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首次观测 · 记录 #1CVF · CVPR 2026:cvf:34d7cfe0b1b1b617624a05315a7b06c9CVF · CVPR 2026

HyperST: Hierarchical Hyperbolic Learning for Spatial Transcriptomics Prediction

Zhang, Chen, An, Yilu, Chen, Ying, Li, Hao, Ling, Xitong, Liu, Lihao, He, Junjun, Lin, Yuxiang 等 10 位作者

原文摘要

Spatial Transcriptomics (ST) merges the benefits of pathology images and gene expression, linking molecular profiles with tissue structure to analyze spot-level function comprehensively. Predicting gene expression from histology images is a cost-effective alternative to expensive ST technologies. However, existing methods mainly focus on spot-level image-to-gene matching but fail to leverage the full hierarchical structure of ST data, especially on the gene expression side, leading to incomplete image-gene alignment. Moreover, a challenge arises from the inherent information asymmetry: gene expression profiles contain more molecular details that may lack salient visual correlates in histological images, demanding a sophisticated representation learning approach to bridge this modality gap. We propose HyperST, a framework for ST prediction that learns multi-level image-gene representations by modeling the data's inherent hierarchy within hyperbolic space, a natural geometric setting for such structures. First, we design Multi-Level Representation Extractors to capture both spot-level and niche-level representations from each modality, providing context-aware information beyond individual spot-level image-gene pairs. Second, a Hierarchical Hyperbolic Alignment module is introduced to unify these representations, performing spatial alignment while hierarchically structuring image and gene embeddings. This alignment strategy enriches the image representations with molecular semantics, significantly improving cross-modal prediction. HyperST achieves state-of-the-art performance on four public datasets from different tissues, paving the way for scalable and accurate spatial transcriptomics prediction.

cs.CV

Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2026 · 正式发表

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CVF · CVPR 2026 ↗PDF ↗
首次观测 · 记录 #1CVF · CVPR 2026:cvf:357e171f5771a6cc359a6a306e43b913CVF · CVPR 2026

Towards Efficient Medical Reasoning with Minimal Fine-Tuning Data

Zhuang, Xinlin, Tang, Feilong, Yang, Haolin, Liu, Xiwei, Hu, Ming, Li, Huifa, Xue, Haochen, He, Junjun 等 12 位作者

原文摘要

Supervised Fine-Tuning (SFT) of the language backbone plays a pivotal role in adapting Vision-Language Models (VLMs) to specialized domains such as medical reasoning. However, existing SFT practices often rely on unfiltered textual datasets that contain redundant and low-quality samples, leading to substantial computational costs and suboptimal performance in complex clinical scenarios. Although existing methods attempt to alleviate this problem by selecting data based on sample difficulty, defined by knowledge and reasoning complexity, they overlook each sample's optimization utility reflected in its gradient. Interestingly, we find that gradient-based influence alone favors easy-to-optimize samples that cause large parameter shifts but lack deep reasoning chains, while difficulty alone selects noisy or overly complex textual cases that fail to guide stable optimization. Based on this observation, we propose a data selection strategy, Difficulty-Influence Quadrant (DIQ), which prioritizes samples in the "high-difficulty-high-influence" quadrant to balance complex clinical reasoning with substantial gradient influence. This enables efficient medical reasoning for VLMs with minimal fine-tuning data. Furthermore, Human and LLM-as-a-judge evaluations show that DIQ-selected subsets demonstrate higher data quality and generate clinical reasoning that is more aligned with expert practices in differential diagnosis, safety check, and evidence citation, as DIQ emphasizes samples that foster expert-like reasoning patterns. Extensive experiments on medical reasoning benchmarks demonstrate that DIQ enables VLM backbones fine-tuned on only 1% of selected data to match full-dataset performance, while using 10% consistently outperforms baseline methods, highlighting the superiority of principled data selection over brute-force scaling. The code is available at https://github.com/mihara-bot/DIQ.

