As pretraining scales, medical language models have advanced rapidly in clinical question answering. Their ability to achieve effective physiological control through sustained intervention still lacks systematic quantitative evaluation. Type 1 diabetes provides a concrete setting: impaired insulin secretion creates dependence on exogenous insulin, with dosing continually adjusted using information about meals, exercise, illness, and glucose measurements. We introduce DiabAgent, a research suite for agentic physiological control comprising the Agentic Physiological Control (APC) framework, the DiabetSim simulator, and the SweetBench benchmark. APC controls glucose through medical-device tools, using ongoing observations to infer individual states, accumulate personal experience, and choose treatment actions. We build DiabetSim to simulate different patients, events, and device conditions for scalable virtual testing and training. Using DiabetSim, we construct SweetBench by instantiating 32 scenario designs as 212 glucose-control tasks. With Claude Opus 5.5 and a fixed decision interval of one hour, APC achieves a COGI of 73.5, compared with 71.2 for the open-source closed-loop baseline OpenAPS. Ablations further show that individual adaptation and contextual information improve glucose control. Combining high-frequency rule-based control with lower-frequency agent decisions shows potential for balancing control performance and computational cost. Our work provides a framework, simulator, and evaluation foundation for agents to participate in human physiological control.
Xinjie Chen, Minpeng Liao, Guoxin Chen, Chengxi Li Alibaba Group, Biao Fu, Kai Fan Alibaba Group, Xinggao Liu
Reinforcement learning with verifiable rewards (RLVR) has recently advanced the reasoning capabilities of large language models (LLMs). We investigate RLVR from a sample-centric perspective and introduce LPPO (Learning-Progress and Prefix-guided Optimization), a framework of progressive optimization techniques. Our work addresses a critical question: how to best leverage a small set of trusted, high-quality demonstrations, rather than simply scaling up data volume. First, motivated by how hints aid human problem-solving, we propose prefix-guided sampling, an online data augmentation method that incorporates partial solution prefixes from expert demonstrations to guide the policy, particularly for challenging instances. Second, inspired by how humans focus on important questions aligned with their current capabilities, we introduce learning-progress weighting, a dynamic strategy that adjusts each training sample’s influence based on model progression. We estimate sample-level learning progress via an exponential moving average of per-sample pass rates, promoting samples that foster learning and de-emphasizing stagnant ones. Experiments on mathematical-reasoning benchmarks demonstrate that our methods outperform strong baselines, yielding faster convergence and a higher performance ceiling, with these gains proving robust across diverse model architectures, scales, and reinforcement learning optimizers.
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Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表