-time QC. Dataset: https://huggingface.co/datasets/lanqz7766/OpenBrain. Code: https://github.com/lanqz7766/openbrain.