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Despite impressive progress, existing feed-forward large 3D reconstruction models produce a single, irrevocable prediction. When these models fail, there is no mechanism to correct their mistakes. To address this limitation, we introduce Click3R, a framework for interactive geometric correction of feed-forward models using sparse human correspondence clicks. Given an image pair and a small set of cross-view point correspondences provided by a user, Click3R injects geometric constraints into the 3D reconstruction networks through a lightweight point correspondence adapter, enabling the model to resolve ambiguities in challenging scenarios such as repetitive textures, symmetric structures, large viewpoint changes, or textureless regions. To evaluate interactive reconstruction, we curate a challenging benchmark specifically designed to expose failure modes of existing feed-forward 3D reconstruction methods. Experiments show that Click3R reduces reconstruction error with as few as a single correspondence click, improving performance on both standard and our curated benchmarks. Our results highlight that sparse human interaction provides an effective and practical mechanism for correcting geometric reconstruction errors.

Vision-language models (VLMs) exhibit strong zero-shot generalization but remain vulnerable to adversarial attacks. Existing adversarial fine-tuning methods often use pre-trained model guidance to preserve image--text alignment while improving robustness. Our analysis of visual representation drift reveals complementary limitations of two representative forms of guidance. Matching visual features constrains all directions equally, providing broad coverage without semantic emphasis. Matching prediction distributions prioritizes semantically relevant directions, but remains limited by the candidate texts and prediction probabilities. These limitations can hinder preservation of pre-trained image--text relationships and degrade zero-shot performance. We therefore propose Textual Response-Aware Guidance (TRAG), which constrains visual representation drift using the pre-trained text encoder's responses to local variations in input embeddings. TRAG constructs anchor-level constraints from the response directions and magnitudes around semantic anchors, then aggregates them using pre-trained image--anchor relevance, yielding an image-adaptive constraint. Extensive experiments across architectures and tasks demonstrate state-of-the-art clean and robust performance. Further analysis shows that TRAG helps preserve pre-trained image--text relationships.

Toxicity remains a leading cause of early-stage drug development failure. Despite advances in molecular design and property prediction, the task of molecular toxicity repair, generating structurally valid molecular alternatives with reduced toxicity, has not yet been systematically defined or benchmarked. To fill this gap, we introduce ToxiMol, the first benchmark task for general-purpose Multimodal Large Language Models (MLLMs) focused on molecular toxicity repair. We construct a standardized dataset covering 11 primary tasks and 660 representative toxic molecules spanning diverse mechanisms and granularities. We design a prompt annotation pipeline with mechanism-aware and task-adaptive capabilities, informed by expert toxicological knowledge. In parallel, we propose an automated evaluation framework, ToxiEval, which integrates toxicity endpoint prediction, synthetic accessibility, drug-likeness, and structural similarity into a high-throughput evaluation chain for repair success. We systematically assess 43 mainstream general-purpose MLLMs and conduct multiple ablation studies to analyze key issues, including evaluation metrics, candidate diversity, and failure attribution. Experimental results show that although current MLLMs still face significant challenges on this task, they begin to demonstrate promising capabilities in toxicity understanding, semantic constraint adherence, and structure-aware editing.