This paper presents GSCV++, a lightweight pipeline for 3D {G}aussian {S}platting (GS) sequences {C}ompression with standard {V}ideo codecs. To meet the requirements of low-complexity and hardware compatibility from the industry, GSCV++ jointly improves preprocessing, 3D-to-2D mapping, and practical video compression configuration of GS compression. First, for preprocessing, energy-adaptive inter-frame spherical harmonic (SH) alternative current (AC) dimensionality reduction (EA-SHDR) is proposed to produces a compact and stable temporal SH AC feature space. It can reduce the data volume of following mapping and practical compression, as well as less complexity while eliminating redundant information. Second, for 3D-to-2D mapping, prior-based Inter-MiniPLAS (P-MiniPLAS) is designed to generate smooth 2D feature maps through prior-based weighting factor inference and small scale remapping. Compared with vanilla Parallel Linear Assignment Sorting (PLAS) and Morton scan, P-MiniPLAS ensures the generated 2D maps are more suitable for the video codec while maintaining a low level of computational complexity. Third, for practical compression, content-aware generalized compression (CA-GC) is developed to use a non-uniform bit-depth split for coordinate map generation, and a coding unit size selection is introduced for efficient compression complexity control, which fully exploits the performance of video codecs without involving normative changes. Experiments demonstrate that GSCV++ reports over 20\% in intra- and 60\% in inter-prediction rate-distortion gains compared with state-of-the-art (SOTA) methods. GSCV++ also achieves faster 2D map generation, encoding, and decoding than other SOTA methods using the same type of video codecs. Ablation studies verify the effectiveness and robustness of the proposed modules and provide insights for subsequent research.
Scientific discovery is driven by scientists generating novel hypotheses for complex problems that undergo rigorous experimental validation. To augment this process, we introduce Co-Scientist, a multi-agent AI system built on Gemini for structured scientific thinking and hypothesis generation. Co-Scientist aims to help scientists discover new original knowledge. Conditioned on their research objectives and prior scientific evidence, it formulates demonstrably novel research hypotheses for experimental verification. The system's design involves agents continuously generating, critiquing and refining hypotheses accelerated by scaling test-time compute. Key contributions include: (1) a multi-agent architecture with an asynchronous task execution framework for flexible compute scaling; (2) a tournament evolution process for self-improving hypotheses generation. Automated evaluations show continued benefits of test-time compute scaling, improving hypothesis quality over time. While general purpose, we focus the validation in three biomedical applications: drug repurposing, novel target discovery, and explaining mechanisms of anti-microbial resistance. Specifically, Co-Scientist helped identify new drug repurposing candidates and synergistic combination therapies for acute myeloid leukemia, which were validated through in vitro experiments. These real-world validations demonstrate the potential of Co-Scientist to accelerate scientific discovery and usher in an era of AI empowered scientists.