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Distribution matching distillation (DMD) has emerged as a leading paradigm for distilling diffusion models into few-step students, where an auxiliary fake score model tracks the student's distribution and the discrepancy between the teacher and fake predictions drives the student toward the teacher. In multi-step distillation, although only the student's final output is delivered, existing methods train the fake model on intermediate states or across all denoising steps. Consequently, the student's update signal becomes entangled with intermediate distributions, which can distort the matching direction and remain nonzero even after the student's final outputs already match the teacher distribution. To resolve this mismatch, we propose Endpoint Distribution Matching Distillation (eDMD), which trains a single shared fake model exclusively on the student's final outputs and uses it to correct every denoising step. Our theoretical analysis proves that this endpoint reference guarantees that the distribution matching term vanishes if and only if the student's final output distribution matches the teacher's, regardless of intermediate distributions. Beyond the fake reference, we further strengthen teacher supervision through a precise teacher (PT) that replaces single-step guided predictions with short multi-step trajectories on the final noise interval, paired with a calibrated query density for intermediate steps. Experiments on SD3-Medium, FLUX.2-klein (4B and 9B), and Qwen-Image-2.1 demonstrate that eDMD consistently outperforms existing distribution matching methods for 4-step generation.

Language-guided UAV navigation has largely focused on long-horizon route planning, leaving short-range, object-relative flight maneuvers underexplored. To address this gap, we formulate Flying-on-a-Word (Flow), a task requiring a UAV to convert concise natural-language instruction, egocentric visual observation, and current state dynamics into continuous flight actions. Flow encompasses both primitive motion commands and complex object-interactive behaviors, assessing motion intent comprehension and spatial context grounding. To enable policy learning and closed-loop evaluation, we introduce UAV-Flow, a comprehensive dataset comprising 30,692 expert-piloted real-world trajectories across eight distinct motion categories, alongside 10,109 simulation trajectories in the UAV-Flow-Sim environment equipped with task-specific completion criteria. Furthermore, we develop FlowVLA, which undergoes imitation pretraining on mixed real-sim demonstrations and online post-training via Tail-Aware GRPO (TGRPO). By leveraging group reward distributions, TGRPO effectively reinforces high-reward action sequences. Evaluated on 273 held-out UAV-Flow-Sim episodes, pretrained FlowVLA achieves a mean success rate of 75.58%, outperforming the strongest baseline by 6.72 percentage points, which TGRPO post-training further elevates to 93.16% with superior sample efficiency. Physical UAV experiments demonstrate robust execution of object-relative commands in both indoor and outdoor real-world scenes. Together, Flow establishes a novel benchmark and learning framework for language-conditioned flight maneuvers.

Quantifying disease-associated renal tubular remodeling is challenging because tubular appearances are heterogeneous. We introduce TuMAP (Tubular Morphotype-Aware Pathomics), a pipeline combining (1) dual-view foundation-model representations and provisional morphotype annotation, (2) compositional and within-morphotype pathomics, and (3) patient-level statistical inference. From 456,158 tubules in 358 PAS-stained kidney biopsy slides, TuMAP identified eight image-based morphotypes, seven of which showed stable subsampling assignments. Across 219 patients in six diagnostic groups, diabetic nephropathy (DN) and tubulointerstitial nephritis/acute tubular injury (TIN/ATI) each differed from minimal change disease in seven morphotype proportions, while IgA nephropathy differed in six. DN showed reduced nuclear solidity and increased eccentricity across all eight morphotypes. Area-normalized nuclear density exposed additional within-morphotype differences. TuMAP provides a framework for separating changes in tubular morphotype composition from phenotypic differences within morphotypes.

We introduce Sage-Taiyi, a metacognition-inspired architecture that uses accumulated scientific understanding to guide what to investigate next and how to investigate it. Through explicit monitoring and control, the system revises its understanding of evidence, assumptions, and unresolved questions, then uses these assessments to adapt research targets and select reusable reasoning methods. On Taiyi-Bench, an AI co-scientist ideation benchmark comprising 265 tasks from 50 papers across ten disciplines, Sage-Taiyi ranks first on all eight metrics of historical rediscovery and open-ended ideation, achieving an Overall score of 54.0 compared with 47.9 for the strongest baseline, AI Scientist-v2. It also performs well on two external scientific ideation benchmarks. Five expert-guided collaborations further connect its proposals to experimental and computational validation across chemistry, materials science, and engineering. In chemistry, reaction-condition optimization raises the yield of cobalt-catalyzed carbonylation from trace amounts to 84% and photocatalytic allylic amination from 13% to 69%. These results support metacognitive regulation as an approach to scientific ideation and its progression toward practical validation.