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新论文 · v1arXiv:2611.11349

AOP-Smart-Finder: A High-Throughput Human-AI Hybrid Framework for AOP Discovery and Evidence Mapping from Large-Scale Literature

Qinjiang Niu, Lu Yan

原文摘要

The rapid growth of scientific literature and the high heterogeneity of biological terminology and mechanistic descriptions make it difficult for researchers to integrate scattered research evidence, identify connections among biological events, and construct mechanistic networks. Here, we developed a high-throughput human-AI hybrid framework, AOP-Smart-Finder, for biological event discovery, relationship mining, and Adverse Outcome Pathway (AOP) construction and evidence mapping from large-scale literature. This framework integrates Large Language Models (LLMs), AOP-Smart retrieval-augmented generation (RAG) technology, and Python-based automation, supporting two analysis modes: one based on a single compound and the other based on a predefined set of biological events. In the di(2-ethylhexyl) phthalate (DEHP) case, the system processed 12,983 articles within 30 min and included 1,093 of them, from which it extracted 1,589 biological events (including 458 official key events [KEs] and 1,131 candidate KEs) and 2,519 key event relationships (KERs). In the amyotrophic lateral sclerosis (ALS) case, the system identified 55 stressors from 437 articles and extracted 278 biological events and 548 event relationships. Following manual curation and Weight of Evidence (WoE) evaluation, a mechanistic network comprising 16 KEs and 23 KERs was ultimately constructed. This framework can either use existing AOPs as knowledge guidance for mechanistic expansion and evidence supplementation, or discover novel event connections and construct mechanistic networks around user-specified research topics. It provides a high-throughput, traceable, human-AI hybrid methodology for complex biological mechanism elucidation and AOP discovery driven by large-scale literature.

cs.CL · q-bio.QM

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arXiv ↗PDF ↗
新论文 · v1arXiv:2610.35434

Skill$^{\infty}$: Recursive Self-Improvement for Agent Skill Optimization

Wangcheng Tao, Zhanglu Yan, Han Wu, Weng-Fai Wong

原文摘要

Recursive self-improvement (RSI), in which a system also improves the way it improves, is a long-standing aspiration on the path to AGI. Language agents increasingly store procedural knowledge in reusable skills. Optimizing skills offers a direct way to achieve RSI, because the optimization procedure itself can be encoded as a skill. Existing skill optimizers, however, follow a hand-designed procedure. Even methods that evolve a meta-skill confine it to a fixed pipeline and relearn it for each task. We present Skill$^{\infty}$, which makes skill optimization recursively self-improving: a meta agent follows a meta-skill to optimize task skills and optimizes the meta-skill itself using the same procedure. The optimization is agent-led. The meta agent diagnoses execution traces, proposes candidates, requests independent reviews, and allocates the search budget. The meta-skill defines these steps, allowing self-improvement to rewrite them. This meta-skill is also decoupled from task skills, refined on multiple skill optimization tasks and then reused to optimize task skills across diverse domains. As in deployment, skills at both levels are standard packages loaded through native skill discovery. On 83 SkillsBench tasks, Skill$^{\infty}$ reaches a pass rate of 60.7%, compared with 56.4% for human-curated skills and 54.5% for SkillEvolver.

cs.AI · cs.CL

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arXiv ↗PDF ↗
首次观测 · 记录 #1ACL Anthology · ACL 2026:acl:2026.acl-long.866ACL Anthology · ACL 2026

SEE: Signal Embedding Energy for Quantifying Noise Interference in Large Audio Language Models

Yuanhe Zhang, Jiayu Tian, Yibo Zhang Beijing University of Posts and Telecommunications, Shilinlu Yan, Liang Lin, Zhenhong Zhou, Li Sun Beijing University of Post and Telecommunications, Sen Su Beijing University of Posts and Telecommunications

原文摘要

Large Audio Language Models (LALMs) have been widely applied in real-time scenarios, such as in-car assistants and online meeting comprehension. In practice, audio inputs are often corrupted by device and environmental noise, leading to performance degradation. However, existing LALM studies on noise lack quantitative analysis and rely mainly on intuition and empirical observation, thus failing to understand practical robustness. To address this issue, we introduce Signal Embedding Energy (SEE), a method for quantifying the impact of noise intensity on LALM inputs, enabling the differentiation of LALM robustness in real-world deployments. SEE introduces a perspective based on structured activation subspaces derived from the model’s internal representations, which more accurately captures its perception of noise than raw audio features. Across experiments, SEE exhibits a strong correlation with LALM performance, achieving a correlation of 0.98. Surprisingly, traditional audio denoising methods are only marginally effective for LALMs, and, in some cases, even increase SEE and impair performance. This suggests a mismatch between speech-centric denoising objectives and the noise sensitivity of modern LALMs. Therefore, we propose a mitigation strategy derived from SEE to denoise LALM inputs, outperforming existing denoising methods. This paper introduces a novel metric for noise quantification in LALMs, providing guidance for robustness improvements in real-world deployments.

cs.CL

Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表

版本更新 · v4arXiv:2507.05201Google Research

MedGemma Technical Report

Andrew Sellergren, Sahar Kazemzadeh, Tiam Jaroensri, Atilla Kiraly, Madeleine Traverse, Timo Kohlberger, Shawn Xu, Fayaz Jamil 等 81 位作者

原文摘要

Artificial intelligence (AI) has significant potential in healthcare applications, but its training and deployment faces challenges due to healthcare's diverse data, complex tasks, and the need to preserve privacy. Foundation models that perform well on medical tasks and require less task-specific tuning data are critical to accelerate the development of healthcare AI applications. We introduce MedGemma, a collection of medical vision-language foundation models based on Gemma 3 4B and 27B. MedGemma demonstrates advanced medical understanding and reasoning on images and text, significantly exceeding the performance of similar-sized generative models and approaching the performance of task-specific models, while maintaining the general capabilities of the Gemma 3 base models. For out-of-distribution tasks, MedGemma achieves 2.6-10% improvement on medical multimodal question answering, 15.5-18.1% improvement on chest X-ray finding classification, and 10.8% improvement on agentic evaluations compared to the base models. Fine-tuning MedGemma further improves performance in subdomains, reducing errors in electronic health record information retrieval by 50% and reaching comparable performance to existing specialized state-of-the-art methods for pneumothorax classification and histopathology patch classification. We additionally introduce MedSigLIP, a medically-tuned vision encoder derived from SigLIP. MedSigLIP powers the visual understanding capabilities of MedGemma and as an encoder achieves comparable or better performance than specialized medical image encoders. Taken together, the MedGemma collection provides a strong foundation of medical image and text capabilities, with potential to significantly accelerate medical research and development of downstream applications. The MedGemma collection, including tutorials and model weights, can be found at https://goo.gle/medgemma.

cs.AI · cs.CL · cs.CV

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arXiv ↗PDF ↗