Planetary Geospatial Foundation Models: A New Paradigm for Global Public Health
Arbaaz Muslim, Aviv Slobodkin, Katherine Wheeler-Martin, Eric Zhou, John Brittain, Martin Frasch, Hamsa Subramaniam, Jacob Bien 等 38 位作者
AI 速览：提出并展示地理空间基础模型 PDFM 如何以可泛化的地点表征补充传统流行病学工作流，并在多国多任务案例中改善公共卫生监测。
The efficacy of traditional disease prediction is limited by spatial gaps and temporal lags, which impact the timing and targets of resource deployments. Outbreaks escalate undetected, chronic disease burdens are quantified years later, and at-risk populations in data-sparse regions remain unaddressed. Planetary geospatial foundation models complement existing epidemiological workflows to provide operational improvements, encoding multimodal search, mobility, and environmental signals into generalizable place representations. As illustrations of this complementarity, we present independent global health case studies of Google Earth AI's Population Dynamics Foundation Model (PDFM) -- a foundation model for geospatial inference -- across four domains (vaccine-preventable, communicable, noncommunicable, maternal mental health), five tasks (spatial extrapolation, interpolation/nowcasting, probabilistic forecasting, prospective forecasting, risk stratification), and four countries (USA, Canada, Mexico, and the Democratic Republic of the Congo). Across these case studies, PDFM addresses critical surveillance gaps across domains: improving US-Canada border MMR vaccination coverage predictions by capturing cross-border behavioral spillovers domestic models miss; nowcasting cardiovascular disease to accelerate data availability; enhancing short-term municipal Mexican dengue forecasts for timely outbreak vector control; improving forecasts of cholera hotspots; and adding a transferable signal to individual-level postpartum-depression risk prediction in US states the model had never seen, while not replacing individual socioeconomic data or closing demographic screening gaps. Together, these results showcase capabilities of geospatial foundation models for public health surveillance.
AI 速览：提出自主AI系统PPE，从自然语言查询出发自动完成多模态地理空间数据检索、融合与模型搜索，并在多个健康、风险与流行病预测任务上报告优于专家基线。
Addressing critical global challenges, from food security and disaster risk to disease outbreaks and socio-economic vulnerability, demands high-fidelity geospatial modeling. However, building predictive planetary models remains bottlenecked by a fragmented data ecosystem, requiring manual data retrieval, multimodal data curation and fusion along with iterative model selection. We present the Planetary Prediction Engine (PPE), an autonomous AI system that executes this end-to-end workflow directly from natural-language queries. PPE synthesizes multimodal datasets on the fly, retrieving spatiotemporally relevant covariates across open-web and Earth observation platforms (Data Commons, Google Earth Engine) and fusing them with geospatial foundation model embeddings (PDFM, AlphaEarth). Simultaneously, it searches over task-tailored model architecture families with automated overfitting guards. Across diverse tasks, geographies, and scientific domains, PPE consistently outperforms state-of-the-art or manually tuned expert baselines. For US spatial regression, PPE improves mean $R^2$ across 21 CDC health indicators (76.8% vs. 60.0%), FEMA national risk indices (64.9% vs. 60.0%), and the Social Vulnerability Index (66.2% vs. 58.6%). For spatial downscaling in data-scarce settings, PPE integrates localized proxies to double baseline accuracy in Nigerian food security indicators ($R^2$ of 66.1% vs. 31.5%). For epidemiological nowcasting of the 2026 DRC Bundibugyo Ebola outbreak, PPE achieves a Recall@10 of 83.3% (identifying 15 of 18 newly invaded health zones across five weekly forecasts), a +10.3 percentage-point improvement over the public state-of-the-art modeling (~73%). By combining autonomous multimodal planetary data discovery with targeted model optimization, PPE lowers the technical barrier to planetary-scale analytics, enabling rapid, customized, expert-level deployment.
