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新论文 · v1arXiv:2611.07054

Reclassification Is All You Missed: Surfacing Variant Reinterpretation Need in Online Health Communities at Population Scale

Kamalakkannan Ravi, Mengshu Nie, Annapurna Poduri, Cong Liu

原文摘要

Genetic variants are routinely reclassified in ClinVar after a patient is tested, sometimes from uncertain to pathogenic, yet patient recontact is inconsistent, with no clear duty and responsibility diffused among labs, providers, and patients. Many affected people discuss their results in public online health communities that clinical recontact often does not reach. We built PRISM, an agentic large-language-model pipeline that screens these posts, checks whether the variant was later reclassified, and drafts a disclaimer-bearing outreach message, in a no-contact dry run. Across 3.9 million posts from 32 communities, agent-predicted reinterpretation-relevant discussion is rare (0.288%) but concentrated in specialist genetics communities (6.30% versus 0.10% in general medical-advice communities) and growing fivefold since 2014; PRISM surfaces 123 candidate classification differences, 5 of them from an uncertain submission to pathogenic or likely pathogenic. On a held-out set of 30 real-post drafts, a clinician judged 27 factually grounded and 15 fit to send: factual accuracy is necessary but not sufficient for clinically acceptable outreach. PRISM contributes a population-scale reinterpretation-need map with code and data to be released upon publication.

cs.CL · cs.AI · cs.CY · q-bio.GN

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arXiv ↗PDF ↗
版本更新 · v2arXiv:2609.10092

RAP: Research Attention Prediction in Language Agents

Yingqian Wu, Jingcong Liang, Shengbin Yue, Siyuan Wang, Zhenfei Yin, Junchi Yu, Zhongyu Wei

原文摘要

LLM agents increasingly support research planning and execution, where judgments about current and anticipated research activity inform decisions. Yet whether they can infer changes across a whole field from the partial evidence they retrieve through online scholarly search remains unclear. We introduce Research Attention Prediction (RAP), a literature search benchmark for evaluating this ability. We build a local search environment from 356,357 dated arXiv papers and construct two complementary evaluation tasks. The benchmark comprises a Core set of 2,160 questions across 54 AI/ML fields and an Extended set covering 269 fields. Our evaluation and analysis of LLM agents show that search substantially improves stronger agents' recognition of recent changes, while forecasting gains remain limited or negative. Agents update forecasts across dates and adjust their investigations to forecasting goals, but these adaptations do not reliably yield accurate predictions of future shifts. Even for recent changes, final judgments can diverge from what the retrieved papers indicate. These findings show that agents can recognise some recent changes, yet reliably anticipating future research activity remains difficult despite changes in their answers and investigations.

cs.AI · cs.CL

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arXiv ↗PDF ↗
首次观测 · 记录 #1ACL Anthology · ACL 2026:acl:2026.acl-long.1651ACL Anthology · ACL 2026

Debate-of-Thoughts: Resolving Knowledge Conflicts in LLMs Through Internal Deliberation

Guocong Li, Qirui Hu, Ping Wang Renmin University of China, Guofeng Zhang InSpatio and Zhejiang University, Jian Wu Zhejiang University, Hongxia Xu Zhejiang University

原文摘要

Large Language Models enhanced with Retrieval Augmented Generation show strong potential in knowledge intensive tasks. However, they often encounter knowledge conflicts, where retrieved information contradicts the model’s internal knowledge or exhibits internal inconsistencies. Existing methods treat this as a simplistic binary choice, forcing models to blindly trust external contexts or rigidly rely on memory, resulting in unreliable predictions that swing between sycophancy and stubbornness. We argue that a more principled approach is to embrace contradictions as opportunities for deeper reasoning. To this end, we introduce Debate-of-Thoughts (DoT), a framework that transforms conflict resolution into an active deliberation process. DoT guides a single model through three phases: 1) hypothesis generation, which forms competing perspectives; 2) internal debate, where the model acts as both a proponent and a critic to stress test each view; and 3) adjudication, where a judge module evaluates arguments based on evidence and logical consistency. We implement DoT via two complementary strategies: inference time prompt chaining and supervised fine tuning. Experiments across multiple conflict benchmarks show that DoT consistently outperforms state-of-the-art methods, while generating transparent debate transcripts that explain its decisions. By improving both accuracy and interpretability under knowledge conflicts, DoT establishes a more reliable paradigm for retrieval augmented generation systems.

cs.CL

Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表

首次观测 · 记录 #1ACL Anthology · ACL 2026:acl:2026.acl-long.1904ACL Anthology · ACL 2026

