Xing Liu, Yifan Guo, Hongtai Lv, Lei Lou, Yuyi Tan, Jiang Du, Xijia Zhang, Ming Zhang 等 21 位作者
Intraoperative frozen-section diagnosis of central nervous system (CNS) lesions guides surgical decisions but is challenged by artefacts, diagnostic complexity and time constraints. Most pathology foundation models have limited exposure to CNS frozen tissue. Here we present FOCUS, a subspecialty foundation model pretrained on 27,930 frozen-section whole-slide images enriched for CNS tissue. FOCUS ranked first across all 11 diagnostic and 12 biomarker-prediction tasks in the internal test cohort, achieving mean AUCs of 0.969 and 0.877, respectively. This advantage was retained in the temporal and external test cohorts. We further organized a WHO-aligned diagnostic hierarchy, where FOCUS also outperformed comparator models. In a reader study, FOCUS assistance enabled junior readers to approach or exceed unassisted senior readers in hierarchical diagnostic accuracy and granularity. More importantly, FOCUS assistance enabled readers to correctly identify a mean of 63.0% of initially missed lymphoma cases (73.2% among junior readers), potentially avoiding unnecessary extensive resection. These findings highlight the potential of FOCUS to provide clinically actionable support for intraoperative CNS pathology and inform surgical decisions.
Zhenyu Liu, Yunxin Li Harbin Institute of Technology, Xuanyu Zhang, Qixun Teng, Shenyuan Jiang Dayu Algorithms Team, Xinyu Chen, Haoyuan Shi, Haolan Chen Tencent 等 15 位作者
Recent advances in unified multimodal models indicate a clear trend towards comprehensive content generation. However, the auditory domain remains a significant challenge, with music and speech often developed in isolation, hindering progress towards universal audio synthesis. This separation stems from inherent task conflicts between semantic speech and structural music modeling, and severe data imbalances, which impede the development of a truly unified model. To address these challenges, we propose UniMoE-Audio a unified speech and music generation model built upon a novel Dynamic-Capacity Mix-of-Experts (DCMoE) framework. Architecturally, UniMoE-Audio extends the conventional MoE paradigm by introducing a Top-P routing strategy for adaptive capacity allocation. To tackle data imbalance, we introduce a three-stage training curriculum: 1) Independent Specialist Training leverages original datasets to instill domain-specific knowledge into each specialists without interference; 2) MoE Integration and Warmup incorporates these specialists into the UniMoE-Audio architecture, warming up the gate module and shared expert using a subset of balanced dataset; and 3) Synergistic Joint Training trains the entire model end-to-end on the fully balanced dataset, fostering enhanced cross-domain synergy. Extensive experiments show that UniMoE-Audio not only achieves state-of-the-art performance on major speech and music generation benchmarks, but also demonstrates superior synergistic learning, mitigating the performance degradation typically seen in naive joint training. Our findings highlight the substantial potential of specialized MoE architecture and curated training strategies in advancing universal audio generation.
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cs.CL · cs.CV
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表