Planetary Geospatial Foundation Models: A New Paradigm for Global Public Health
Arbaaz Muslim, Aviv Slobodkin, Katherine Wheeler-Martin, Eric Zhou, John Brittain, Martin Frasch, Hamsa Subramaniam, Jacob Bien 等 38 位作者
AI 速览：提出并展示地理空间基础模型 PDFM 如何以可泛化的地点表征补充传统流行病学工作流，并在多国多任务案例中改善公共卫生监测。
The efficacy of traditional disease prediction is limited by spatial gaps and temporal lags, which impact the timing and targets of resource deployments. Outbreaks escalate undetected, chronic disease burdens are quantified years later, and at-risk populations in data-sparse regions remain unaddressed. Planetary geospatial foundation models complement existing epidemiological workflows to provide operational improvements, encoding multimodal search, mobility, and environmental signals into generalizable place representations. As illustrations of this complementarity, we present independent global health case studies of Google Earth AI's Population Dynamics Foundation Model (PDFM) -- a foundation model for geospatial inference -- across four domains (vaccine-preventable, communicable, noncommunicable, maternal mental health), five tasks (spatial extrapolation, interpolation/nowcasting, probabilistic forecasting, prospective forecasting, risk stratification), and four countries (USA, Canada, Mexico, and the Democratic Republic of the Congo). Across these case studies, PDFM addresses critical surveillance gaps across domains: improving US-Canada border MMR vaccination coverage predictions by capturing cross-border behavioral spillovers domestic models miss; nowcasting cardiovascular disease to accelerate data availability; enhancing short-term municipal Mexican dengue forecasts for timely outbreak vector control; improving forecasts of cholera hotspots; and adding a transferable signal to individual-level postpartum-depression risk prediction in US states the model had never seen, while not replacing individual socioeconomic data or closing demographic screening gaps. Together, these results showcase capabilities of geospatial foundation models for public health surveillance.
Sarah Martinson, Michael P. Brenner, Martyna Plomecka, Brian P. Williams, Nicholas G. Reich, Zahra Shamsi
Probabilistic forecasting of infectious diseases is crucial for public health monitoring and preparedness but has historically relied on labor-intensive manual model curation by expert modeling teams. Bespoke development is an obstacle to scaling models to granular geographic resolutions or emerging pathogens. Here, we prospectively evaluate Empirical Research Assistance (ERA), an autonomous system that uses Large Language Model-guided tree search to iteratively generate, evaluate, and optimize executable forecasting software. ERA was primarily prompted with methodological approaches to implement, while in some instances it was tasked with developing forecasting approaches from scratch. In a fully prospective, real-time evaluation during the 2025-26 United States respiratory season, ERA generated methodologically diverse models for influenza, COVID-19, and respiratory syncytial virus (RSV). Aggregating a selection of these automatically-generated models yielded an ensemble that ranked first overall in official Centers for Disease Control and Prevention (CDC) post-season evaluations and outperformed the gold-standard CDC forecast ensembles across all three pathogens in a real-time prediction challenge. Additionally, ERA successfully navigated data-scarce scenarios for RSV. Controlled retrospective ablations allowed for additional explorations of the impact of optimization target and instruction-following on forecast accuracy. Preliminary experiments indicate that ERA's search optimization metric influences behavior of output forecasts, and using higher-tier language models in-search improves predictive performance. By autonomously generating interpretable code that creates epidemiologically relevant predictions, this framework provides a path toward rapidly scaling high-quality disease forecasting.
Google Earth AI Geospatial Reasoning Agent: Capabilities and a Systematic Evaluation
Noam Slonim, Aviv Slobodkin, Gil Fidel, Gal Moshitch, Mimi Sun, Lily Mihalkova, Joydeep Paul, Per Bjornsson 等 37 位作者
AI 速览：介绍由 Gemini 驱动的 Google Earth AI 地理空间推理智能体 GRA，并发布两个基准，系统评估其工具与智能体编排的贡献。
Google Earth AI is a family of geospatial AI models, together with an agent that orchestrates them. We present this agent, Google Earth AI's Geospatial Reasoning agent (GRA), a Gemini-powered research system that combines geospatial data sources, foundation models, and tools to answer questions about our planet. GRA organizes these into modular domain skills and pairs them with upfront geospatial planning to decompose complex queries into multi-stage workflows. Evaluating such systems is hard: real-world problems admit multiple valid workflows, require data discovery across large catalogs, and rely on evolving ground truth. We introduce two benchmarks and release their development splits. GeoExpertQueries poses complex analytical problems grounded in practitioner use cases and refined by geospatial experts; each is paired with a consensus golden workflow from three independent experts and scored by a human-validated, tool-agnostic autorater. GeoKTools consists of templated queries with deterministic reference solvers that systematically vary the number of required tool types. We also use two external benchmarks, CBGB and UnivEARTH; the latter we find to be saturated. To isolate the contribution of GRA's tools and its agentic orchestration, we compare four configurations, each with Gemini 3.1 Pro and 3.8 Flash: a standalone LLM, the LLM with basic tools, the LLM with GRA's skills and tools but without its upfront planning and execution guidance, and GRA itself. With at most basic tools, an advanced model recovers much of the answer on templated queries but satisfies only a small fraction of the expert workflows on open-ended problems; GRA performs well on both. The largest step comes from GRA's skills and tools; on open-ended problems, its planning and execution guidance add a further gain with Gemini 3.8 Flash, letting Flash match or exceed Pro at lower cost.
