Designing healthcare strategies requires anticipating their clinical and operational consequences before implementation, a task that often relies on health system simulation. Such a simulation necessitates modeling how patient states evolve and generate care demands. However, conventional approaches typically tailor compact state transitions to a single policy question and omit history-dependent dynamics, thus requiring the redefinition of states and transitions when there is a new question that entails different clinical information. We propose to learn a patient world model from longitudinal EHRs using a neural network to provide a shared clinical representation of patient trajectories that can serve simulation questions across scenarios. Taking ICU operations as an example, we train the model on MIMIC-IV, freeze it, and couple its time-queryable predictions to shared ICU calendars, resources, and queues via scenario-specific mappings, so that one model renders admission demand, care tasks, and discharge proposals across simulations evaluating ICU bed capacity, care dispatch, and post-ICU transfer capacity. Experiments show that our model matches Markov and semi-Markov comparators in aggregate occupancy and directional responses to capacity and dispatch policies. It also reproduces policy gains from replayed observed trajectories. For patients entering the same support state from different prior trajectories, the learned representation captures a 24-h recovery difference (-6.4 predicted versus -6.7 observed percentage points), a contrast missed by compact state models, which propagates into distinct simulated care demand, queue burden, and bed use. These results indicate that a learned world model of patient dynamics has the potential to replace question-specific state models, allowing new care policies to be evaluated by reconfiguring the scenario without model rebuilding.
Current medical benchmarks typically break down clinical competence into isolated factual questions, single-image tasks, or static case vignettes. These tests score individual answers, but reveal less about whether a model can integrate subspecialty knowledge with multimodal evidence and track a patient's condition throughout a course of care. To close this gap, we introduce NPCBench, a clinical apprenticeship benchmark for nasopharyngeal carcinoma (NPC). NPCBench mirrors specialist training, from guideline and foundational knowledge to case planning, longitudinal review, CarePath integration, and open-ended consultation. It contains 4,777 component and consultation items and a 100-patient CarePath cohort with 417 scored diagnostic and care tasks. The episode-level evaluation tests whether diagnostic and care answers are jointly correct within a care pathway. By linking stepwise tasks to patient-level care trajectories, NPCBench evaluates whether models ground decisions in visual evidence, interpret changes in patient state, and meet clinical requirements in consultation. Across 30 evaluated models, we observe a composition gap: strong performance on individual tasks does not ensure jointly correct diagnostic and care answers for the same patient. Among 21 multimodal models, strict CarePath success reaches at most 23%. Paired controls and physician calibration further examine evidence grounding, longitudinal revision, and consultation judging. Overall, NPCBench broadens the evaluation of medical artificial intelligence beyond static question-answering paradigms to an apprenticeship-oriented assessment of clinical workflows, thereby offering a testbed for evidence-based and temporally coherent reasoning in oncology care.
As one of the most important underwater sensing technologies, forward-looking sonar exhibits unique imaging characteristics. Sonar images are often affected by severe speckle noise, low texture contrast, acoustic shadows, and geometric distortions. These factors make it difficult for traditional teacher-student frameworks to achieve satisfactory performance in sonar semantic segmentation tasks under extremely limited labeled data conditions. To address this issue, we propose a Collaborative Teacher Semantic Segmentation Framework for forward-looking sonar images. This framework introduces a multi-teacher collaborative mechanism composed of one general teacher and multiple sonar-specific teachers. By adopting a multi-teacher alternating guidance strategy, the student model can learn general semantic representations while simultaneously capturing the unique characteristics of sonar images, thereby achieving more comprehensive and robust feature modeling. Considering the challenges of sonar images, which can lead teachers to generate a large number of noisy pseudo-labels, we further design a cross-teacher reliability assessment mechanism. This mechanism dynamically quantifies the reliability of pseudo-labels by evaluating the consistency and stability of predictions across multiple views and multiple teachers, thereby mitigating the negative impact caused by noisy pseudo-labels. Notably, on the FLSMD dataset, when only 2% of the data is labeled, our method achieves a 5.08% improvement in mIoU compared to other state-of-the-art approaches.