Accelerating scientific discovery with Co-Scientist
Juraj Gottweis, Wei-Hung Weng, Alexander Daryin, Tao Tu, Petar Sirkovic, Artiom Myaskovsky, Grzegorz Glowaty, Felix Weissenberger 等 51 位作者
AI 速览：基于Gemini的多智能体系统Co-Scientist通过生成、批判和进化假设，在生物医学领域辅助科学家发现新知识。
Scientific discovery is driven by scientists generating novel hypotheses for complex problems that undergo rigorous experimental validation. To augment this process, we introduce Co-Scientist, a multi-agent AI system built on Gemini for structured scientific thinking and hypothesis generation. Co-Scientist aims to help scientists discover new original knowledge. Conditioned on their research objectives and prior scientific evidence, it formulates demonstrably novel research hypotheses for experimental verification. The system's design involves agents continuously generating, critiquing and refining hypotheses accelerated by scaling test-time compute. Key contributions include: (1) a multi-agent architecture with an asynchronous task execution framework for flexible compute scaling; (2) a tournament evolution process for self-improving hypotheses generation. Automated evaluations show continued benefits of test-time compute scaling, improving hypothesis quality over time. While general purpose, we focus the validation in three biomedical applications: drug repurposing, novel target discovery, and explaining mechanisms of anti-microbial resistance. Specifically, Co-Scientist helped identify new drug repurposing candidates and synergistic combination therapies for acute myeloid leukemia, which were validated through in vitro experiments. These real-world validations demonstrate the potential of Co-Scientist to accelerate scientific discovery and usher in an era of AI empowered scientists.
Towards Automating Scientific Review with Google's Paper Assistant Tool
Rajesh Jayaram, Drew Tyler, David Woodruff, Corinna Cortes, Yossi Matias, Vahab Mirrokni, Vincent Cohen-Addad
AI 速览：提出AI与人类在科学评审中协作的四级分类框架，并介绍用于深度科学评审与验证的智能体框架Paper Assistant Tool（PAT）。
Artificial intelligence is driving a revolution in scientific discovery, accelerating everything from hypothesis generation to mathematical theorem proving. However, this rapid acceleration is creating a systemic challenge: traditional human peer review cannot scale to match the influx of AI-assisted science. Ultimately, to resolve this tension, we must also deploy AI to accelerate the verification and review process itself. To frame the discussion around this transition, we propose a taxonomy consisting of four progressive levels of AI-human collaboration in scientific evaluation, and discuss various trade-offs involved with each. As a step toward this future, we introduce the Paper Assistant Tool (PAT), an agentic AI framework built for deep scientific review and verification. PAT ingests full scientific manuscripts and produces a comprehensive evaluation, checking theoretical results, validating experiments, suggesting improvements, and identifying potential flaws. By utilizing inference scaling techniques, PAT is able to identify deeper issues than a single model call alone, achieving a 34% improvement over zero-shot recall on mathematical errors in the SPOT benchmark. Pilot deployments of PAT as a pre-submission tool for authors at two major Computer Science conferences -- STOC and ICML -- demonstrate its ability to identify critical errors and suggest substantive improvements to research papers. By catching errors early, PAT eases the cognitive burden placed on referees, while preserving their control over the outcomes of the review process.
AI 速览：提出人口动态基础模型（PDFM），通过图神经网络融合多源地理数据生成嵌入，在27个地理空间任务上取得领先表现。
Supporting the health and well-being of dynamic populations around the world requires governmental agencies, organizations and researchers to understand and reason over complex relationships between human behavior and local contexts in order to identify high-risk groups and strategically allocate limited resources. Traditional approaches to these classes of problems often entail developing manually curated, task-specific features and models to represent human behavior and the natural and built environment, which can be challenging to adapt to new, or even, related tasks. To address this, we introduce a Population Dynamics Foundation Model (PDFM) that aims to capture the relationships between diverse data modalities and is applicable to a broad range of geospatial tasks. We first construct a geo-indexed dataset for postal codes and counties across the United States, capturing rich aggregated information on human behavior from maps, busyness, and aggregated search trends, and environmental factors such as weather and air quality. We then model this data and the complex relationships between locations using a graph neural network, producing embeddings that can be adapted to a wide range of downstream tasks using relatively simple models. We evaluate the effectiveness of our approach by benchmarking it on 27 downstream tasks spanning three distinct domains: health indicators, socioeconomic factors, and environmental measurements. The approach achieves state-of-the-art performance on all 27 geospatial interpolation tasks, and on 25 out of the 27 extrapolation and super-resolution tasks. We combined the PDFM with a state-of-the-art forecasting foundation model, TimesFM, to predict unemployment and poverty, achieving performance that surpasses fully supervised forecasting. The full set of embeddings and sample code are publicly available for researchers.