AI 速览：作者构建了基于NASA地球观测文章与Google Earth Engine的编码基准UnivEARTH，发现零样本LLM智能体在地球观测问答上准确率仅40.0%，使用Reflexion后提升至约60%，但仍仅略高于随机水平。
Earth Observation (EO) provides critical planetary data for environmental monitoring, disaster management, climate science, and other scientific domains. In this work we ask: Are AI systems ready for reliable Earth Observation? To answer this, we introduce UnivEARTH, a coding benchmark of 408 yes/no questions from NASA Earth Observatory articles across 7 various topics and over 15 satellite instruments and sources. Using Google Earth Engine API as a tool in a zero-shot setup, LLM agents achieve an accuracy of 40.0% where the code fails to run over 44% of the time. To better understand LLM agent behavior, we also analyze the impact of using the JavaScript API versus Python and the effect of providing documentation. Furthermore, we find that using a Reflexion framework significantly reduces errors: Claude-4.5-Sonnet, Gemini-2.5-Pro, and GPT-5 accuracies rise to around 60%. However, these results remain only marginally above random chance. Taken together, our findings identify significant challenges to be solved before AI agents can automate earth observation, and suggest paths forward.
AI 速览：提出基于可信执行环境（TEE）的下一代联邦学习系统，首次提供可外部验证的中心化差分隐私（DP）保证，并改善隐私-效用权衡。
Federated Learning (FL) allows devices with private data to collaborate in training a shared model. We present a next-generation FL system based on Trusted Execution Environments (TEEs) that addresses operational challenges associated with earlier systems and provides externally verifiable central Differential Privacy (DP) guarantees for the first time while offering a better privacy-utility tradeoff. In our system, devices upload data encrypted with keys managed by a TEE-hosted Key Management Service (KMS). The uploaded data is cryptographically tied to a policy limiting the set of Python programs that may later process the data in server-side TEEs. External parties may inspect public transparency logs to observe the set of workloads allowed by these policies. Our experimental results show that the new system improves device coverage and favorably shifts privacy-utility curves by enabling collected data to be integrated into the server-side workload at a schedule that optimizes DP guarantees and is unaffected by device availability. Our new system has been productionized, enabling models for the Android Keyboard (Gboard) to be trained faster and achieve better accuracy under smaller, now externally verifiable privacy budgets in comparison to models trained using the prior system.
As people turn to LLMs for social advice, understanding their behavior in such contexts becomes essential. In this work, we focus on behavioral dispositions: the underlying tendencies that shape responses in social contexts. We introduce STAR, a framework for studying how closely the dispositions expressed by LLMs align with those of humans. STAR builds on established psychological questionnaires, adapting their items into realistic advice-seeking scenarios, as self-report may not transfer to actual advisory behavior. Using STAR, we construct a dataset of 23k scenarios, each validated by 3 raters and annotated with preferences from 10 participants. Across 25 LLMs, we find that (1) when human consensus is high, frontier models can fail to reflect it in 15-20% of cases, and smaller models fail at substantially higher rates; (2) when humans disagree, LLM recommendations are substantially less diverse than human choices, both within individual models and even across models from different providers, potentially narrowing the range of options users are guided toward; (3) LLMs' self-reported values are poor predictors of their recommendations. To support future research we make our dataset and code publicly available.
AI 速览：提出自主AI系统PPE，从自然语言查询出发自动完成多模态地理空间数据检索、融合与模型搜索，并在多个健康、风险与流行病预测任务上报告优于专家基线。
Addressing critical global challenges, from food security and disaster risk to disease outbreaks and socio-economic vulnerability, demands high-fidelity geospatial modeling. However, building predictive planetary models remains bottlenecked by a fragmented data ecosystem, requiring manual data retrieval, multimodal data curation and fusion along with iterative model selection. We present the Planetary Prediction Engine (PPE), an autonomous AI system that executes this end-to-end workflow directly from natural-language queries. PPE synthesizes multimodal datasets on the fly, retrieving spatiotemporally relevant covariates across open-web and Earth observation platforms (Data Commons, Google Earth Engine) and fusing them with geospatial foundation model embeddings (PDFM, AlphaEarth). Simultaneously, it searches over task-tailored model architecture families with automated overfitting guards. Across diverse tasks, geographies, and scientific domains, PPE consistently outperforms state-of-the-art or manually tuned expert baselines. For US spatial regression, PPE improves mean $R^2$ across 21 CDC health indicators (76.8% vs. 60.0%), FEMA national risk indices (64.9% vs. 60.0%), and the Social Vulnerability Index (66.2% vs. 58.6%). For spatial downscaling in data-scarce settings, PPE integrates localized proxies to double baseline accuracy in Nigerian food security indicators ($R^2$ of 66.1% vs. 31.5%). For epidemiological nowcasting of the 2026 DRC Bundibugyo Ebola outbreak, PPE achieves a Recall@10 of 83.3% (identifying 15 of 18 newly invaded health zones across five weekly forecasts), a +10.3 percentage-point improvement over the public state-of-the-art modeling (~73%). By combining autonomous multimodal planetary data discovery with targeted model optimization, PPE lowers the technical barrier to planetary-scale analytics, enabling rapid, customized, expert-level deployment.
