We introduce Nemotron 3.5 Super and Nemotron 3.5 Lightning, open and efficient Mixture-of-Experts Hybrid Mamba-Transformer models designed for reasoning, long-context understanding, and agentic workloads. Super is a 120B-parameter, 12B-active multimodal model, while Lightning is a smaller 30B-parameter, 3B-active text model; both designed for efficient deployment. Both models combine large-scale distillation, long-context training, and native speculative decoding, while Super further incorporates Indic continued pretraining and agentic software-engineering mid-training. We develop a comprehensive post-training pipeline spanning supervised fine-tuning and reinforcement learning (RLVR and RLHF), complemented in Super by specialized teacher training and multi- teacher on-policy distillation (MOPD). This transforms Super from a text-only base model into a multimodal agent capable of reasoning over text, images, video, and interactive tool environments. We further explore test-time scaling through parallel agent execution and self-verification. Across training and deployment, we jointly optimize capability and efficiency. Indic continued pretraining improves Indian-language benchmarks by up to 9.82 percentage points, while agentic mid-training strengthens software-engineering capabilities and robustness across agent harnesses. The post-trained Super model achieves 51.78% on SWE-bench Pro, surpassing Nemotron 3 Ultra despite using approximately 4.6x fewer active parameters. Post-training MTP boosting improves speculative- decoding acceptance length by up to 21.8% under probabilistic draft sampling, while NVFP4 quantization achieves 99.62% median accuracy recovery relative to BF16. Inference optimizations enable up to 4,856 output tokens/s/GPU on GB200 while sustaining at least 50 tokens/s/user.
Implicit neural representation (INR) methods for deformable medical image registration require the network parameters to be optimized for each new image pair, making adaptation speed a practical limitation. This work investigates whether early adaptation can be accelerated using an initialization learned from a collection of previously solved registration tasks. We examine two schemes: Reptile meta-initialization and STRAINER transfer of the shared component of a coordinate network. KAN-IDIR is used as the base INR displacement-field model. Experiments are conducted on OASIS-1, with 364 consecutive pairs used for training and 49 pairs for test-time adaptation. Registration quality is evaluated using mean Dice and HD95, together with the fraction of voxels with a negative Jacobian determinant at iteration 1500. In the configurations studied, both schemes yield higher Dice and lower HD95 at early iterations than random initialization. Reptile numerically outperforms STRAINER under a small iteration budget, although their pretraining budgets are not matched. As the number of iterations increases, the differences between the schemes shrink. STRAINER pretraining takes 39-40 minutes, compared with 44.98 hours for Reptile.
Egor Maximov, Aleksei Merkelov, Vasiliy Alekseev, Ivan Krivorotov, Valentin Beliaev, Nikita Arsenin, Dmitry Bocharov, Aleksei Goncharov
Hybrid language models keep a key-value (KV) cache only in their few full-attention layers, but this cache is still the part of a prompt's state that grows with the prompt and that must be stored or moved to reuse it. We present DCKV, a differentiable codec for the KV cache and the first KV-cache codec that is trained end to end. Its transform, its quantizer and its entropy models, which are conditioned on the prompt tokens and on already decoded neighbouring positions, are optimized together against the frozen language model, both for the code length that the entropy models assign and for the change of the model's output. On Qwen3.5-2B, DCKV stores a compressed token in more than 55 times fewer bytes than bf16 at a loss of at most 1.8 points on three long-context benchmarks, and in more than 100 times fewer bytes at a loss of at most 3.6 points.
Daria Frolova, Talgat Daulbaev, Egor Sevriugov, Sergei A. Nikolenko, Dmitry N. Ivankov, Ivan Oseledets, Marina A. Pak
Predicting a protein--ligand binding pose is central to structure-based drug design, yet current docking methods still struggle to combine speed, accuracy and physical plausibility. We introduce Matcha, which refines a ligand pose by three flow-matching stages in translation, rotation and torsion space, then minimizes, filters and ranks candidates with GNINA. Across the benchmarks considered, Matcha attains the strongest physical plausibility and runs about $28\times$ faster than modern large-scale co-folding models. Code and benchmarking artifacts are available at https://github.com/LigandPro/Matcha and archived at https://doi.org/10.5281/zenodo.23568093. Model checkpoints are archived at https://doi.org/10.5281/zenodo.23569055.
GHARP: Real-time Gaussian Head Animation from Large-scale Reconstruction Prior
Ali Benlalah, Sepehr Johari, Patricia Vitoria, Armin Kappeler, Artem Sevastopolsky, Alexander Jung, Gabriele Fanelli, Kevin Mader 等 17 位作者
AI 速览：GHARP 将头部动画解耦为离线身份建模与实时表情残差预测两阶段，并引入身体对齐网络缓解身体与衣物区域的不确定性，作者报告在 Ava-256 上达到先进质量且推理显著加速。
We present GHARP (Real-time Gaussian Head Animation from Large-scale Reconstruction Prior), a method that animates 3D human heads in real time from a few input images of a subject and a driving expression signal. We decouple the problem into an identity stage that builds a representation of the subject's geometry and appearance offline, and an animation stage that predicts expression-dependent residuals on top of it at runtime. This separation offers a favorable trade-off with respect to fidelity, quality and runtime: the identity stage can be expensive while the animation stage runs a lightweight network, optimized for mobile devices. Our method performs animation in a semantically structured latent space of a pretrained reconstruction model, where expression changes remain spatially contained, making residual prediction efficient. This reconstruction prior provides a consistent spatial layout, allowing fusion of multiple input views into a compact, fixed-size canonical Gaussian representation. While this two-stage design improves the runtime-quality trade-off, it still inherits a problem common to all expression-driven avatar methods: expression codes describe only the face and thus omit body pose and clothing position, making these regions underspecified in the input. The animation network faces an ill-posed mapping and resorts to averaging over conflicting body appearances, producing blur and temporal flicker. We address this with a body alignment network that learns to align the person's body in the target image with the input reference images, removing the ambiguity from the training signal. Our method achieves state-of-the-art quality on the Ava-256 benchmark while running up to 13x faster on an A100 GPU with 8x fewer Gaussians.