Peter Brodeur, Jacob M. Koshy, Anil Palepu, Khaled Saab, Ava Homiar, Roma Ruparel, Charles Wu, Ryutaro Tanno 等 48 位作者
Large language model (LLM)-based AI systems have shown promise for patient-facing diagnostic and management conversations in simulated settings. Translating these systems into clinical practice requires assessment in real-world workflows with rigorous safety oversight. We report a prospective, single-arm feasibility study of an LLM-based conversational AI, the Articulate Medical Intelligence Explorer (AMIE), conducting clinical history taking and presentation of potential diagnoses for patients to discuss with their provider at urgent care appointments at a leading academic medical center. 100 adult patients completed an AMIE text-chat interaction up to 5 days before their appointment. We sought to assess the conversational safety and quality, patient and clinician experience, and clinical reasoning capabilities compared to primary care providers (PCPs). Human safety supervisors monitored all patient-AMIE interactions in real time and did not need to intervene to stop any consultations based on pre-defined criteria. Patients reported high satisfaction and their attitudes towards AI improved after interacting with AMIE (p < 0.001). PCPs found AMIE's output useful with a positive impact on preparedness. AMIE's differential diagnosis (DDx) included the final diagnosis, per chart review 8 weeks post-encounter, in 90% of cases, with 75% top-3 accuracy. Blinded assessment of AMIE and PCP DDx and management (Mx) plans suggested similar overall DDx and Mx plan quality, without significant differences for DDx (p = 0.6) and appropriateness and safety of Mx (p = 0.1 and 1.0, respectively). PCPs outperformed AMIE in the practicality (p = 0.003) and cost effectiveness (p = 0.004) of Mx. While further research is needed, this study demonstrates the initial feasibility, safety, and user acceptance of conversational AI in a real-world setting, representing crucial steps towards clinical translation.
AI 速览：作者报告，经过恰当提示并配备合适工具后，现代LLM能为几乎任意提示稳健生成高质量定制界面，人类偏好显著超过标准markdown输出。
AI models excel at creating content, but typically render it with static, predefined interfaces. Specifically, the output of LLMs is often a markdown "wall of text". Generative UI is a long standing promise, where the model generates not just the content, but the interface itself. Until now, Generative UI was not possible in a robust fashion. We demonstrate that when properly prompted and equipped with the right set of tools, a modern LLM can robustly produce high quality custom UIs for virtually any prompt. When ignoring generation speed, results generated by our implementation are overwhelmingly preferred by humans over the standard LLM markdown output. In fact, while the results generated by our implementation are worse than those crafted by human experts, they are at least comparable in 50% of cases. We show that this ability for robust Generative UI is emergent, with substantial improvements from previous models. We also create and release PAGEN, a novel dataset of expert-crafted results to aid in evaluating Generative UI implementations, as well as the results of our system for future comparisons. Interactive examples can be seen at https://generativeui.github.io
Shreya Agrawal, Mohammed Alewi Hassen, Emmanuel Asiedu Brempong, Boris Babenko, Fred Zyda, Olivia Graham, Di Li, Samier Merchant 等 19 位作者
Precipitation nowcasting, which predicts rainfall up to a few hours ahead, is a critical tool for vulnerable communities in the Global South frequently exposed to intense, rapidly developing storms. Timely forecasts provide a crucial window to protect lives and livelihoods. Traditional numerical weather prediction (NWP) methods suffer from high latency, low spatial and temporal resolution, and significant gaps in accuracy across the world. Recent machine learning-based nowcasting methods, common in the Global North, cannot be extended to the Global South due to extremely sparse radar coverage. We present Global MetNet, an operational global machine learning nowcasting model. It leverages the Global Precipitation Mission's CORRA dataset, geostationary satellite data, and global NWP data to predict precipitation for the next 12 hours. The model operates at a high resolution of approximately 0.05° (~5km) spatially and 15 minutes temporally. Global MetNet significantly outperforms industry-standard hourly forecasts and achieves significantly higher skill, making forecasts useful over a much larger area of the world than previously available. Our model demonstrates better skill in data-sparse regions than even the best high-resolution NWP models achieve in the US. Validated using ground radar and satellite data, it shows significant improvements across key metrics like the critical success index and fractions skill score for all precipitation rates and lead times. Crucially, our model generates forecasts in under a minute, making it readily deployable for real-time applications. It is already deployed for millions of users on Google Search. This work represents a key step in reducing global disparities in forecast quality and integrating sparse, high-resolution satellite observations into weather forecasting.