AI 速览：提出“learning interactives”框架，借助Gemini的生成式UI能力自动构建定制化互动模拟，并通过教育者初步研究与专家教师的教学评分进行评估。
It is well established that students learn best through active engagement, particularly via interactive experiences tied to real-world concepts. Creating such experiences, however, typically requires labor-intensive design, costly development, and continuous teacher guidance to achieve measurably effective outcomes. Recent advances in generative UI open the door for a future of practice where the creation of tailored interactive experiences is automated. However, off-the-shelf models lack optimization for pedagogical precision and learning principles, often yielding unsatisfactory results for complex pedagogical constructs. To address these limitations, we present learning interactives, a structured framework leveraging the generative UI capabilities of Gemini to construct effective customized interactive simulations. We evaluate our approach through both an initial study with educators as well as a pedagogical rating of a varied set of simulations by expert teachers.
GlucoFM: A Dual-Stream Foundation Model for Continuous Glucose Monitoring
Zechen Li, Keerthana Natarajan, Weizhi Zhang, Menglian Zhou, Simon A. Lee, Yuwei Zhang, Maxwell A. Xu, Zeinab Esmaeilpour 等 14 位作者
AI 速览：提出轻量级CGM基础模型GlucoFM，将血糖动态分解为慢变趋势与短期偏差双流，并在大规模无标签CGM数据上预训练，用于代谢表型分类与餐后血糖响应预测。
Continuous glucose monitoring (CGM) provides a dense view of daily metabolic physiology, yet existing generic time-series and CGM-specific foundation models often encode glucose traces as entangled single-stream sequences, leaving their multiscale temporal structure only implicitly modeled. We present GlucoFM, a lightweight CGM foundation model that aligns irregular recordings to a 24-hour chronological grid, preserves observation masks, and decomposes glucose dynamics into slow-varying glycemic trend and short-term deviation streams. GlucoFM is pretrained on 109,066 hours of unlabeled CGM recordings from 477 subjects with masked contextual latent prediction over fused daily representations and temporal dynamics prediction over the two streams. Frozen pre-fusion probes confirm distinct temporal emphasis: state tokens preferentially preserve hourly glucose level, whereas event tokens better retain short-term change. Across four diverse cohorts and seven phenotype-classification tasks, GlucoFM achieves the strongest subject-disjoint linear-probing performance among evaluated baselines, improving average PR-AUC by 4.1 points over the best CGM-specific foundation model, while also supporting strong cross-dataset transfer and few-shot adaptation. Its gains are most pronounced on core metabolic outcomes, leading PR-AUC on all diabetes-risk and $β$-cell dysfunction tasks and on 3 of 4 insulin-resistance tasks. Beyond phenotyping, when combined with recent CGM, meal nutrition, and subject context, the same frozen encoder achieves the lowest two-hour postprandial glycemic response errors among evaluated methods for trajectory, incremental area under the curve, peak rise, and peak timing. Together, these results demonstrate that GlucoFM learns reusable frozen CGM representations spanning metabolic phenotyping and context-conditioned glucose-response prediction.
Diffusion models have achieved remarkable progress in various domains with an intriguing ability to produce new data that do not exist in the training set. In this work, we study the hypothesis that such creativity arises from the neural network backbone learning a smoothed version of the empirical score function, which guides the denoising dynamics to generate data points that interpolate the training data. Focusing mainly on settings where the training set lies uniformly in a one-dimensional subspace, we elucidate the interplay between score smoothing and the denoising dynamics with analytical solutions and numerical experiments, demonstrating how smoothing the score function can cause the denoised data samples to interpolate the training set along the subspace. Moreover, we present theoretical and empirical evidence that learning score functions with neural networks - either with or without explicit regularization - can naturally achieve a similar effect, including when the data belong to simple nonlinear manifolds.
Girish Narayanswamy, Maxwell A. Xu, A. Ali Heydari, Samy Abdel-Ghaffar, Marius Guerard, Kara Vaillancourt, Zhihan Zhang, Jake Garrison 等 40 位作者
While ubiquitous wearable sensors capture a wealth of behavioral and physiological information, effectively transforming these signals into personalized health insights is challenging. Specifically, converting low-level sensor data into representations capable of characterizing higher-level states is difficult due to high phenotypic diversity and variation in individual baseline health, physiology, and lifestyle factors. Moreover, collecting wearable data paired with health outcome annotations is laborious and expensive, and retrospective annotation remains practically unfeasible, contributing to a scarcity of data with high-quality labels. To overcome these limitations, we propose a foundation model for wearable health that is pretrained on more than one trillion minutes of unlabeled sensor signals drawn from a large cohort of five million participants. We demonstrate that the joint scaling of model capacity and pretraining data volume leads to systematic improvements in performance, as evaluated on a diverse set of 35 health prediction tasks, spanning cardiovascular, metabolic, sleep, and mental health, as well as lifestyle choices and demographic factors. We find that this population scale representation unlocks label-efficient few-shot learning and generative capabilities for robust daily metric estimation. To further leverage this learned representation, we deploy a classroom of LLM agents to autonomously search the space of downstream predictive heads built on the model embeddings, showing broad performance improvements that increase with LLM model capacity. Finally, we show how integrating these downstream predictors into a Personal Health Agent can support model responses that are more relevant, contextually aware, and safe, and we validate this via 1,860 ratings from a cohort of clinicians.