AI agents are playing an increasingly important role in physics research. However, existing physics benchmarks only evaluate fixed questions, isolated sub-tasks, or paper reproduction with given solutions, and rarely check research quality alongside correctness. We introduce FrontierPhysics, an end-to-end benchmark with 56 tasks made by 42 physicists based on their own research, covering nine domains across theoretical, computational, and experimental physics. Each task requires agents to review the literature, develop a research plan, conduct research and experiments, and produce structured outputs and scientific manuscripts. Combining deterministic verifiers with expert-authored rubrics, FrontierPhysics evaluates whether agents' research is correct and publishable. Across 22 models in 26 configurations, no configuration passes more than 46 of its 168 rollouts. Manual review of agent trajectories shows that frontier agents' main weaknesses are insufficiently rigorous reasoning and limited expert intuition, rather than gaps in physics knowledge or execution errors.
Autoregressive image generation has recently emerged as a competitive visual generation paradigm, yet its generation order is often predefined or heuristic, such as next-patch prediction, random-order prediction, or one-step generation for specific scales. We observe that these strategies can cause models to overlook important structural dependencies in images, thereby limiting both structural robustness and reasoning capability. In this work, we propose a context-aware autoregressive generation framework, where the model dynamically determines the next token location based on global context and current local information. Rather than following a fixed or random order, our method allows the generation process to adapt to image structure and semantic dependencies. Extensive experiments show that context-aware generation significantly improves structural robustness across different image AR paradigms, including masked autoregressive and scale-wise autoregressive models. Beyond quantitative improvements, we further observe emerging reasoning properties: the model can better understand complex semantic instructions and generate images that more faithfully follow the given guidance. These findings suggest that generation order is a critical yet underexplored factor in image autoregressive modeling, and that context-aware decoding can unlock stronger reasoning-aware visual generation capabilities. Code is available at https://github.com/Hpesojyjx/Saccades-AR.
We study context-aware time-series forecasting, in which a single target variable is predicted from its own history and a set of contextual variables, such as weather and calendar information. As the context becomes more diverse, a single model struggles to capture all of its regimes, while ensemble learning and Mixture-of-Experts approaches rely on manual data partitioning or soft routing, which increases the inference cost and hinders interpretability. We propose CATF, a Context-Aware Time-Series Forecasting framework built on a Manager-Worker architecture: a Transformer-based Manager routes each input to a single Worker based on the context, using hard routing during both training and inference. The Workers thus specialize without manual data partitioning, and any single-model forecaster can serve as a Worker. On five context-rich datasets, four horizons, and two normalization schemes, CATF improves over its standalone counterpart in 162 of 200 comparisons, the best CATF-enhanced model outperforms the best standalone baseline in 19 of 20 settings, and it outperforms the zero-shot Time-MoE foundation model in 15 of 20 settings. A case study on bike-sharing data shows that the Manager routes inputs by the calendar and that each Worker specializes in a different weekly pattern.
Unified Multimodal Models (UMMs) integrate visual understanding, generation, and editing within a single unified framework. However, existing unified multimodal datasets and benchmarks remain dominated by single-turn tasks. Even in recent multi-turn datasets, many turns can be solved independently without tracking information across turns. Consequently, they provide limited supervision and evaluation for multimodal stateful interaction, which requires models to understand, maintain, update, and faithfully realize evolving dialogue states across turns. To address this gap, we introduce YANAMI, the first large-scale multimodal dialogue dataset and benchmark for stateful interaction, comprising YANAMI-400K and YANAMI-Bench. YANAMI-400K contains 400K multi-turn multimodal dialogues, with more than 2M images and 2.6M dialogue turns. The dialogues span four representative scenarios: Multi-Image Fusion, Image Editing, World Modeling, and Visual Reasoning, and require models to continuously track, preserve, and revise evolving multimodal dialogue states across turns. YANAMI-Bench comprises 400 multi-turn dialogues for systematically evaluating multimodal stateful interaction. It jointly evaluates Dialogue State Understanding and Visual Realization, characterizing the gap between models' ability to understand evolving dialogue states and their ability to faithfully realize them in visual outputs. Experiments show that fine-tuning BAGEL on YANAMI-400K improves image editing, generation, and multimodal stateful interaction by 10.3%, 2.0%, and 13.23%, respectively, while preserving its general visual understanding capabilities. Evaluations on YANAMI-Bench further reveal that existing UMMs still struggle to maintain, update, and visually realize evolving multimodal dialogue states.
