arXiv:2602.13930 · v2
MamaDino: A Hybrid Vision Model for Breast Cancer 3-Year Risk Prediction
摘要
Breast cancer screening programmes increasingly seek to move from one-size-fits-all intervals to risk-adapted and personalized strategies. Deep learning (DL) has enabled image-based risk models with stronger 1- to 5-year prediction than clinical models, but leading systems (e.g., Mirai) typically use convolutional backbones, high-resolution inputs (>1M pixels) and simple multi-view fusion, with limited explicit modelling of contralateral asymmetry. We hypothesised that combining complementary inductive biases (convolutional and transformer-based) with explicit contralateral asymmetry modelling would allow us to match state-of-the-art 3-year risk prediction performance on lower-resolution mammograms, suggesting that using less detail in a more structured way can recover state-of-the-art accuracy. We present MamaDino, a mammography-aware multi-view attentional DINO model. MamaDino fuses frozen self-supervised DINOv3 ViT-S features with a trainable CNN encoder at 512x512 resolution and aggregates bilateral breast information via a BilateralMixer to output a 3-year breast cancer risk score. We train on 53,883 women from OPTIMAM (UK) and evaluate on matched 3-year case-control cohorts: an in-distribution test set from four screening sites and an external out-of-distribution cohort from an unseen site. At breast level, MamaDino achieves discrimination comparable to Mirai on internal and external tests while using ~13x fewer input pixels. Adding the BilateralMixer improves patient-level discrimination to AUC 0.736 (vs Mirai 0.713) in-distribution and 0.677 (vs Mirai 0.676) out-of-distribution, with overlapping confidence intervals. Performance was evaluated across age, ethnicity, scanner manufacturer, tumour type and grade. These findings suggest that complementary inductive biases and explicit contralateral modelling can achieve Mirai-comparable discrimination at lower resolution.
作者备注：20 pages, 3 figures. Extended version of the peer-reviewed MICCAI 2026 conference paper, including additional architectural details, cohort characteristics, subgroup evaluations, and tumour-specific analyses
期刊信息：Medical Image Computing and Computer Assisted Intervention (MICCAI 2026), Lecture Notes in Computer Science, vol. 16887, pp. 418-427, Springer, 2026