Language Models Need Sleep: Learning to Self-Modify and Consolidate Memories
Ali Behrouz, Farnoosh Hashemi, Adel Javanmard, Vahab Mirrokni
AI 速览：受人类学习启发，提出“睡眠”范式，让语言模型通过记忆巩固与“做梦”过程持续学习并提升长期知识保持能力。
The past few decades have witnessed significant advances in the design of machine learning algorithms, from early studies on task-specific shallow models to more general deep Large Language Models (LLMs). Despite showing promising results in tasks that require instant prediction or in-context learning, existing models lack the ability to continually learn and effectively transfer their temporal in-context knowledge to their long-term parameters. Inspired by human learning process, we introduce a ''Sleep'' paradigm that allows the models to continually learn, distill their short-term fragile memories into stable long-term knowledge with replay, and recursively improve themselves with ''Dreaming'' process. In more detail, sleep consists of two stages: (1) Memory Consolidation: an upward distillation process, called Knowledge Seeding, where the memories of a smaller-self are distilled into a larger network to provide more capacity while preserving the knowledge. As a proof of concept, we present a new Generalized Distillation process for {Knowledge Seeding} (i.e., the combination of on-policy distillation with Reinforcement Learning (RL)-based imitation learning); (2) Dreaming: a self-improvement phase, where the model uses RL to generate a curriculum of synthetic data to rehearse new knowledge and refine existing capabilities without human supervision. Our experiments on long-horizon, continual learning, knowledge incorporation, and few-shot generalization tasks support the importance of the sleep stage.
Diagnosing and Mitigating Compounding Failures in Agentic Persuasion via Taxonomic Strategy Retrieval
Sana Ayromlou, Purvi Sehgal, Pradyumna Narayana
AI 速览：论文识别标准RAG的语义泄漏是智能体说服中复合失败的触发因素，并提出分类策略RAG（TS-RAG）来解耦论证结构与话题内容，从而提升逻辑迁移和轻量说服者的胜率。
Foundation-model agents in multi-step, open-ended environments frequently suffer from compounding errors, where early mistakes contaminate long-horizon trajectories. While Multi-Agent Debate (MAD) succeeds in deterministic domains, agents in subjective tasks like persuasion experience severe problem drift and sycophantic conformity. We identify semantic leakage in standard Retrieval-Augmented Generation (RAG) as a reproducible trigger for these failures, as standard RAG prioritizes vocabulary overlap over logical necessity. To eliminate this leakage, we introduce Taxonomic Strategy RAG (TS-RAG), a systems intervention that routes strategies through a discrete categorical bottleneck to decouple argumentative structure from topical content. Zero-shot, cross-domain evaluations demonstrate that TS-RAG significantly improves the transfer of abstract logic where standard semantic retrieval collapses. Crucially, TS-RAG acts as a "capability bridge" in asymmetric deployments, empowering lightweight persuaders to consistently defeat parametrically superior opponents (improving win rates from 70.5 to 78.5) and accelerating argumentative efficiency. Finally, we introduce trace-level diagnostics via a turn-by-turn Debate State Representation (DSR), demonstrating the necessity of strict constraints to prevent evaluation collapse via default agentic sycophancy.
Accelerating scientific discovery with Co-Scientist
Juraj Gottweis, Wei-Hung Weng, Alexander Daryin, Tao Tu, Petar Sirkovic, Artiom Myaskovsky, Grzegorz Glowaty, Felix Weissenberger 等 51 位作者
AI 速览：基于Gemini的多智能体系统Co-Scientist通过生成、批判和进化假设，在生物医学领域辅助科学家发现新知识。
Scientific discovery is driven by scientists generating novel hypotheses for complex problems that undergo rigorous experimental validation. To augment this process, we introduce Co-Scientist, a multi-agent AI system built on Gemini for structured scientific thinking and hypothesis generation. Co-Scientist aims to help scientists discover new original knowledge. Conditioned on their research objectives and prior scientific evidence, it formulates demonstrably novel research hypotheses for experimental verification. The system's design involves agents continuously generating, critiquing and refining hypotheses accelerated by scaling test-time compute. Key contributions include: (1) a multi-agent architecture with an asynchronous task execution framework for flexible compute scaling; (2) a tournament evolution process for self-improving hypotheses generation. Automated evaluations show continued benefits of test-time compute scaling, improving hypothesis quality over time. While general purpose, we focus the validation in three biomedical applications: drug repurposing, novel target discovery, and explaining mechanisms of anti-microbial resistance. Specifically, Co-Scientist helped identify new drug repurposing candidates and synergistic combination therapies for acute myeloid leukemia, which were validated through in vitro experiments. These real-world validations demonstrate the potential of Co-Scientist to accelerate scientific discovery and usher in an era of AI empowered scientists.
