Long-term time-series forecasting supports decisions in energy, transportation, and other applications where reliable predictions are needed beyond the observed data. Although forecasting research has advanced model architectures, fixed activation configurations provide limited guidance on how activation choices should vary across datasets and prediction horizons. This study aims to establish when task-specific activation choices improve forecasting accuracy and how previous experiments can guide the selection of suitable configurations for new tasks. We develop a calibrated selection policy that learns a reliable default from prior experiments, adapts the activation function and its location to each task, and retains the default when evidence for a change is insufficient. In an evaluation supported by 1,225 Informer training runs across 17 dataset variants and 51 forecasting tasks, the policy reduces mean squared error by 7.86% on average relative to the conventional fixed-activation baseline and improves 72.55% of tasks. These findings establish activation choice and placement as practical opportunities for improving existing forecasting models and show how accumulated experimental evidence can guide configuration decisions without repeating an exhaustive search for every task.
Multiple instance learning (MIL) is the dominant framework for whole-slide image analysis in computational pathology, typically combining a frozen patch encoder, a projection layer, and a slide-level aggregator. While encoders and aggregators have been extensively studied, the projection layer remains a largely morphology-only bottleneck. This limits endpoints such as biomarker status and survival, which are governed by a molecular state that is not fully captured by H&E morphology. We introduce Molecularly Informed Staining Transform (MIST), a plug-in replacement for the MIL projection layer that uses paired spatial transcriptomics only during training to construct virtual molecular stains. MIST clusters gene expression profiles into cross-modal prototypes, anchors them in the frozen foundation model feature space, and uses them to reorganize H&E patch features along molecularly guided axes. It requires no transcriptomics at inference and can be inserted before standard MIL aggregators. We evaluate MIST across 23 downstream tasks and 8 MIL aggregators. MIST improves 240 of 256 configurations over the standard projection layer, with an average gain of +3.5%, observed consistently across endpoint types: +5.2% on survival prediction, +3.3% on tissue subtyping, and +2.6% on biomarker prediction. Ablations confirm that gene-derived prototypes are the primary source of the gains, while spatial, biological, and pathological analyses show that cross-modal prototype affinities capture spatially coherent molecular programs from H&E alone.
Zhihui Chen, Kai He National University of Singapore, Qingyuan Lei, Bin Pu, Jian Zhang, Yuling Xu, Mengling Feng National University of Singapore
Text-guided image editors can now manipulate authentic medical scans with high fidelity, enabling lesion implantation/removal that threatens clinical trust and safety. Existing defenses are inadequate for healthcare. Medical detectors are largely black-box, while MLLM-based explainers are typically post-hoc, lack medical expertise, and may hallucinate evidence on ambiguous cases. We present MedForge, a data-and-method solution for pre-hoc, evidence-grounded medical forgery detection. We introduce MedForge-90K, a large-scale benchmark of realistic lesion edits across 19 pathologies with expert-guided reasoning supervision via doctor inspection guidelines and gold edit locations. Building on it, MedForge-Reasoner performs localize-then-analyze reasoning, predicting suspicious regions before producing a verdict, and is further aligned with Forgery-aware GSPO to strengthen grounding and reduce hallucinations. Experiments demonstrate state-of-the-art detection accuracy and trustworthy, expert-aligned explanations.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表