Alice Driessen, Emil Malmsten, Steffen Wolf, Bernd Illing, Isinsu Katircioglu, Adriano Martinelli, Rolf Stahel, Solange Peters 等 14 位作者
Spatial transcriptomics maps gene expression across tissue sections and, when integrated with whole slide images, jointly captures both morphological architecture and molecular activity to provide a rich, multimodal view of tissue biology. ML approaches combining spatial transcriptomics and WSIs typically learn a mapping from morphological features to molecular profiles via contrastive alignment or supervised fine-tuning of pathology foundation models. In both cases, transcriptomics serves as a training signal rather than a true input modality, leaving inference fundamentally image-driven. We propose an early-fusion vision transformer architecture in which transcript tokens are constructed at arbitrary spatial resolution, merged with image patch tokens, and jointly processed through a shared transformer stack for deep cross-modal interaction. Starting from a pretrained vision-only pathology foundation model, we train HistoTx by continuing self-supervised pretraining on paired image and spatial transcriptomics data and demonstrate that: 1) at inference with image only, performance remains on par with the baseline on most tasks while improving on tasks that inherently benefit from molecular knowledge, such as gene expression prediction; 2) when both modalities are available at inference, jointly providing image and transcript inputs outperforms either modality alone.
Zhengxi Lu, Jiabo Ye, Fei Tang Nankai University, Yongliang Shen Zhejiang University, Haiyang Xu, Ziwei Zheng Xi'an Jiaotong University, Weiming Lu Zhejiang University, Ming Yan Alibaba Group 等 11 位作者
GUI agents have demonstrated remarkable progress in automating complex user interface interactions. However, training such agents for long-horizon tasks remains challenging. Single-turn reinforcement learning conditions on expert histories during training but self-generated histories during deployment, causing distribution mismatch. Online multi-turn methods eliminate this gap via environment interaction but suffer from sparse rewards and prohibitive costs. We propose \underline{\textbf{E}}xperience-driven \underline{\textbf{M}}ulti-turn \underline{\textbf{P}}olicy \underline{\textbf{O}}ptimization (\textbf{EMPO}), which leverages expert trajectories as environment experiences for on-policy multi-turn training. The agent constructs self-generated history throughout rollouts; when actions match expert experiences, the trajectory provides valid state transitions, and a Patch Module recovers mismatched steps to maintain on-policy rollouts. EMPO further incorporates discounted future rewards and dual-level advantage estimation to capture long-horizon dependencies. We also propose \textbf{AndroidControl-Real}, an evaluation metric strongly correlated with real-world performance (R^2=0.934). With only 1K public trajectories as RL experiences, our method achieves substantial gains over the base model (e.g., +12.0% on AndroidWorld and +23.8% on AITW) and achieves competitive performance against strong baselines such as UI-TARS-7B and GPT-4o, demonstrating better generalization than prior single-turn RL approaches. Code available: https://anonymous.4open.science/r/UI-S1-0DAF.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Zhengxi Lu, Fei Tang Nankai University, Guangyi Liu, Jin Ma, Kaitao Song Apple, Xu Tan, Wenqi Zhang Zhejiang University, Weiming Lu Zhejiang University 等 11 位作者
MLLM-based GUI agents have demonstrated strong capabilities in complex user interface interaction tasks. However, long-horizon scenarios remain challenging, as these agents are burdened with tasks beyond their intrinsic capabilities, suffering from memory degradation, progress confusion, and math hallucination. To address these challenges, we present \textbf{UI-Copilot}, a collaborative framework where the GUI agent focuses on task execution while a lightweight copilot provides on-demand assistance for memory retrieval and numerical computation. We introduce memory decoupling to separate persistent observations from transient execution context, and train the policy agent to selectively invoke the copilot as Retriever or Calculator based on task demands. To enable effective tool invocation learning, we propose \underline{\textbf{T}}ool-\underline{\textbf{I}}ntegrated \underline{\textbf{P}}olicy \underline{\textbf{O}}ptimization (\textbf{TIPO}), which separately optimizes tool selection through single-turn prediction and task execution through on-policy multi-turn rollouts. Experimental results show that UI-Copilot-7B achieves state-of-the-art performance on challenging MemGUI-Bench, outperforming strong 7B-scale GUI agents such as GUI-Owl-7B and UI-TARS-1.5-7B. Moreover, UI-Copilot-7B delivers a 17.1% absolute improvement on AndroidWorld over the base Qwen model, highlighting UI-Copilot’s strong generalization to real-world GUI tasks. Code website: https://anonymous.4open.science/r/UI-Copilot-0535.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表