Antibody affinity maturation is a natural optimization process in which B cells acquire mutations through somatic hypermutation (SHM), undergo selection for improved antigen binding, and iteratively evolve toward higher affinity. Computationally modeling this process requires capturing both biologically plausible mutations and antigen-specific selection. However, existing mutation models do not directly optimize binding, while affinity optimization often neglects realistic mutation trajectories. We introduce iGC (in silico Germinal Centers), a two-stage reinforcement learning (RL) framework for antigen-specific antibody optimization. Stage 1 learns an SHM mutation prior from parent-child pairs in B-cell lineage trees and adapts it to a target affinity-maturation dataset. Stage 2 initializes an RL policy from this prior and optimizes antigen binding with Kullback-Leibler (KL) regularization toward the frozen prior. To prevent reward exploitation, including repetitive high-reward substitutions and structurally tolerated framework mutations, we introduce a Reward-Tax Meta-Gradient objective. RewardNet smooths the affinity landscape, while TaxNet penalizes reward overexploitation, jointly defining a learned meta-reward for policy optimization. We evaluate iGC on mutation prediction, SHM consistency, affinity optimization, and mutation diversity. The mutation prior more than doubles the strongest baseline in mutation-site prediction. Following RL optimization, iGC maintains SHM sequence structure. It also achieves a strong exploration-exploitation balance, yielding competitive reward-diversity products across candidate-selection cutoffs. These results demonstrate that iGC integrates biologically plausible mutation generation with antigen-specific affinity selection, providing an in silico framework for iterative antibody affinity maturation.
We introduce Continuous-Action World Models (CoAWM), a framework for learning cross-embodiment spatiotemporal dynamics priors that support robot action generation across embodiments and execution frequencies. At its core is a shared latent function space that captures the spatial and temporal structure of robot actions. We learn this space through two stages. First, function pretraining brings trajectories from different embodiments and sampling frequencies into a common representation, learning shared dynamics priors through action reconstruction and consistency across temporal sampling views. By accommodating heterogeneous robot trajectories, this stage broadens the range of data sources available for pretraining and facilitates scaling to larger and more diverse datasets. Second, we connect the pretrained function space to a world-model backbone, enabling observations, language instructions, and the current robot state to condition the prediction of a latent action function. A single decoder takes any query time and returns the corresponding end-effector action. By separating shared dynamics priors from task-conditioned action selection and temporal sampling, our approach provides a unified foundation for transferring robot experience across embodiments and control frequencies.
Discrete visual tokens represent vision in a discrete form analogous to language, offering a native interface for multimodal modeling under a shared next-token prediction objective. However, quantization error is widely assumed to cause unavoidable semantic loss, fundamentally limiting the semantic fidelity of discrete visual tokens and positioning continuous visual representations as an intrinsic upper bound. Using multimodal understanding as a proxy for semantic fidelity, we revisit this assumption and find quantization error unreliable, as discrete representations with substantially larger errors can achieve better understanding. Instead, the effective bit budget of discrete indices emerges as a key determinant of downstream performance. However, existing quantizers eventually saturate as additional codebooks contribute progressively less semantic information. As one approach to alleviating this saturation, we introduce Factorized Vector Quantization, which quantizes complementary, fixed-dimensional views of the visual feature with symmetric parallel codebooks. It continues to improve at larger bit budgets, ultimately matching continuous visual representations in multimodal understanding. Trained on industrial-scale multimodal data, our model achieves state-of-the-art performance among discrete-representation models, outperforming UniAR and Emu3-Chat by 22.8% and 59.2%, respectively, on a nine-metric average. To our knowledge, it is also the first discrete-representation model competitive with strong continuous-representation models such as Qwen3-VL, including on fine-grained OCR tasks. We further identify the key principles and a practical recipe enabling this competitiveness. These results and insights support the potential of discrete visual representations to underpin large-scale native multimodal foundation models. Code and models are available at https://github.com/hustvl/FVQ