Foundation-model predictors of perturbation response are evaluated primarily by aggregate accuracy. Using their predictions to prioritize experiments requires assessing each prediction's reliability. We audit the state-transition (ST) decoder used in STATE across three encoders (SE-600M, scGPT, and Tahoe-x1) and four cell lines under CRISPRi. The decoder's first attention layer has a low-rank output. Projecting this output onto 4-32 fixed directions estimated from training activations preserves mean per-perturbation Pearson delta correlation (PDC). This low-rank attention bottleneck bounds the decoder's reliability by distance to training responses: PDC declines as the cosine distance from a perturbation's observed response to its nearest training response increases. We propose predicted-NN-distance, the cosine distance from a predicted response to its nearest training response, as a per-prediction confidence score. The score has a mean absolute Spearman correlation of 0.81 with PDC, close to the 0.88 obtained with the observed response. Thresholds calibrated on this score transfer across encoders and cell lines, and the score remains predictive of PDC for drug perturbations.
Haolin Chen, Deon Metelski, Leon Qi, Tao Xia, Joonyul Lee, Steve Brown, Kevin Riley, Frank Wang 等 33 位作者
End-to-end automation of realistic healthcare operations stresses three capabilities underrepresented in current benchmarks: policy density, decisions must be grounded in a large library of medical, insurance, and operational rules; Multi-role composition: a single task requires the agent to play multiple roles with handoffs; and multilateral interaction: intermediate workflow steps are multi-turn dialogs, such as peer-to-peer review and patient outreach. We introduce $χ$-Bench, a benchmark of long-horizon healthcare workflows across three domains: provider prior authorization, payer utilization management, and care management. Each task hands the agent a clinical case in a high-fidelity simulator of 20 healthcare apps exposed via 87 MCP tools, which it must drive to a terminal status through tool calls and writing the role's artifacts, guided by a 1,290+ document managed-care operations handbook skill. Across 30 agent harness/models configurations, the best agent resolves only 28.0% of tasks, no agent clears 20% on strict pass^3, and executing all tasks in a single session slumps the performance to 3.8%. These results raise the hypothesis that similar gaps are likely to surface in other policy-dense, role-composed, irreversible enterprise domains.