Anil Palepu, Valentin Liévin, Wei-Hung Weng, Khaled Saab, David Stutz, Yong Cheng, Kavita Kulkarni, S. Sara Mahdavi 等 20 位作者
While large language models (LLMs) have shown promise in diagnostic dialogue, their capabilities for effective management reasoning - including disease progression, therapeutic response, and safe medication prescription - remain under-explored. We advance the previously demonstrated diagnostic capabilities of the Articulate Medical Intelligence Explorer (AMIE) through a new LLM-based agentic system optimised for clinical management and dialogue, incorporating reasoning over the evolution of disease and multiple patient visit encounters, response to therapy, and professional competence in medication prescription. To ground its reasoning in authoritative clinical knowledge, AMIE leverages Gemini's long-context capabilities, combining in-context retrieval with structured reasoning to align its output with relevant and up-to-date clinical practice guidelines and drug formularies. In a randomized, blinded virtual Objective Structured Clinical Examination (OSCE) study, AMIE was compared to 21 primary care physicians (PCPs) across 100 multi-visit case scenarios designed to reflect UK NICE Guidance and BMJ Best Practice guidelines. AMIE was non-inferior to PCPs in management reasoning as assessed by specialist physicians and scored better in both preciseness of treatments and investigations, and in its alignment with and grounding of management plans in clinical guidelines. To benchmark medication reasoning, we developed RxQA, a multiple-choice question benchmark derived from two national drug formularies (US, UK) and validated by board-certified pharmacists. While AMIE and PCPs both benefited from the ability to access external drug information, AMIE outperformed PCPs on higher difficulty questions. While further research would be needed before real-world translation, AMIE's strong performance across evaluations marks a significant step towards conversational AI as a tool in disease management.
Sebastien Baur, Zaid Nabulsi, Wei-Hung Weng, Jake Garrison, Louis Blankemeier, Sam Fishman, Christina Chen, Sujay Kakarmath 等 18 位作者
AI 速览：作者提出基于掩码自编码器、在3.13亿段两秒音频片段上自监督训练的健康声学表征模型 HeAR，并通过线性探针在33项健康声学任务上评估其嵌入质量。
Health acoustic sounds such as coughs and breaths are known to contain useful health signals with significant potential for monitoring health and disease, yet are underexplored in the medical machine learning community. The existing deep learning systems for health acoustics are often narrowly trained and evaluated on a single task, which is limited by data and may hinder generalization to other tasks. To mitigate these gaps, we develop HeAR, a scalable self-supervised learning-based deep learning system using masked autoencoders trained on a large dataset of 313 million two-second long audio clips. Through linear probes, we establish HeAR as a state-of-the-art health audio embedding model on a benchmark of 33 health acoustic tasks across 6 datasets. By introducing this work, we hope to enable and accelerate further health acoustics research.