Marcel Müller, Mohammad Ghazi Vakili, Yoshihiro Ogura, Ella Ashoori, Shimeng Wang, Alessandro S. Nascimento, Eddie Calleja, Yutong Zhao 等 16 位作者
Computational drug discovery offers a growing range of tools for proposing and evaluating molecules, but combining them and deciding what to do next still requires substantial expert effort. Here, we introduce El Agente Fármaco, an AI scientist that uses modern large language model (LLM) technology to turn discovery goals expressed in everyday language into complex, scalable computational screening workflows. The agentic harness selects scientific tools, reviews their results, and adjusts subsequent steps to the target and the user's objectives. Our approach centers on a shared scientific memory: Fármaco Atlas, which stores molecules, structures, and results together with their provenance -- a record of how they were obtained. The agent uses targeted database queries to retrieve the evidence needed for each decision. A single request can launch calculations for an entire collection of molecules, without requiring a separate LLM decision for every compound. This design limits the information the model must process as screening collections grow, while keeping the underlying results available for inspection and further analysis. The integrated tools support molecule generation, prediction of binding and molecular properties, and searches for compounds available for purchase. In a retrospective comparison with an expert-led campaign, the agent proposed chemically distinct candidates with competitive docking scores and higher calculated drug-likeness under explicitly imposed selection criteria. In a 22-task benchmark against plain tool calls and Codex, the agent achieved the highest observed mean model-judged score, with lower median cumulative token use and peak context. Fármaco provides a foundation for flexible, scalable drug discovery workflows that connect scientific reasoning with an enduring, traceable record of computational work.
Source-only domain generalization (DG) for remote sensing semantic segmentation seeks reliable predictions in unseen domains without target-domain data during training. Although vision foundation models offer transferable knowledge, category recognition remains sensitive to source-specific visual cues, while task-specific adaptation may weaken pretrained transferability. We propose ASCoR, an asymmetric semantic-spatial framework built on SAM3. Its text-conditioned semantic branch uses class-name prompts to provide explicit category guidance. Probe-Once Dynamic Adaptive LoRA distributes a fixed adaptation budget across encoder blocks to limit source-specific specialization. A complementary task-specific dense branch learns multi-scale spatial representations using a separate frozen SAM3 image encoder. A lightweight reliability router integrates the two branches through bounded spatial correction based on local prediction reliability. All components are trained using source-domain supervision only. Experiments on the ISPRS, LoveDA, and OpenEarthMap benchmarks cover nine cross-domain transfers. ASCoR achieves a state-of-the-art mean IoU of 68.61% across six ISPRS transfers, outperforming the previous best method by 2.69 percentage points. It also achieves the best results on all three LoveDA/OpenEarthMap transfers, with 59.07%, 47.95%, and 49.38% mIoU on Rural-to-Urban, Urban-to-Rural, and Urban-to-OpenEarthMap, respectively. Ablation studies, feature visualizations, and spatial reliability analyses support the effectiveness and complementarity of the proposed components. Code: https://github.com/WangZitong42/ASCoR.
Jiangmeng Li, Jinglin Xu, Yi Li, Yumeng Liu, Jiahuan Zhou, Fanjiang Xu, Hui Xiong, Gang Hua
Multimodal test-time adaptation (TTA) enables pretrained multimodal models to accommodate distribution shifts during inference using only unlabeled test data, without recourse to the original training data. Compared with unimodal adaptation, multimodal adaptation is further complicated by the coexistence and interaction of multiple representation perspectives. This complexity is particularly pronounced under modality reliability shifts, which preserve modality availability but degrade information quality, and modality availability shifts, which render the corresponding modality entirely inaccessible. Category-conditional Gaussian modeling offers a natural starting point for handling such distributional variations, having proven effective in unimodal test-time adaptation for characterizing representation distributions, yet its extension to multimodal settings requires a more elaborate formulation. To this end, we propose Adaptive Probabilistic Gaussian Calibration (AdaPGC), which extends category-conditional Gaussian modeling across modality-specific and multimodal fusion representations for probabilistic calibration under multimodal distribution shifts. AdaPGC continuously updates category-conditional Gaussian models over modality-specific and fusion representations, using the resulting probabilistic predictions to calibrate source model predictions and guide reliability based rectification, while exploiting their joint distributions to recover unavailable fusion representations. Extensive experiments under diverse modality corruption and missingness conditions demonstrate that AdaPGC effectively improves robustness under both modality reliability and availability shifts. Our source code will be released at https://github.com/XuJinglinn/AdaPGC-plus.
