Predicting enzyme kinetic parameters quantifies how efficiently an enzyme catalyzes a specific substrate under defined biochemical conditions. Canonical parameters such as the turnover number (k_\text cat ), Michaelis constant (K_\text m ), and inhibition constant (K_\text i ) depend jointly on the enzyme sequence, the substrate chemistry, and the conformational adaptation of the active site during binding. Many learning pipelines simplify this process to a static compatibility problem between the enzyme and substrate, fusing their representations through shallow operations and regressing a single value. Such formulations overlook the staged nature of catalysis, which involves both substrate recognition and conformational adaptation. In this regard, we reformulate kinetic prediction as a staged multimodal conditional modeling problem and introduce the Enzyme-Reaction Bridging Adapter (ERBA), which injects cross-modal information via fine-tuning into Protein Language Models (PLMs) while preserving their biochemical priors. ERBA performs conditioning in two stages: Molecular Recognition Cross-Attention (MRCA) first injects substrate information into the enzyme representation to capture specificity; Geometry-aware Mixture-of-Experts (G-MoE) then integrates active-site structure and routes samples to pocket-specialized experts to reflect induced fit. To maintain semantic fidelity, Enzyme-Substrate Distribution Alignment (ESDA) enforces distributional consistency within the PLM manifold in a reproducing kernel Hilbert space. Experiments across three kinetic endpoints and multiple PLM backbones, ERBA delivers consistent gains and stronger out-of-distribution performance compared with sequence-only and shallow-fusion baselines, offering a biologically grounded route to scalable kinetic prediction and a foundation for adding cofactors, mutations, and time-resolved structural cues.
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cs.CV · cs.CL
Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2026 · 正式发表
Humanoid robots have achieved significant progress in motion generation and control, exhibiting movements that appear increasingly natural and human-like. Inspired by the Turing Test, we propose the Motion Turing Test, a framework that evaluates whether human observers can discriminate between humanoid robot and human poses using only kinematic information. To facilitate this evaluation, we present the Human-Humanoid Motion (HHMotion) dataset, which consists of 1,000 motion sequences spanning 15 action categories, performed by 11 humanoid models and 10 human subjects. All motion sequences are converted into SMPL-X representations to eliminate the influence of visual appearance. We recruited 30 annotators to rate the human-likeness of each pose on a 0-5 scale, resulting in over 500 hours of annotation. Analysis of the collected data reveals that humanoid motions still exhibit noticeable deviations from human movements, particularly in dynamic actions such as jumping, boxing, and running. Building on HHMotion, we formulate a human-likeness evaluation task that aims to automatically predict human-likeness scores from motion data. Despite recent progress in multimodal large language models, we find that they remain inadequate for assessing motion human-likeness. To address this, we propose a simple baseline model and demonstrate that it outperforms several contemporary LLM-based methods. The dataset, code, and benchmark release publicly at http://www.lidarhumanmotion.net/mtt/
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cs.CV · cs.CL
Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2026 · 正式发表
Recent studies have made notable progress in video representation learning by transferring image-pretrained models to video tasks, typically with complex temporal modules and video fine-tuning. However, fine-tuning heavy modules may compromise inter-video semantic separability, i.e., the essential ability to distinguish objects across videos. While reducing the tunable parameters hinders their intra-video temporal consistency, which is required for stable representations of the same object within a video. This dilemma indicates a potential trade-off between the intra-video temporal consistency and inter-video semantic separability during image-to-video transfer. To this end, we propose the Consistency-Separability Trade-off Transfer Learning (Co-Settle) framework, which applies a lightweight projection layer on top of the frozen image-pretrained encoder to adjust representation space with a temporal cycle consistency objective and a semantic separability constraint. We further provide a theoretical support showing that the optimized projection yields a better trade-off between the two properties under appropriate conditions. Experiments on eight image-pretrained models demonstrate consistent improvements across multiple levels of video tasks with only five epochs of self-supervised training. The code is available at https://github.com/yafeng19/Co-Settle.
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cs.CV
Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2026 · 正式发表
Whole-Slide Images (WSIs) are widely used for estimating the prognosis of cancer patients. Current studies generally follow a cancer-specific learning paradigm. However, the available training samples for one cancer type are usually scarce in pathology. Consequently, the model often struggles to learn generalizable knowledge, thus performing worse on the tumor samples with inherent high heterogeneity. Although multi-cancer joint learning and knowledge transfer approaches have been explored recently to address it, they either rely on large-scale joint training or extensive inference across multiple models, posing new challenges in computational efficiency. To this end, this paper proposes a new scheme, Sparse Task Vector Mixup with Hypernetworks (STEPH). Unlike previous ones, it efficiently absorbs generalizable knowledge from other cancers for the target via model merging: i) applying task vector mixup to each source-target pair and then ii) sparsely aggregating task vector mixtures to obtain an improved target model, driven by hypernetworks. Extensive experiments on 13 cancer datasets show that STEPH improves over cancer-specific learning and an existing knowledge transfer baseline by 5.14% and 2.01%, respectively. Moreover, it is a more efficient solution for learning prognostic knowledge from other cancers, without requiring large-scale joint training or extensive multi-model inference.
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cs.CV
Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2026 · 正式发表