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原文摘要

Brachytherapy is a complex radiation oncology problem that requires the simultaneous prediction of radiation dose, which is used for treatment planning, and a set of machine parameters, known as dwell times, used for treatment delivery. We propose Direct Dwell Time Transformer (D2T2), the first deep learning architecture that directly predicts dwell times during dose prediction. D2T2 is a two stage model, where the first stage predicts a vector of dwell times and the second implements the physical model of radiation delivery, namely a linear combination of radiation dose kernels. Besides the automatic prediction of dwell times, this has the benefit of constraining the model to make physically plausible dose predictions, when trained end-to-end. To enhance this training, we also propose a new loss function, denoted as the gamma loss, based on the prediction of the gamma index, which is the gold standard of dose comparisons. This is implemented by training a model to predict the latter using a synthetic dataset of groundtruth and predicted dose pairs. We train D2T2 on a large dataset of ~5,000 clinical brachytherapy plans---the largest such dataset to date---spanning gynecological, breast, and other treatment sites. Results demonstrate that D2T2 outperforms existing methods in both accuracy and speed. Notably, D2T2 produces deliverable plans and physically valid dose distributions in a single forward pass, for any application of brachytherapy, hours faster than manual planning and minutes faster than more recent automated methods.