Paul S. Scotti, Mihir Tripathy, Cesar Kadir Torrico Villanueva, Reese Kneeland, Tong Chen, Ashutosh Narang, Charan Santhirasegaran, Jonathan Xu 等 11 位作者
Reconstructions of visual perception from brain activity have improved tremendously, but the practical utility of such methods has been limited. This is because such models are trained independently per subject where each subject requires dozens of hours of expensive fMRI training data to attain high-quality results. The present work showcases high-quality reconstructions using only 1 hour of fMRI training data. We pretrain our model across 7 subjects and then fine-tune on minimal data from a new subject. Our novel functional alignment procedure linearly maps all brain data to a shared-subject latent space, followed by a shared non-linear mapping to CLIP image space. We then map from CLIP space to pixel space by fine-tuning Stable Diffusion XL to accept CLIP latents as inputs instead of text. This approach improves out-of-subject generalization with limited training data and also attains state-of-the-art image retrieval and reconstruction metrics compared to single-subject approaches. MindEye2 demonstrates how accurate reconstructions of perception are possible from a single visit to the MRI facility. All code is available on GitHub.
Sheng Wang, Jialu Yao, Maria V. Rossi, Shunsuke Koga, Esther Baranov, MacLean P. Nasrallah, Songhao Li, Jonathan Xu 等 25 位作者
Medical AI learns from the answers doctors record, but rarely from how they interpret the evidence to reach them. Here we introduce PathCowork, a framework that turns pathologists' narrated examinations into supervision for visual grounding and procedures that guide diagnostic AI agents. Synchronized gaze, narration and navigation link visual findings to the process of interpreting them. Across 48 sessions from 16 pathologists, the platform captured 1,028 minutes of slide review. Using these data, we trained PathCowork-1T for server deployment and PathCowork-27B for local deployment, with improved visual grounding. Across five organ-specific evaluations, agents combining this grounding with recorded diagnostic procedures achieved primary task scores averaging 17.9 and 24.1 percentage points higher than Claude Code and Codex, respectively, with shorter processing times and lower inference costs. Compared to the state-of-the-art multiple-instance learning AIs, the PathCowork agent-proposed regions achieved higher prostate-grading scores with limited slide labels. PathCowork can also help construct pathology AI benchmarks where questions derived from the recordings identified difficulties in recognizing viewing context and rejecting inapplicable premises. In summary, PathCowork proposes a new paradigm to scale up the data collection and train pathology AI through transparent reasoning from diagnostic sessions, opening a path towards systems that learn directly from routine clinical practice.