TuMAP：一种双视角、形态型感知的病理组学流程，用于量化肾小管重塑
TuMAP: A Dual-View, Morphotype-Aware Pathomics Pipeline for Quantifying Renal Tubular Remodeling
Ruijie Wu, Yuechen Yang, Yanfan Zhu, Yu Wang, Shilin Zhao, Ming-Tsun Tsai, Szu-Yuan Li, Shuo-Ming Ou 等 11 位作者
AI 速读 基于摘要
作者提出 TuMAP 流程，结合双视角基础模型表征、形态型标注与患者级统计推断，从 PAS 染色肾活检切片中量化肾小管形态型组成及形态型内差异。
cs.CV · eess.IV
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Quantifying disease-associated renal tubular remodeling is challenging because tubular appearances are heterogeneous. We introduce TuMAP (Tubular Morphotype-Aware Pathomics), a pipeline combining (1) dual-view foundation-model representations and provisional morphotype annotation, (2) compositional and within-morphotype pathomics, and (3) patient-level statistical inference. From 456,158 tubules in 358 PAS-stained kidney biopsy slides, TuMAP identified eight image-based morphotypes, seven of which showed stable subsampling assignments. Across 219 patients in six diagnostic groups, diabetic nephropathy (DN) and tubulointerstitial nephritis/acute tubular injury (TIN/ATI) each differed from minimal change disease in seven morphotype proportions, while IgA nephropathy differed in six. DN showed reduced nuclear solidity and increased eccentricity across all eight morphotypes. Area-normalized nuclear density exposed additional within-morphotype differences. TuMAP provides a framework for separating changes in tubular morphotype composition from phenotypic differences within morphotypes.