Towards Automating Scientific Review with Google's Paper Assistant Tool
Rajesh Jayaram, Drew Tyler, David Woodruff, Corinna Cortes, Yossi Matias, Vahab Mirrokni, Vincent Cohen-Addad
AI 速览：提出AI与人类在科学评审中协作的四级分类框架，并介绍用于深度科学评审与验证的智能体框架Paper Assistant Tool（PAT）。
Artificial intelligence is driving a revolution in scientific discovery, accelerating everything from hypothesis generation to mathematical theorem proving. However, this rapid acceleration is creating a systemic challenge: traditional human peer review cannot scale to match the influx of AI-assisted science. Ultimately, to resolve this tension, we must also deploy AI to accelerate the verification and review process itself. To frame the discussion around this transition, we propose a taxonomy consisting of four progressive levels of AI-human collaboration in scientific evaluation, and discuss various trade-offs involved with each. As a step toward this future, we introduce the Paper Assistant Tool (PAT), an agentic AI framework built for deep scientific review and verification. PAT ingests full scientific manuscripts and produces a comprehensive evaluation, checking theoretical results, validating experiments, suggesting improvements, and identifying potential flaws. By utilizing inference scaling techniques, PAT is able to identify deeper issues than a single model call alone, achieving a 34% improvement over zero-shot recall on mathematical errors in the SPOT benchmark. Pilot deployments of PAT as a pre-submission tool for authors at two major Computer Science conferences -- STOC and ICML -- demonstrate its ability to identify critical errors and suggest substantive improvements to research papers. By catching errors early, PAT eases the cognitive burden placed on referees, while preserving their control over the outcomes of the review process.
Nitay Calderon, Eyal Ben-David, Zorik Gekhman, Eran Ofek, Gal Yona
Standard factuality evaluations of LLMs treat all errors alike, obscuring whether failures arise from missing knowledge (empty shelves) or from limited access to encoded facts (lost keys). We propose a behavioral framework that profiles factual knowledge at the level of facts rather than questions, characterizing each fact by whether it is encoded, and then by how accessible it is: cannot be recalled, can be directly recalled, or can only be recalled with inference-time computation (thinking). To support such profiling, we introduce WikiProfile, a new benchmark constructed via an automated pipeline with a prompted LLM grounded in web search. Across 4 million responses from 13 LLMs, we find that encoding is nearly saturated in frontier models on our benchmark, with GPT-5 and Gemini-3 encoding 95--98% of facts. However, recall remains a major bottleneck: many errors previously attributed to missing knowledge instead stem from failures to access it. These failures are systematic and disproportionately affect long-tail facts and reverse questions. Finally, we show that thinking improves recall and can recover a substantial fraction of failures, indicating that future gains may rely less on scaling and more on methods that improve how models utilize what they already encode.
An AI Co-Data-Scientist for Prioritizing Candidate Biomarkers from Wearable Sensor Data
Yubin Kim, Salman Rahman, Samuel Schmidgall, Chunjong Park, A. Ali Heydari, Ahmed A. Metwally, Hong Yu, Xin Liu 等 36 位作者
AI 速览：CoDaS是一个在人类监督下整合多智能体假设生成、确定性统计分析、对抗性验证与文献解读的AI联合数据科学家，用于从可穿戴设备数据中优先筛选与心理健康和代谢终点相关的候选生物标志物关联。
Wearable devices generate continuous physiological and behavioral data, but converting these signals into clinically reviewable biomarker hypotheses remains labor-intensive. We introduce CoDaS, an AI co-data-scientist that integrates multi-agent hypothesis generation, deterministic statistical analysis, adversarial validation and literature-grounded interpretation under human oversight. Across three wearable cohorts comprising 9,279 participant-observations, CoDaS prioritized candidate associations for mental-health and metabolic endpoints after internal checks for replication, stability, robustness and leakage. The system identified related circadian-instability signals associated with depression, including sleep-duration variability in DWB ($ρ$ = 0.252, $p$ < 0.001) and sleep-onset variability in GLOBEM ($ρ$ = 0.126, $p$ < 0.001), and derived a wearable cardiovascular-fitness index associated with insulin resistance (steps/resting heart rate; $ρ$ = -0.374, $p$ < 0.001). Adding these features to demographic models produced modest gains ($ΔR^2$ = 0.040 for depression, 0.021 for insulin resistance). In a 12-clinician review totaling approximately 25 active hours, clinician validity judgments aligned with CoDaS confidence tiers ($ρ$ = 0.67, $p$ = 0.005), whereas added clinical value and confidence to act were rated lower. CoDaS supports traceable, hypothesis-generating prioritization of wearable candidate biomarkers.
ToolGrad: Efficient Tool-use Dataset Generation with Textual "Gradients"
Zhongyi Zhou, Kohei Uehara, Haoyu Zhang, Jingtao Zhou, Lin Gu, Ruofei Du, Zheng Xu, Tatsuya Harada
AI 速览：ToolGrad 提出“先答案后问题”的智能体框架，通过文本“梯度”迭代构造有效工具调用链，再反向合成用户查询，从而低成本生成高质量工具使用数据集。
Prior work synthesizes tool-use LLM datasets by first generating a user query, followed by complex tool-use annotations like depth-first search (DFS). This leads to inevitable annotation failures and low efficiency in data generation. We introduce ToolGrad, an agentic framework that inverts this paradigm. ToolGrad first constructs valid tool-use chains through an iterative process guided by textual "gradients", and then synthesizes corresponding user queries. This "answer-first" approach led to ToolGrad-500, a dataset generated with more complex tool use, lower cost, and almost 100% pass rate. Experiments show that ToolGrad models outperform those trained on expensive baseline datasets and proprietary LLMs. The ToolGrad source code, dataset, and models are available at https://github.com/zhongyi-zhou/toolgrad.