Xinyue Xu, Hongbin Lin, Juangui Xu, Hualiang Wang, Lehan Wang, Lijie Hu, Adrian Weller, Xiaomeng Li
Medical imaging modalities such as ultrasound and X-ray are widely used in clinical practice, where diagnosis follows a structured, evidence-driven workflow aligned with standardized criteria. While multimodal large language models (MLLMs) show promise for automated medical report generation, most existing systems rely on end-to-end multimodal fusion without modeling clinically defined intermediate attributes, leading to limited grounding and interpretability. To address this issue, we propose CORAL (COncept-grounded ReAsoning with Localization), a multimodal framework that integrates spatial grounding and concept-level supervision into a unified reasoning process. CORAL employs a prompt-driven medical segmentation model to localize lesions and predicts multi-class clinical attributes through a Concept Bottleneck module. The resulting textual concept tokens are combined with mask-modulated visual features within an MLLM to enable structured report generation and diagnostic prediction. Experiments on BUS-CoT and IU X-ray datasets demonstrate consistent improvements in diagnostic accuracy, concept consistency, and report quality over strong general-purpose and medical MLLMs, indicating that concept-grounded reasoning better aligns generation with clinical decision processes.
Mingxin Li, Enge Song, Yueshang Zuo, Xiaodong Liu, Rong Wen, Qiang Fu, Gianni Antichi, Jian He 等 30 位作者
LLM agents increasingly rely on tool calling to complete tasks. Model Context Protocol (MCP) standardizes tool calling between LLM agents and tool providers. It reduces integration cost and drives rapid growth in tool scale. In production deployments, tool access becomes difficult to scale. On the tool provider side, legacy services are not directly callable through MCP; the rapid protocol development creates ongoing compatibility cost. On the agent side, the number of mounted tools is limited by the LLM context window and inference overhead; mounting a large tool set increases token usage and inference latency and can reduce task success rate. Moreover, for stateful MCP backends with multiple replicas, preserving session affinity increases client-side complexity. We present a cloud-scale MCP Gateway system. It breaks the direct-connect model on the data plane and offloads legacy service integration, consolidating incompatible MCP variants, access control, tool recommendation, and session-aware routing at the gateway. The conversion module supports 315 OpenAPI services in the cloud and integrates MCP transport variants. Session-aware routing decouples the scalability of the gateway layer and the MCP service layer. The hybrid retrieval engine sustains $\sim$98\% Top-15 recall; it scales agent tool access to 3{,}000+ tools with improved tool selection accuracy. We also share the lessons learned from deploying the gateway system in production.
Coding agents can now rewrite repository-scale codebases while preserving tested behavior, creating a new challenge for plagiarism detection, license auditing, and software provenance. We ask whether such rewrites can still be traced to their source. Existing clone benchmarks emphasize fragments and bounded edits, while repository-transformation benchmarks evaluate functional correctness rather than provenance. Moreover, ranking the most similar source does not establish derivation when independent implementations can be similarly close. We define repository-level agentic code laundering and introduce Launder-Bench, to our knowledge the first repository-level benchmark for provenance under agentic rewriting, constructed from 282 real-world repositories. A source-hidden reconstruction protocol decomposes source behavior, reconstructs modules and repository structure, and retains rewrites only after execution-based verification. We evaluate the same provenance problem in two complementary settings: Launder-Bench-Pair contains 1,128 pairwise instances asking whether two repositories share provenance, while Launder-Bench-Attr contains 229 source-attribution instances asking which candidate is the source, with abstention when evidence is insufficient. Measured same-domain independent repositories establish how much similarity can arise without shared provenance and provide detector-specific reference bands. Existing methods remain far from saturating Launder-Bench: the strongest static method reaches only 0.66 AUROC on pairwise detection, while repository encoders rank the true source first on up to 22% of attribution queries but earn calibrated attribution credit on only 1-2%. These results reveal a systematic gap between relative code similarity and source-specific provenance evidence, providing a reproducible target for provenance detection under agentic rewriting.
