← 研踪 PaperTrailarXiv:2609.07655 · v3
Online Surrogate Repair: Decoupling High-Fidelity Feedback from Search Length in Closed-Loop Discovery
首次提交 2026-09-07 23:42
版本更新 2026-10-29 21:58
雷达观测 2026-10-30 13:28
摘要
Closed-loop AI scientists can generate candidate designs at low marginal computational cost, whereas reliable feedback may require wet-lab synthesis, characterization, or high-fidelity computation. Addressing this imbalance through custom laboratory automation remains infrastructure-intensive and costly, while replacing new experiments with a fixed surrogate leaves persistent model errors that can be amplified by optimization. We propose \emph{online surrogate repair} (OSR), a closed-loop algorithm that uses sparse high-fidelity evaluations to update the surrogate throughout a longer agent search conducted primarily with inexpensive surrogate feedback. An acquisition rule selects which designs from the agent's accumulated proposals receive high-fidelity evaluation, and the resulting labels update the surrogate used in subsequent episodes. Across controlled synthetic environments, we demonstrate that improving global surrogate fit does not necessarily reduce maximum regret, whereas Q90-UCB and expected improvement (EI) substantially reduce regret by directing evaluations toward regions that determine the optimizer's decisions. \osradded{Across LLM and Chemeleon workflows, Online EI reduces the amount of oracle queries required by 84.3--90.3\% for matching discovery counts and by 77.9--81.6\% for matching the quality of the best material found.} Online surrogate repair introduces a third feedback regime between fixed-surrogate operation and high-fidelity feedback after every episode, separating the frequency of high-fidelity evaluation from the duration of the agent's search.
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v3 · 2026-10-29 21:58 · 最新观测版本
Online Surrogate Repair: Decoupling High-Fidelity Feedback from Search Length in Closed-Loop Discovery
Closed-loop AI scientists can generate candidate designs at low marginal computational cost, whereas reliable feedback may require wet-lab synthesis, characterization, or high-fidelity computation. Addressing this imbalance through custom laboratory automation remains infrastructure-intensive and costly, while replacing new experiments with a fixed surrogate leaves persistent model errors that can be amplified by optimization. We propose \emph{online surrogate repair} (OSR), a closed-loop algorithm that uses sparse high-fidelity evaluations to update the surrogate throughout a longer agent search conducted primarily with inexpensive surrogate feedback. An acquisition rule selects which designs from the agent's accumulated proposals receive high-fidelity evaluation, and the resulting labels update the surrogate used in subsequent episodes. Across controlled synthetic environments, we demonstrate that improving global surrogate fit does not necessarily reduce maximum regret, whereas Q90-UCB and expected improvement (EI) substantially reduce regret by directing evaluations toward regions that determine the optimizer's decisions. \osradded{Across LLM and Chemeleon workflows, Online EI reduces the amount of oracle queries required by 84.3--90.3\% for matching discovery counts and by 77.9--81.6\% for matching the quality of the best material found.} Online surrogate repair introduces a third feedback regime between fixed-surrogate operation and high-fidelity feedback after every episode, separating the frequency of high-fidelity evaluation from the duration of the agent's search.
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