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A Scientific Claim Stability Framework for Evaluating MRI Morphometry Pipelines

Duy-Cat Can, Dang-Duat Tran, Anh-Khang Nguyen, Quoc-Bao Tran, Trung-Hieu Do, Van-Tu Nguyen, Duy-Thanh Vu, Oliver Y. Chén 等 9 位作者

MRI morphometry pipelines are often evaluated by measurement agreement or downstream accuracy, yet their scientific value depends on the conclusions they support. Two pipelines can produce similar feature-level results yet support different conclusions about aging, cognitive decline, or neurodegeneration. We introduce Scientific Claim Stability (SCS), a claim-centric evaluation framework that converts region-of-interest (ROI) morphometry tables into auditable claim cards and evaluates their support under changes in dataset, processing pipeline, atlas, feature family, and target. Across 10,370 MRI scans from three datasets and five cohorts, SCS generates 2,783 claim cards and evaluates 89 claim-family pairs. The evaluation distinguishes stable, transferable, and fragile claims. FreeSurfer 8-FastSurfer comparisons show high evidence concordance and low anatomical-support overlap under the primary covariate specification. Acquisition-adjusted analyses show that the magnitude of support disagreement depends on the model specification. Structured review by specialists in geriatrics, neuroscience, and radiology, alongside auxiliary ChatGPT and Gemini reviewers, assesses claim plausibility, clarity, faithfulness, usefulness, and caution. SCS provides a reproducible way to audit the evidential stability of morphometry claims without assuming a universal gold standard.

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HOPE: Hybrid Optimized Parallel Encoding with Supervised and Unsupervised Semantic Fusion for Depression Symptom Detection

Tu-Phuong Mai Vietnam National University Hanoi, Minh-Ha H. Le, Duc-Luong Tran, Phuong-Anh Chu, Duy-Cat Can Université de Lausanne, Centre hospitalier universitaire vaudois (CHUV) and VNU University of Engineering and Technology, Hoang-Quynh Le

Timely detection of depression symptoms is essential for early intervention, and the continuous stream of user-generated content on social media provides an ideal source for this purpose. To address this challenge, we propose HOPE, a Hybrid Optimized Parallel Encoding framework that combines supervised symptom relevance signals with unsupervised intrinsic semantic clustering. This parallel design enables robust symptom detection under limited labeled data and introduces a distinctive semantic-similarity perspective with automatic class-anchor adjustment. We also propose an optimized hybrid semantic fusion mechanism to combine supervised and unsupervised scores through a learnable module. We evaluate our system on multiple benchmark datasets and surpass previous approaches, demonstrating its effectiveness in detecting fine-grained symptoms and early warning of mental health risk. Source code is available at https://github.com/candleMind/hope.

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Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表