Mixture-of-Experts (MoE) architecture has been widely adopted in large language models (LLMs) since it reduces the computational cost through sparse expert activation. However, the massive parameter scale of MoE models hinders their deployment on resource-constrained edge devices. Although existing mixed-precision quantization reduces the model size, they are inherently static, fixing the bit-width of each expert across decoding steps. Such static schemes yield suboptimal performance as they overlook the dynamic variation in expert importance during decoding. Furthermore, they fail to adapt to the dynamic latency constraint driven by the fluctuating system utilization. To address these challenges, we propose MatMoE, a dynamic mixed-precision quantization framework for efficient MoE inference. MatMoE features: (1) a Matryoshka MoE PTQ algorithm that enables experts to operate flexibly at multiple precisions within a stringent memory budget; (2) a floor-and-compensation quantization method that eliminates redundant memory accesses in the Matryoshka representation; and (3) a dynamic bit-width allocation strategy that determines the precision for each expert based on their routing scores to satisfy the dynamic latency requirement. We implement our MatMoE system atop llama.cpp for both CPU and GPU platforms. Extensive evaluations across three modern MoE models and challenging benchmarks demonstrate that MatMoE achieves $4.0\% \sim 18.3\%$ higher accuracy than state-of-the-art static mixed-precision method. Compared to llama.cpp, MatMoE delivers $1.3\times \sim 3.7\times$ speedup on Raspberry Pi 5, and $1.2\times \sim 1.3\times$ speedup on NVIDIA RTX 4090 and Jetson AGX Orin.
AI 速览：提出一个把多智能体协作规则作为可配置维度、用于评测LLM服务系统与GPU/NPU硬件行为的基准。
Large language model (LLM)-based multi-agent systems (MAS) coordinate specialized agents to solve complex tasks, turning each user request into interdependent model and tool operations. Unlike independent requests, these operations become ready at different times and consume evolving context as agents coordinate and exchange results. This creates changing patterns of concurrency, computation, and memory demand that can expose different bottlenecks in LLM serving hardware. Yet benchmarking these effects requires capturing the collaboration rules that generate serving workloads, beyond the requests observed during execution. We present MAServeBench, a benchmark that treats multi-agent collaboration as a configurable dimension of serving workloads for LLM serving and hardware evaluation. Its composable stages capture how agents coordinate and exchange context in documented MAS workflows, enabling native executions to generate different workloads even when task inputs and tools remain unchanged. Hierarchical Semantic Traces preserve realized operations and dependencies for reproducible comparisons of legal release constraints at fixed work. Task-linked measurements connect these workloads to serving execution and GPU/NPU hardware behavior, revealing why serving efficiency does not always translate into timely task completion. The benchmark code is available at https://github.com/ShengxuanQiu/MAServeBench.
