Yuhao Wang, Zelin Zang, Yuxuan Liu, Zhen Lei, Stan Z. Li
Single-cell transcriptomes are sparse, unordered measurements of coordinated biological activity, yet many self-supervised models define their learning target at the level of individual genes or reconstructed expression values. Here we introduce GB-JEPA, a joint-embedding predictive architecture in which graph-connected gene blocks form the latent prediction units. A student encoder observes the genes outside each target block, whereas an exponential-moving-average teacher represents the full observed gene set. Teacher states are aggregated within a block before the prediction error is evaluated, converting thousands of sparse gene-level targets into a small collection of intermediate-scale latent targets. The graph therefore serves not only as prior information, but also as a mechanism for controlling the structure, scale and predictability of self-supervision. We evaluate the resulting frozen cell representations through objective diagnostics, cell-state annotation, continuous-expression and pathway probes, perturbation-response prediction, computational measurements and direct biological interrogation. This study presents a graph-structured route for adapting JEPA learning to molecular observations and a general framework for designing prediction units from relationships native to a biological modality.
Luozheng Qin, Yuhan Zhu, Changhai Zhou, Qian Qiao, Jun Gao, Yuhua Zhou, Harry Zhang, Xiangyu Zeng 等 13 位作者
Spatial intelligence lets an agent perceive and act in the physical world, and many of its judgments must be made at interaction rates: which spatial relation holds, how far an object is, or where to place it. Vision-language models (VLMs) produce these answers by free-form text generation, paying for autoregressive decoding and answer parsing even though the output space is compact: one of a few options, a scalar, or a 2D point. In light of this, we introduce MJev-Spatial, a System 1 multimodal decision model that tackles all three types of spatial understanding tasks within a unified classification framework. Specifically, MJev-Spatial treats each candidate as a class and scores it using the backbone's pretrained query and key projections, without adding parameters. The candidates are the given options for choice tasks, or value bins and image regions refined through coarse-to-fine classification for numerical and point prediction, respectively. At inference, each classification decision takes a single forward pass and generates no answer tokens. To train on heterogeneous spatial data efficiently, we supervise all coarse-to-fine stages jointly with teacher forcing in one forward pass, and combine this with length-aware global batching and cross-GPU load balancing, raising training throughput by 30.8% over the original batching strategy. Built on Qwen3.5-4B and trained on 12.3M question-answer pairs converted from existing spatial datasets, MJev-Spatial achieves the highest overall score (65.64%) among eight tested models, ranks first on seven of twelve benchmarks, and outperforms its unmodified autoregressive base model on all twelve, while running 2.5 times faster than the fastest autoregressive baseline and 5.6 times faster than the base model.
Binghai Wang, Yantao Liu Qwen Team, Alibaba Group, Yuxuan Liu Qwen Team, Alibaba Group, Tianyi Tang Alibaba Group, Shenzhi Wang Alibaba Group, Chang Gao Alibaba Group, Chujie Zheng Alibaba Group, Yichang Zhang Alibaba Group 等 16 位作者
Generative Reward Models (GenRMs) and LLM-as-a-Judge exhibit deceptive alignment by producing correct judgments for incorrect reasons, as they are trained and evaluated to prioritize Outcome Accuracy, which undermines their ability to generalize during RLHF. We introduce Rationale Consistency, a fine-grained metric that quantifies the alignment between the model’s reasoning process and human judgment. Our evaluation of frontier models reveals that rationale consistency effectively discriminates among state-of-the-art models and detects deceptive alignment, while outcome accuracy falls short in both respects. To mitigate this gap, we introduce a hybrid signal that combines rationale consistency with outcome accuracy for GenRM training. Our training method achieves state-of-the-art performance on RM-Bench (87.1%) and JudgeBench (82%), surpassing outcome-only baselines by an average of 5%. Using RM during RLHF, our method effectively improves performance as demonstrated on Arena Hard v2, notably yielding a 7% improvement in creative writing tasks. Further analysis confirms that our method escapes the deceptive alignment trap, effectively reversing the decline in rationale consistency observed in outcome-only training.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表