Marikkar, Umar, Husain, Syed Sameed, Awais, Muhammad, Atito, Sara
Immunofluorescence (IF) images reveal detailed information about structures and functions at the subcellular level. However, unlike RGB images, IF datasets pose challenges for deep learning models due to their inconsistencies in channel count and configuration, stemming from varying staining protocols across laboratories and studies. Although existing approaches build channel-adaptive models for training, they do not perform evaluations across IF datasets with unseen channel configurations. To address this, we first introduce a biologically informed view of cellular image channels by grouping them into either context or concept, where we treat the context channels as a reference for the concept channels in the image. We leverage this view to propose Channel Conditioned Cell Representations (C3R), a framework that learns representations that transfers well to both in-distribution (ID) and out-of-distribution (OOD) datasets which contain same and different channel configurations, respectively. C3R is a two-fold framework comprising a channel-adaptive encoder architecture and a masked knowledge distillation training strategy, both built around the context-concept principle. We find that C3R outperforms existing benchmarks on both ID and OOD tasks, while yielding state-of-the-art results on frozen encoder evaluation on the CHAMMI benchmark. Our method opens a new pathway for cross-dataset generalization between IF datasets, with no need for retraining on unseen channel configurations.
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cs.CV
Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2026 · 正式发表
Nazarieh, Fatemeh, Feng, Zhenhua, Kanojia, Diptesh, Kittler, Josef, Awais, Muhammad
Generating realistic and expressive audio-driven talking avatars remains a central challenge in digital human synthesis. Existing methods often depend on intermediate representations such as pose estimations for natural body motion, which restricts flexibility and adds visual distortions. Moreover, most audio-driven approaches rely on discrete emotion classifiers or text labels to regulate facial expression, reducing complex affective dynamics to coarse categories such as happy, sad, or angry. Such categorical supervision fails to capture the continuous and fine-grained speech dynamics (rhythm, energy, intensity) resulting in limited synchronization and emotionally shallow motion. To overcome these limitations, we present SyncDreamer, a unified Diffusion Transformer framework that generates identity-preserving and emotionally expressive talking avatars from only a single image, speech audio, and text prompt.We propose a visual adapter with Attention Localization Loss to maintain identity fidelity, further incorporating an audio dynamics encoder for rhythm- and emotion-aware motion, and an RL-based Cross-Modal Prompt Enhancer grounding textual cues in visual context for fine-grained motion control. Extensive experiments on portrait and full-body benchmarks demonstrate state-of-the-art performance in realism, synchronization accuracy, and semantic controllability, establishing a scalable foundation for expressive digital avatars in interactive and creative applications.
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cs.CV
Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2026 · 正式发表