cs.CV · cs.CL

Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2026 · 正式发表

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CVF · CVPR 2026 ↗PDF ↗
首次观测 · 记录 #1CVF · CVPR 2026:cvf:4acf31655495d1a74cc2c58b3de44518CVF · CVPR 2026

dMLLM-TTS: Self-Verified and Efficient Test-Time Scaling for Diffusion Multi-Modal Large Language Models

Xin, Yi, Luo, Siqi, Xu, Tianxiang, Qin, Qi, Chen, Haoxing, Zhu, Kaiwen, Zhang, Zhiwei, He, Yangfan 等 16 位作者

原文摘要

Diffusion Multi-modal Large Language Models (dMLLMs) have recently emerged as a novel architecture unifying image generation and understanding. However, developing effective and efficient Test-Time Scaling (TTS) methods to unlock their full generative potential remains an underexplored challenge. To address this, we propose dMLLM-TTS, a novel framework operating on two complementary scaling axes: (1) trajectory exploration scaling to enhance the diversity of generated hypotheses, and (2) iterative refinement scaling for stable generation. Conventional TTS approaches typically perform linear search across these two dimensions, incurring substantial computational costs of O(NT) and requiring an external verifier for best-of-N selection. To overcome these limitations, we propose two innovations. First, we design an efficient hierarchical search algorithm with O(N+T) complexity that adaptively expands and prunes sampling trajectories. Second, we introduce a self-verified feedback mechanism that leverages the dMLLMs' intrinsic image understanding capabilities to assess text-image alignment, eliminating the need for external verifier. Extensive experiments on the GenEval benchmark across three representative dMLLMs (e.g., Lumina-DiMOO, MMaDA, Muddit) show that our framework substantially improves generation quality while achieving up to 6x greater efficiency than linear search.

cs.CV · cs.CL

Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2026 · 正式发表

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CVF · CVPR 2026 ↗PDF ↗
首次观测 · 记录 #1CVF · CVPR 2026:cvf:d4d11f36c005d515fb96cf4dd03a1086CVF · CVPR 2026

EvoGraph-R1: Self-Evolving Multimodal Knowledge Hypergraphs for Agentic Retrieval

Lin, Jiashi, Jiang, Changhong, Lin, Xiangru, Zhang, Ruifei, Zhu, Xinyi, Liu, Jiyao, Tang, Cheng, Du, Ye 等 15 位作者

原文摘要

Retrieval-augmented generation (RAG) has emerged as a critical paradigm for grounding Multimodal Large Language Models (MLLMs) in external knowledge. Recent GraphRAG methods introduce structured entity-relation graphs to improve retrieval and reasoning. However, they remain limited by treating knowledge graphs as static data structures built offline and queried in a single pass. This static paradigm misaligns with the interactive, iterative nature of knowledge-intensive reasoning, creating three bottlenecks: (i) text-centric fragmentation that impedes cross-modal reasoning, (ii) frozen structures unable to incorporate new evidence or correct errors, and (iii) rigid single-pass retrieval without adaptive refinement. To overcome these limitations, we introduce EvoGraph-R1, a self-evolving GraphRAG framework that reconceptualizes knowledge graphs as dynamic environments shaped through agent interactions.We formulate retrieval as a Markov Decision Process (MDP) where the agent observes the graph state and executes actions to query (GraphRetrieve), expand (WebSearch), refine (GraphEdit), or terminate (Answer) the reasoning. These actions reshape the hypergraph structure and generate feedback signals that guide subsequent evolution.Through this closed loop, the hypergraph evolves by integrating new evidence, correcting errors, and refining structure to support multi-hop reasoning. Experiments on multimodal VQA and text QA benchmarks demonstrate substantial improvements over existing RAG baselines in accuracy, coverage, and traceability, establishing self-evolving knowledge graphs as a fundamental paradigm across modalities.

cs.CV · cs.CL · cs.AI

Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition · 2026 · 正式发表

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CVF · CVPR 2026 ↗PDF ↗