Yuqi Jia, Yunjie Tian, Jiayu Zheng, Yijun Liang, Jingchen Sun, Mengyu Zhao, Di Fu
We introduce Axion 1.0, a fully open agent foundation model that combines strong and broad agentic capabilities with a remarkably simple training recipe. Axion 1.0 is trained in only three stages: two lightweight supervised fine-tuning stages followed by reinforcement learning, without dedicated mid-training, direct preference optimization (DPO), or on-policy distillation (OPD). The first SFT stage develops strong self-contained reasoning through model-aware data construction, where we synthesize challenging problems and adversarially strengthen them based on the base model's own successful solution strategies. The second stage extends these capabilities to tool-dependent reasoning through a scalable pipeline for constructing diverse and automatically verifiable tasks grounded in real-world data sources and deterministic computation. Finally, reinforcement learning further strengthens long-horizon reasoning and interaction with external tools and environments. Despite this compact training recipe, Axion 1.0 achieves strong performance across a broad suite of agentic benchmarks and is competitive with leading commercial models on several of them. Equally importantly, Axion 1.0 is open beyond model weights: we release the complete recipe, including data construction, generation, filtering, verification, prompts, and training code, enabling the entire development process to be reproduced and extended. Axion 1.0 demonstrates that strong agent foundation models can be both open and simple, offering a practical and reproducible path toward advancing open agentic intelligence.
Xing Liu, Yifan Guo, Hongtai Lv, Lei Lou, Yuyi Tan, Jiang Du, Xijia Zhang, Ming Zhang 等 21 位作者
Intraoperative frozen-section diagnosis of central nervous system (CNS) lesions guides surgical decisions but is challenged by artefacts, diagnostic complexity and time constraints. Most pathology foundation models have limited exposure to CNS frozen tissue. Here we present FOCUS, a subspecialty foundation model pretrained on 27,930 frozen-section whole-slide images enriched for CNS tissue. FOCUS ranked first across all 11 diagnostic and 12 biomarker-prediction tasks in the internal test cohort, achieving mean AUCs of 0.969 and 0.877, respectively. This advantage was retained in the temporal and external test cohorts. We further organized a WHO-aligned diagnostic hierarchy, where FOCUS also outperformed comparator models. In a reader study, FOCUS assistance enabled junior readers to approach or exceed unassisted senior readers in hierarchical diagnostic accuracy and granularity. More importantly, FOCUS assistance enabled readers to correctly identify a mean of 63.0% of initially missed lymphoma cases (73.2% among junior readers), potentially avoiding unnecessary extensive resection. These findings highlight the potential of FOCUS to provide clinically actionable support for intraoperative CNS pathology and inform surgical decisions.