Inference providers must maintain availability for many LLMs, including low-volume but essential models, making resource efficiency increasingly important as token prices fall. Analysis of production traces reveals a dynamic bursty-group pattern in which sets of models become active together and shift over time; existing space- and time-sharing approaches lack principled mechanisms to adapt to this variability, forcing trade-offs between SLO adherence and efficiency. We observe that elastic memory allocation can unify spatial and temporal sharing. Based on this insight, we have developed Prism, a memory-centric LLM co-serving framework that applies memory ballooning to reclaim memory across models and support both forms of sharing under a single scheme. Prism's balloon driver, referred to as kvcached, has been open-sourced at https://github.com/ovg-project/kvcached, and deployed in production environments across 10K+ GPUs.
Maria Despoina Siampou, Shushman Choudhury, Shang-Ling Hsu, Neha Arora, Cyrus Shahabi
Recent progress in geospatial foundation models highlights the importance of learning general-purpose representations for real-world locations, particularly points-of-interest (POIs) where human activity concentrates. Existing approaches, however, focus primarily on place identity derived from static textual metadata, or learn representations tied to trajectory context, which capture movement regularities rather than how places are actually used (i.e., POI's function). We argue that POI function is a missing but essential signal for general POI representations. We introduce Mobility-Embedded POIs (ME-POIs), a framework that augments POI embeddings derived, from language models with large-scale human mobility data to learn POI-centric, context-independent representations grounded in real-world usage. ME-POIs encodes individual visits as temporally contextualized embeddings and aligns them with learnable POI representations via contrastive learning to capture usage patterns across users and time. To address long-tail sparsity, we propose a novel mechanism that propagates temporal visit patterns from nearby, frequently visited POIs across multiple spatial scales. We evaluate ME-POIs on five newly proposed map enrichment tasks, testing its ability to capture both the identity and function of POIs. Across all tasks, augmenting text-based embeddings with ME-POIs consistently outperforms both text-only and mobility-only baselines. Notably, ME-POIs trained on mobility data alone can surpass text-only models on certain tasks, highlighting that POI function is a critical component of accurate and generalizable POI representations.
Rory Sayres, Kejia Chen, Ayush Jain, Matthew Thompson, Jonathan Richina, Xiang Yin, Jimmy Hu, Fan Zhang 等 22 位作者
Patient-managed Personal Health Records (PHRs) promises to empower patients to better understand their health; but information in the record is complex, potentially hindering insights. In this study, we assess the potential of large language models (LLMs, Gemini 3.0 Flash) to provide helpful answers to user health queries, when provided clinical data from PHRs as context. A total of 2,257 user queries were drawn from 3 different distributions to represent patient questions: shorter web search queries, longer questions derived from templates of chatbot conversations, and questions patients asked to their healthcare team (patient calls). Queries were matched with de-identified PHRs (from a pool of 1,945). Gemini responses were generated (1) without PHR context; (2) with a basic summary of demographics, conditions, and medications; (3) with full, extensive clinical notes. For evaluation, we leveraged an existing rating framework (SHARP), and developed a new framework for specific error modes when interpreting PHRs. Evaluation was performed using autoraters for the full set, and with clinician ratings for a subset (n=95), with both sets of raters knowing the full PHR context. We see significant improvements in the helpfulness of answers to all question types with PHR data (p < 0.001, paired t-test). We also observe potential gains in safety, accuracy, relevance and personalization of answers. Our PHR evaluation framework further identifies gaps in LLM understanding of particular aspects of complex PHRs, such as temporal disorientation, and rare but meaningful confabulations. These results suggest potential for PHR data to help people with a wide range of user needs; and provide a framework for monitoring for gaps in LLM answers based on PHR context. This study motivates further work to assess and realize potential benefits to users from understanding their health records.
Autonomous research agents produce competitive solutions and professional-looking manuscripts, yet their outputs contain verifiability failures undetectable by surface-level evaluation: fabricated citations, unreproducible scores, and method descriptions that diverge from the implementation. We address this through three contributions. First, Chain-of-Evidence (CoE), a verifiability framework requiring every claim to be traceable to its evidence source. Second, ScientistOne, an end-to-end autonomous research system that maintains evidence chains by construction throughout literature review, solution discovery, and paper writing. Third, CoE Audit, a post-hoc audit whose four integrity checks -- score verification, specification violation, reference verification, and method-code alignment -- apply uniformly to all systems. Across 75 papers spanning five systems and five frontier research tasks, every baseline exhibits at least one systematic failure mode: hallucinated reference rates reach 21%, score verification passes in as few as 42% of papers, and method-code alignment ranges from 20% to 80%. ScientistOne achieves zero hallucinated references (0/337), perfect score verification (12/12), and the highest method-code alignment (14/15), while matching or exceeding human expert performance on all five tasks. ScientistOne further generalizes to six additional tasks spanning medical imaging, fine-grained recognition, 3D perception, and language modeling, achieving state-of-the-art on Parameter Golf and gold medals on MLE-Bench tasks where baselines fail entirely.
