Xiangyu Li, Jincheng Li, Xing Xie, Bin Guan, Shaohua Kevin Zhou, Rui Yan, Ran Su
Whole-slide multiple instance learning can predict diagnostic and prognostic labels from tissue composition while making limited use of spatial organization. Providing coordinates or a graph does not establish that a trained predictor uses tissue neighborhoods. We examine this gap as spatial blindness and hypothesize that early composition learning can weaken supervision of a spatial pathway. We introduce ResTopoMIL, which freezes a learned composition predictor before training a graph residual with a coordinate-reassignment separation loss. Permutation and information analyses distinguish architectural symmetry, available spatial information and the proposed optimization mechanism. On a controlled spatial task, staged training achieved an AUC of 0.987, compared with 0.684 for the same jointly trained architecture. Performance remained high on a composition-only task. Across four WSI classification and five survival benchmarks, ResTopoMIL improved mean primary performance on eight tasks; four improvements remained significant after Holm-adjusted patient-cluster tests. Coordinate-free residual controls recovered some of the gains, while neighborhood destruction reduced performance close to the composition anchor. Neighborhood-preserving transformations and anatomy-stratified perturbations further characterized this dependence. These results support fixing a composition reference as a practical intervention for learning spatial corrections, while retaining additional appearance capacity as a contributing explanation.
Xiangyu Li, Jincheng Li, Tianle Du, Yanheng Li, Haoxuan Che, Yuxin Sun, Long Bai, Liangliang Liu 等 9 位作者
A question about a whole-slide image rarely names every morphological finding needed to answer it. Question-guided patch selection can therefore overlook supporting morphology, while slide-level compression can dilute focal evidence. Inspired by how pathologists combine broad slide review, question-directed examination, and integration of their findings, we introduce BEYONDPATH, a Preserve-Focus-Fuse framework for whole-slide image question answering. Preserve learns a question-agnostic Morphology Bank through answer supervision across multiple questions about each training slide. Focus retrieves questionspecific evidence from all foreground patches, including regions outside the Bank. Fuse integrates the preserved morphology at the retrieved evidence positions through Morphology-on-Visual-Evidence Fusion, producing a fixed 96-token visual prefix. On WSI-Bench, BEYONDPATH achieves an Avg-9 of 0.769 and leads all eight reported report-generation metrics using the same checkpoint. It also achieves 0.639 zero-shot overall accuracy on SlideBench-BCNB. Controlled ablations show complementary benefits from morphology preservation and question-directed retrieval, and support cross-question supervision and fusion at the evidence positions. These results support looking beyond the question's explicit cues: preserving broader slide morphology while retaining the ability to seek evidence for each question.
Jincheng Liu, Sijun He Tencent, Jingjing Wu, Xiangsen Wang, Yang Chen, Zhaoqi Kuang, Siqi Bao, Yuan Yao
Recent large language models (LLMs) have shown strong reasoning capabilities. However, a critical question remains: do these models possess genuine strategic reasoning, or do they primarily excel at pattern recognition? To address this, we present ChessArena, a chess-based testbed for evaluating LLMs. Chess demands strategic reasoning, precise rule adherence, and the ability to track complex game states. ChessArena is a competitive framework where LLMs play against each other under four play modes. We evaluate 13 LLMs across over 800 games, testing basic understanding, move selection, and puzzle solving. Results reveal significant shortcomings: no model beats Maia-1100 (human amateur level), and some lose to random play. We also present a strong baseline: our fine-tuned Qwen3-8B substantially improves performance, approaching much larger state-of-the-art reasoning models.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表