Beyond Static Alignment: Adaptive Arbitration for Semantic Incongruence in Semi-Supervised Multimodal Sentiment Analysis

Huicong Li, Xiangbo Ji, Wei Wu Inner Mongolia University

原文摘要

Multimodal sentiment analysis is fundamentally challenged by semantic incongruence, where ambiguous visual signals often conflict with explicit textual cues. In semi-supervised scenarios, naively fusing such noisy features contaminates the joint representation, while conventional static alignment strategies fail to effectively arbitrate conflicting modalities in this task, leading to error reinforcement during self-training. To this end, we propose a novel Adaptive Arbitration for Semantic Incongruence (A2SI) framework for semi-supervised multimodal sentiment analysis, which emphasizes stable cross-modal representations and reliable supervision. Specifically, we first constrain unreliable visual representations by leveraging the reliable textual modality as an anchor to align divergent embeddings and reduce representation noise. Based on this, we further consider the reliability of supervision signals and calibrate pseudo-labels by adaptively weighting evidentiary confidence from heterogeneous views. Finally, to prevent error accumulation caused by unreliable samples, we introduce a progressive arbitration mechanism that verifies pseudo-labeled data from dual perspectives, enabling the model to dynamically balance sample diversity and label purity throughout self-training. Extensive experiments on the MVSA-Single and MVSA-Multiple datasets demonstrate that A2SI consistently outperforms state-of-the-art methods under label-limited settings.

cs.CL · cs.CV

Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表

首次观测 · 记录 #1ACL Anthology · ACL 2026:acl:2026.acl-long.2035ACL Anthology · ACL 2026

RATE: Reviewer Profiling and Annotation-free Training for Expertise Ranking in Peer Review Systems

Weicong Liu, Zixuan Yang, Yibo Zhao East China Normal University, Xiang Li East China Normal University

原文摘要

Reviewer assignment is increasingly critical yet challenging in the LLM era, where rapid topic shifts render many pre-2023 benchmarks outdated and where proxy signals poorly reflect true reviewer familiarity. We address this evaluation bottleneck by introducing LR-bench, a high-fidelity, up-to-date benchmark curated from 2024–2025 AI/NLP manuscripts with five-level self-assessed familiarity ratings collected via a large-scale email survey, yielding 1,055 expert-annotated paper–reviewer–score annotations. We further propose a reviewer-centric ranking framework that distills each reviewer’s recent publications into compact keyword-based profiles and fine-tunes an embedding model with weak preference supervision constructed from heuristic retrieval signals, enabling to match each manuscript against a reviewer profile directly. Across the LR-bench and the CMU gold-standard dataset, our approach consistently achieves state-of-the-art performance, outperforming strong embedding baselines by a clear margin. We release LR-bench at https://huggingface.co/datasets/Gnociew/LR-bench, and an github repository at https://github.com/Gnociew/RATE-Reviewer-Assignment.

cs.CL

Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表

首次观测 · 记录 #1ACL Anthology · ACL 2026:acl:2026.acl-long.576ACL Anthology · ACL 2026

No More Stale Feedback: Co-Evolving Critics for Open-World Agent Learning

Zhicong Li, Lingjie Jiang Peking University, Yulan Hu Alibaba Group, Xingchen Zeng, Yixia Li, Xiangwen Zhang, Guanhua Chen Southern University of Science and Technology, Zheng Pan Alibaba Group 等 10 位作者

原文摘要

Critique-guided reinforcement learning (RL) has emerged as a powerful paradigm for training LLM agents by augmenting sparse outcome rewards with natural-language feedback. However, current methods often rely on static or offline critic models, which fail to adapt as the policy evolves. In on-policy RL, the agent’s trajectory distribution and error patterns shift over time, causing stationary critics to become stale and providing feedback of diminishing utility. To address this, we introduce ECHO (Evolving Critic for Hindsight-Guided Optimization), a framework that jointly optimizes the policy and critic through a synchronized co-evolutionary loop. ECHO utilizes a cascaded rollout mechanism where the critic generates multiple diagnoses for an initial trajectory, followed by policy refinement to enable group-structured advantage estimation. We address the challenge of learning plateaus via a saturation-aware gain shaping objective, which rewards the critic for inducing incremental improvements in high-performing trajectories. By employing synchronized dual-track GRPO updates, ECHO ensures the critic’s feedback stays synchronized with the evolving policy. Experimental results show that ECHO yields more stable training and higher long-horizon task success across open-world environments.

cs.CL

Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表