Jiaqi Liu, Shi Qiu, Mairui Li, Bingzhou Li, Haonian Ji, Siwei Han, Xinyu Ye, Peng Xia 等 36 位作者
Automating scientific discovery requires more than generating papers from ideas. Real research is iterative: hypotheses are challenged from multiple perspectives, experiments fail and inform the next attempt, and lessons accumulate across cycles. Existing autonomous research systems often model this process as a linear pipeline: they rely on single-agent reasoning, stop when execution fails, and do not carry experience across runs. We present AutoResearchClaw, a multi-agent autonomous research pipeline built on five mechanisms: structured multi-agent debate for hypothesis generation and result analysis, a self-healing executor with a \textsc{Pivot}/\textsc{Refine} decision loop that transforms failures into information, verifiable result reporting that prevents fabricated numbers and hallucinated citations, human-in-the-loop collaboration with seven intervention modes spanning full autonomy to step-by-step oversight, and cross-run evolution that converts past mistakes into future safeguards. On ARC-Bench, a 25-topic experiment-stage benchmark, AutoResearchClaw outperforms AI Scientist v2 by 54.7%. A human-in-the-loop ablation across seven intervention modes reveals that precise, targeted collaboration at high-leverage decision points consistently outperforms both full autonomy and exhaustive step-by-step oversight. We position AutoResearchClaw as a research amplifier that augments rather than replaces human scientific judgment. Code is available at https://github.com/aiming-lab/AutoResearchClaw.
Eser Aygün, Anastasiya Belyaeva, Gheorghe Comanici, Marc Coram, Hao Cui, Jake Garrison, Renee Johnston Anton Kast, Cory Y. McLean 等 42 位作者
The cycle of scientific discovery is frequently bottlenecked by the slow, manual creation of software to support computational experiments\cite{hannay2009how}. To address this, we present Empirical Research Assistance (ERA), an AI system that creates expert-level scientific software whose goal is to maximize a quality metric. The system uses a Large Language Model (LLM) and Tree Search (TS)\cite{silver2016mastering} to systematically improve the quality metric and intelligently navigate the large space of possible solutions. ERA achieves expert-level results when it explores and integrates complex research ideas from external sources. The effectiveness of tree search is demonstrated across a diverse range of tasks. In bioinformatics, ERA discovered 40 novel methods for single-cell data analysis that outperformed the top human-developed methods on a public leaderboard. In epidemiology, ERA generated 14 models that outperformed the CDC ensemble and all other individual models for forecasting COVID-19 hospitalizations. ERA also produced expert-level software for geospatial analysis, neural activity prediction in zebrafish, and numerical solution of integrals, and a novel rule-based construction for time series forecasting. By devising and implementing novel solutions to diverse tasks, ERA represents a significant step towards accelerating scientific progress.
We present a case study for how AI coding systems can be used to generate novel scientific hypotheses. We combine a generic coding agent (Google's AntiGravity) with an LLM-driven tree search algorithm (Empirical Research Assistance / ERA) to autonomously generate high-efficiency three-dimensional photovoltaic (3DPV) structures that overcome losses limiting flat solar panels at mid-latitudes. These structures operate by presenting favorable angles to the sun throughout the day, and for illustrative purposes we focus on optimizing performance for a single solar day. Our workflow begins by using AntiGravity to reproduce calculations \cite{bernardi2012solar} showing that 3DPV can have energy densities much higher than stationary flat PV panels. We use these initial designs as the starting point for large scale tree search, where we seek improved solutions and score them for their diurnal yield. The initial tree search leads to nominally more efficient solutions, yet they are caused by algorithmic reward hacking, arising from non-physical design features such as structurally levitating disconnected tiers and exploitations of the discretizations in the optics solver. To counteract this, we develop a workflow where the coding agent iteratively patches the physics engine with constraints to eliminate reward hacking. With reward-hacking eliminated, ERA discovers a series of designs with various constraints and improved performance, including optimal designs with different fixed collector areas, optimizing zenith tracking and avoiding self shadowing. Combining coding agents with tree search (ERA) provides a powerful platform for scientific discovery, for problems whose solutions can be empirically evaluated with a score function.
Peer review is fundamental to the integrity and advancement of scientific publication. Traditional methods of peer review analyses often rely on exploration and statistics of existing peer review data, which do not adequately address the multivariate nature of the process, account for the latent variables, and are further constrained by privacy concerns due to the sensitive nature of the data. We introduce AgentReview, the first large language model (LLM) based peer review simulation framework, which effectively disentangles the impacts of multiple latent factors and addresses the privacy issue. Our study reveals significant insights, including a notable 37.1% variation in paper decisions due to reviewers' biases, supported by sociological theories such as the social influence theory, altruism fatigue, and authority bias. We believe that this study could offer valuable insights to improve the design of peer review mechanisms. Our code is available at https://github.com/Ahren09/AgentReview.
Joseph Breda, Fadi Yousif, Beszel Hawkins, Marinela Cotoi, Miao Liu, Ray Luo, Po-Hsuan Cameron Chen, Mike Schaekermann 等 33 位作者
Language models excel at diagnostic assessments on curated medical case-studies and vignettes, performing on par with, or better than, clinical professionals. However, existing studies focus on complex scenarios with rich context making it difficult to draw conclusions about how these systems perform for patients reporting symptoms in everyday life. We deployed SymptomAI, a set of conversational AI agents for end-to-end patient interviewing and differential diagnosis (DDx), via the Fitbit app in a study that randomized participants (N=13,917) to interact with five AI agents. This corpus captures diverse communication and a realistic distribution of illnesses from a real world population. A subset of 1,228 participants reported a clinician-provided diagnosis, and 517 of these were further evaluated by a panel of clinicians during over 250 hours of annotation. SymptomAI DDx were significantly more accurate (OR = 2.56, p < 0.001) than those from independent clinicians given the same dialogue in a blinded randomized comparison. Moreover, agentic strategies which conduct a dedicated symptom interview that elicit additional symptom information before providing a diagnosis, perform substantially better than baseline, user-guided conversations (p < 0.001). An auxiliary analysis on 1,509 conversations from a general US population panel validated that these results generalize beyond wearable device users. We used SymptomAI diagnoses as labels for all 13,917 participants to analyze over 500,000 days of wearable metrics across nearly 400 unique conditions. We identified strong associations between acute infections and physiological shifts (e.g., OR > 7 for influenza). While limited by self-reported ground truth, these results demonstrate the benefits of a dedicated and complete symptom interview compared to a user-guided symptom discussion, which is the default of most consumer LLMs.
