Missing-sequence completion is important for comprehensive brain tumor characterization, but cross-modal fusion can obscure sequence-specific contrast and lose fine-grained three-dimensional tumor detail. To address this challenge, we introduce Modality-aware Orthogonal-axis Status-conditioned Attentive Integration for Completion (MOSAIC-Flow), a unified framework for missing-sequence completion that learns a target-conditioned velocity field while keeping the seven acquired volumes fixed throughout the transport. Specifically, modality-aware stems independently encode each sequence, and orthogonal-axis refinement captures axial, coronal, and sagittal dependencies while retaining the three-dimensional representation. Status-conditioned prototype fusion uses compact modality and availability tokens to route and modulate pooled queries from the fused visual representation, enabling target-adaptive conditioning without dense voxel-to-voxel attention. A conditional flow matching objective transports target-channel noise toward the single missing sequence, while four Heun trajectories are averaged to produce the completion. Evaluation across structural, diffusion, and contrast-enhanced MRI in UCSF-PDGM demonstrates consistent whole-brain and tumor-region fidelity across all eight single-target completion tasks, with the strongest performance on structural sequences. Code is available at https://github.com/CUHK-AIM-Group/MOSAIC-FLOW.
Alzheimer's disease (AD) diagnosis may benefit from gut metabolic information associated with brain-gut interactions, yet existing models largely analyze cerebral glucose metabolism alone. Although whole-body fluorodeoxyglucose positron emission tomography (FDG-PET) can provide paired brain-gut observations, routine brain examinations rarely include gut imaging, limiting direct use of this information for diagnosis. In this paper, we present BRIDGE (Brain and Gut Representation Integration via Distribution-Guided Enhancement), a two-stage framework for transferring brain-gut metabolic knowledge to brain-only diagnosis. Specifically, BRIDGE integrates a conditional brain-to-gut latent transport module and a disease-evidence-guided cerebral pathway to capture subject-specific cross-organ correspondence and disease-relevant cerebral representations. For the cerebral pathway, a large language model (LLM) helps organize literature-derived descriptors into human-approved semantic anchors that guide feature learning. Additionally, we introduce a counterfactual-guided residual fusion mechanism, which uses matched and non-matched virtual-gut evidence to supervise a confidence gate and dynamically regulate the contribution of transported cross-organ information. At inference, BRIDGE exploits complementary gut-related context using brain PET alone, without measured gut PET. Extensive experiments across public and private cohorts demonstrate that BRIDGE outperforms brain-only and cross-organ baselines, achieving AUC gains of 6.0% and 5.2% over its brain-only counterpart for CN/MCI and CN/AD diagnosis, respectively. Notably, its ability to transfer complementary brain-gut metabolic context while preserving brain PET as the sole inference input highlights its potential for clinically practical diagnosis. Our code is available at https://github.com/CUHK-AIM-Group/BRIDGE.
Image editing models can modify visual content through natural language, but editing dense documents requires precise local changes amid tightly coupled text, tables, and layout. We introduce VDE Bench, an evaluation resource for studying instruction-guided editing of Chinese and English document images. VDE Bench contains 3,506 instruction-guided image editing samples, including 1,578 text-region edits and 1,928 table-region edits. The benchmark pairs editing instructions and reference images with annotated editing regions and structured OCR outputs. Its evaluation protocol combines region-level and full-page measurements to assess textual correctness, structural fidelity, and visual content preservation. By focusing on the interaction between local edits and their surrounding document context, VDE Bench complements existing visual text editing benchmarks and provides a resource for diagnosing document-specific editing failures.
Chenyang Fan, Robert D. Sanders, Elie Matar, Yixuan Yuan, Xiang Li, Sharon L. Naismith, Fernando Calamante, Jinglei Lv
Diffusion MRI (dMRI) provides information about white matter microstructure that can support brain age prediction. However, many existing prediction models use diffusion tensor imaging (DTI) scalar metrics that omit orientation information. Deep learning is increasingly used for brain age prediction, but conventional CNNs do not explicitly respect the geometric structure of orientation-dependent features. We present an interpretable brain age prediction framework that combines white matter fiber orientation distributions (WM-FODs) with an SE(3) (Special Euclidean group in 3 dimensions) equivariant CNN. The network operates directly on spherical harmonic (SH) coefficients of the FOD, preserving their transformation properties under rotation. Evaluation in 692 participants aged 36-90 years from the Human Connectome Project Aging dataset showed that the combined framework outperformed the evaluated DTI-based models and conventional CNNs. Averaging predictions from five cross-validation models yielded a mean absolute error of 3.54 years and Pearson's correlation of 0.958. Our results indicated that the performance advantage depended on combining WM-FODs with equivariant processing. Prediction accuracy was highest at a maximum SH order of Lmax = 2 and declined at higher orders. Tract-level occlusion, where each segmented tract was masked in turn, revealed age-dependent patterns of model sensitivity, with importance peaks in frontal projection pathways at 36-44 years, the fornix at 45-54 years, the callosal isthmus at 55-64 years, the middle cerebellar peduncle at 65-74 years, and the callosal genu at 75-90 years. These findings support rotation-equivariant processing of WM-FODs for accurate brain age prediction with anatomically interpretable model sensitivity.