← 研踪 PaperTrailarXiv:2611.09746 · v1
Continuous wavelet-based feature extraction for laser-induced breakdown spectroscopy classification of human plasma samples
首次提交 2026-11-07 01:17
版本更新 2026-11-07 01:17
雷达观测 2026-11-09 13:22
摘要
Extracting discriminative features from laser-induced breakdown spectroscopy (LIBS) spectra is important for the classification of complex biological samples. This study evaluates continuous wavelet transform (CWT)-based spectral peak extraction for distinguishing human plasma samples labeled as SARS-CoV-2-positive or negative. Plasma specimens from 181 individuals, comprising 53 positive samples and 128 negative controls, were deposited as 5 μL droplets on silicon substrates and dried before analysis. Spectra were acquired using a nanosecond Nd:YAG laser operating at 1064 nm, with 100 single-shot measurements collected per specimen and averaged after intensity-based outlier rejection. CWT-based peak detection was coupled with a support vector machine (SVM) classifier. The reported leave-one-out evaluation yielded an accuracy of 93.00%, sensitivity of 94.67%, and specificity of 91.61%; these estimates remain provisional pending reconciliation with specimen-level predictions. Features identified by the CWT pipeline included emission lines assigned to Ca II, K I, and N I. The workflow provides a basis for examining spectral features associated with the studied plasma groups. Independent validation and assessment of specimen, substrate, and acquisition-related variability are required to establish generalizability and diagnostic relevance.
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v1 · 2026-11-07 01:17 · 最新观测版本
Continuous wavelet-based feature extraction for laser-induced breakdown spectroscopy classification of human plasma samples
Extracting discriminative features from laser-induced breakdown spectroscopy (LIBS) spectra is important for the classification of complex biological samples. This study evaluates continuous wavelet transform (CWT)-based spectral peak extraction for distinguishing human plasma samples labeled as SARS-CoV-2-positive or negative. Plasma specimens from 181 individuals, comprising 53 positive samples and 128 negative controls, were deposited as 5 μL droplets on silicon substrates and dried before analysis. Spectra were acquired using a nanosecond Nd:YAG laser operating at 1064 nm, with 100 single-shot measurements collected per specimen and averaged after intensity-based outlier rejection. CWT-based peak detection was coupled with a support vector machine (SVM) classifier. The reported leave-one-out evaluation yielded an accuracy of 93.00%, sensitivity of 94.67%, and specificity of 91.61%; these estimates remain provisional pending reconciliation with specimen-level predictions. Features identified by the CWT pipeline included emission lines assigned to Ca II, K I, and N I. The workflow provides a basis for examining spectral features associated with the studied plasma groups. Independent validation and assessment of specimen, substrate, and acquisition-related variability are required to establish generalizability and diagnostic relevance.
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