Paraphrase-Induced Output-Mode Collapse: When LLMs Break Character Under Semantically Equivalent Inputs
Aofan Liu, Jingxiang Meng
AI 速览：作者报告，语义等价但措辞不同的提示改写会让大语言模型放弃原本要求的封闭式输出格式，转而输出对话式散文，从而在精确匹配评测中被误判。
When the substantive content of a request is rewritten, do large language models still answer in the format the original task asked for? We find that they often do not, even at temperature zero. On a 150-query evaluation over five compact 2025-era LLMs and four task types, we observe a systematic failure mode we call prompt-variant output-mode collapse: when a closed-form prompt asks for a bare label or a single choice token, content-preserving prompt variants can push the model into conversational prose, the requested format dissolves, and exact-match evaluation pipelines silently misjudge the result. To make this measurable, we release PARACONSIST, a 900-prompt benchmark of 150 base queries with five lexical, syntactic, and semantic-expansion prompt variants each, and a Semantic Consistency Score that decomposes prompt-variant robustness into answer consistency, sentence-BERT semantic similarity, and length stability. Under a whole-word answer-set match, only ~22% of closed-form variant responses preserve the ground-truth label inside their output, while ~78% drift away from the answer space entirely. In our pool, the dominant predictor of collapse is task structure rather than model identity, with model differentiation jointly carried by answer consistency and length stability. Robustness audits should therefore track response-mode preservation as a first-class reliability target alongside answer accuracy.
A$^2$RD: Agentic Autoregressive Diffusion for Long Video Consistency
Do Xuan Long, Yale Song, Min-Yen Kan, Tomas Pfister, Long T. Le
AI 速览：提出 A²RD，将长视频合成拆解为“检索—合成—精炼—更新”的闭环智能体自回归扩散流程，以缓解长时程语义漂移与叙事崩塌。
Synthesizing consistent and coherent long video remains a fundamental challenge. Existing methods suffer from semantic drift and narrative collapse over long horizons. We present A$^2$RD, an Agentic Auto-Regressive Diffusion architecture that decouples creative synthesis from consistency enforcement. A$^2$RD formulates long video synthesis as a closed-loop process that synthesizes and self-improves video segment-by-segment through a Retrieve--Synthesize--Refine--Update cycle. It comprises three core components: (i) Multimodal Video Memory that tracks video progression across modalities; (ii) Adaptive Segment Generation that switches among generation modes for natural progression and visual consistency; and (iii) Hierarchical Test-Time Self-Improvement that self-improves each segment at frame and video levels to prevent error propagation. We further introduce LVBench-C, a challenging benchmark with non-linear entity and environment transitions to stress-test long-horizon consistency. Across public and LVBench-C benchmarks spanning one- to ten-minute videos, A$^2$RD outperforms state-of-the-art baselines by up to 30% in consistency and 20% in narrative coherence. Human evaluations corroborate these gains while also highlighting notable improvements in motion and transition smoothness.
Hada Melino Muhammad, Zechen Li, Flora Salim, Ahmed A. Metwally
AI 速览：提出预测掩码潜在表征的自监督预训练框架 CGM-JEPA 及其跨视图扩展 X-CGM-JEPA，用于学习可跨模态迁移的连续血糖监测表征。
Continuous Glucose Monitoring (CGM) can detect early metabolic subphenotypes (insulin resistance, IR; $β$-cell dysfunction), but population-scale deployment faces two coupled problems. First, the same physiological state appears through multiple views (CGM time series, venous OGTT, Glucodensity summaries), so single-view representations fail to transfer when deployment shifts the modality or setting. Second, baselines perform inconsistently across these shifts. Both problems point to one remedy: representations that abstract away from any single view to capture higher-level temporal and distributional structure. We propose CGM-JEPA, a self-supervised pretraining framework which predicts masked latent representations rather than raw values, yielding abstraction that transfers across modalities. X-CGM-JEPA adds a masked Glucodensity cross-view objective for complementary distributional information. We pretrain on $\sim$389k unlabeled CGM readings from 228 subjects and evaluate on two clinical cohorts ($N=27$ and $N=17$ public-release subsets) across three regimes (cohort generalization, venous-to-CGM transfer, home CGM) under 20-iteration $\times$ 2-fold cross-validation. X-CGM-JEPA ranks first or second on AUROC for both endpoints across all three regimes while no baseline does, exceeding the strongest baseline by up to $+6.5$ pp in cohort generalization and $+3.6$ pp in venous-to-CGM transfer (paired Wilcoxon, $p<0.001$). Under modality shift, it matches mean AUROC while redistributing toward weaker subgroups (ethnicity AUROC gap shrinks 25-54%); on sparse in-domain venous data, the distributional view lifts label-aware clustering (ARI $+39\%$, NMI $+40\%$). Code and weights: https://github.com/cruiseresearchgroup/CGM-JEPA