High-content multi-channel imaging, from Cell Painting assays to remote sensing, is central to modern scientific pipelines. Because these channels are highly heterogeneous and experimental configurations frequently evolve, a practical vision backbone must be fundamentally channel-agnostic. Current channel-adaptive vision transformers rely on global self-attention with learnable channel embeddings, which can be computed only for previously known channels. Attempts to overcome this limitation of new channels either discard the embeddings, losing channel identity, or process each channel independently, thereby eliminating critical cross-channel interactions. To address this, we introduce ChanSFormer, an efficient Vision Transformer that replaces rigid embeddings with disentangled spatial-channel attention and individual channel CLS tokens. This architecture natively preserves both distinct channel identities and cross-channel information flow. Furthermore, the individual channel class token design unlocks more informative feature representations for self-supervised learning and enables representation-based channel sampling while remaining channel-agnostic. We evaluate ChanSFormer on two biology multi-channel datasets, CHAMMI, JUMP-CP and a satellite dataset, So2Sat. Experimental results show that ChanSFormer outperforms state-of-the-art methods by 3.93%-4.27% on JUMP-CP in classification accuracy. It also demonstrates exceptional cross-dataset transferability under a self-supervised setting, outperforming previous methods by up to 2.72% in accuracy in the same classification tasks. Furthermore, the disentangled attention reduces the quadratic complexity of channel-by-spatial sequence length of the global attention baseline, thus improving throughput by 55%-313%. Code is available at https://github.com/cvlab-stonybrook/ChanSFormer.
Large-scale astronomical surveys define a heterogeneous, partially observed multi-survey learning setting: each object is observed by only a subset of surveys, while survey observations differ in resolutions, wavelength coverage, noise characteristics, and footprints. This setting gives rise to a natural machine learning problem: given observations of an object in some surveys, how to infer its appearance in other surveys. We formalize this as the problem of cross-survey modality imputation and introduce COSMIO, a multi-survey benchmark of aligned observations obtained by forward-rendered shared astrophysical scenes across LSST, Euclid, and Roman under survey-specific instrument characteristics. The benchmark enables systematic evaluation of imputation across source-target survey combinations and missing-survey patterns. We evaluate a broad range of machine learning methods for imputation, which reveal a clear domain gap: methods developed for existing imputation settings transfer poorly to the survey setting. We identify rare-event imputation as a central challenge. This regime arises in the early stages of new surveys, when rare but scientifically valuable phenomena may be available only from prior surveys. We use strong gravitational lensing, where light from a background galaxy is gravitationally deflected by a foreground galaxy, as a representative rare-event setting. We evaluate model performance on zero-shot imputation of gravitational lenses and on downstream scientific tasks using the imputed lens observations. On our constructed evaluation set of galaxy-galaxy strong lenses, performance degrades under rare-event distribution shift, and this degradation further propagates to the downstream lens-detection task. Code: https://github.com/fw-ic/COSMIO.
Gaze following aims to predict where a person is looking in a scene, by predicting the target location, or indicating that the target is located outside the image. Recent works detect the gaze target by training a heatmap regression task with a pixel-wise mean-square error (MSE) loss, while formulating the in/out prediction task as a binary classification task. This training formulation puts a strict, pixel-level constraint in higher resolution on the single annotation available in training, and does not consider annotation variance and the correlation between the two subtasks. To address these issues, we introduce the patch distribution prediction (PDP) method. We replace the in/out prediction branch in previous models with the PDP branch, by predicting a patch-level gaze distribution that also considers the outside cases. Experiments show that our model regularizes the MSE loss by predicting better heatmap distributions on images with larger annotation variances, meanwhile bridging the gap between the target prediction and in/out prediction subtasks, showing a significant improvement in performance on both subtasks on public gaze following datasets. Code is available at: https://github.com/qiaomu-miao/gazefollowing_pdp
Peter Zeng State University of New York at Stony Brook, Weiling Li, Amie J. Paige State University of New York at Stony Brook, Zhengxiang Wang State University of New York at Stony Brook, Panagiotis Kaliosis, Dimitris Samaras Stony Brook University, Gregory Zelinsky, Susan E. Brennan State University of New York at Stony Brook 等 9 位作者
For generative AI agents to partner effectively with human users, the ability to accurately predict human intent is critical. But this ability to collaborate remains limited by a critical deficit: an inability to model common ground. We present a referential communication experiment with a factorial design involving director-matcher pairs (human-human, human-AI, AI-human, and AI-AI) that interact with multiple turns in repeated rounds to match pictures of objects not associated with any obvious lexicalized labels. We show that LVLMs cannot interactively generate and resolve referring expressions in a way that enables smooth communication, a crucial skill that underlies human language use. We release our corpus of 356 dialogues (89 pairs over 4 rounds each) along with the online pipeline for data collection and the tools for analyzing accuracy, efficiency, and lexical overlap.
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cs.CL · cs.AI
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表