Chumeng Liang, Linxuan Wang, Xinyu Peng, Huabin Liu, XiaoXu Guo, Yuxin Chen, Ge Liu, Guang Lin 等 10 位作者
Speculative decoding accelerates language model inference by verifying multiple draft tokens in a single target-model pass. Recent parallel drafters have achieved breakthrough performance in frontier production models, but their effectiveness deteriorates as the entropy of target distributions increases due to insufficient draft diversity. To overcome this bottleneck without sacrificing parallelism, we introduce UBTree, a parallel drafter that couples a Unigram proposer with a Bigram selector to construct drafting Trees. The unigram proposer is trained with the standard cross-entropy objective to generate candidate tokens independently for each position, while a lightweight bigram selector predicts transition scores between adjacent candidate pairs. Unlike the proposer, the selector is trained with a renormalized KL objective on high-temperature data. This tree-native training broadens the supervision beyond the greedy path, encouraging plausible alternative branches that improve the chance of accepting additional tokens during tree verification. Across seven standardized benchmarks with Qwen3-4B and Qwen3-8B, UBTree achieves an average speedup of $5.84$--$6.94\times$ over autoregressive decoding and outperforms DARTree in all 28 comparisons. Production-scale evaluation further demonstrates UBTree's advantage over frontier baselines such as DSpark.
BiliPicks documents seven years of Bilibili's Weekly Picks, a platform-curated editorial video series. The dataset covers 371 publicly listed issues and 13,758 curated videos from 22 March 2019 to 7 May 2026. It links issue dates, themes and editorial recommendations to video metadata, 47,799,657 top-level comments, 125,690,760 time-synchronised overlay comments (danmaku), and 13,739 cover images. Weekly issues provide a consistent unit for tracing changes in category composition, recurring creators and editorial framing. Corresponding comments and danmaku connect video-level discussion with audience expressions tied to particular moments, while covers add a visual dimension. We evaluate retrieval coverage and illustrate longitudinal analyses of selection, audience language and cover presentation. BiliPicks provides a dataset for future studies of platform curation, linking changes in published selections to their editorial framing and corresponding audience engagement.
Ke Zou, Nan Zhou, Tao Yang, Meng Liu, Linchao He, Zehui Liao, Ling Huang, Guangren Huang 等 12 位作者
Medical vision-language models (VLMs) show strong performance in radiology report generation (RRG) and medical visual question answering (Med-VQA), producing free-form clinical descriptions and answers from medical images. However, they may generate clinically meaningful statements that lack visual evidence or contradict image content. We refer to these errors as visually irrelevant hallucinations and investigate them at the phrase level. We propose CLEAR (Counterfactual Localized Evaluation of Alignment and Response), a model-agnostic post-hoc framework for phrase-level hallucination risk estimation. CLEAR decomposes generated responses into visually assessable clinical phrases. For each phrase, phrase-conditioned grounding identifies a candidate visual region, which is selectively perturbed by a localized counterfactual intervention. CLEAR characterizes the intervention using two complementary auditing cues: response cues, capturing semantic and clinically meaningful changes in the generated response, and alignment cues, measuring changes in image-phrase compatibility. These cues are normalized and jointly modeled to estimate phrase-level hallucination risk. Across four datasets spanning RRG and Med-VQA, CLEAR outperforms state-of-the-art hallucination detection baselines across multiple medical and general-purpose VLMs. On MIMIC-CXR, CLEAR improves AUPRC from 85.10% to 90.23%. Its effectiveness is further validated on a GT-derived controlled VIH benchmark. These results establish visually irrelevant hallucination as an important fine-grained reliability failure mode in medical VLMs and demonstrate the value of model-agnostic visual-support auditing for more trustworthy multimodal clinical generation.
Electroencephalography (EEG)-to-language models offer a promising approach for translating complex neural signals into human-readable descriptions. However, generating plausible language does not necessarily demonstrate that a model has learned to interpret the underlying EEG signal. A direct way to assess such interpretation is to probe objectively measurable properties of the signal itself. We therefore construct an EEG-language dataset of 160,781 segments annotated with signal-level question answering (QA) pairs, where each question targets one of five property families and requires a quantitative comparison involving spectral, spatial, temporal, or lateral signal properties. Each segment is also paired with a feature-grounded EEG caption. We further propose a Dual-Domain EEG Encoder that jointly models temporal waveforms and spectral-spatial representations, and introduce EEG-Captioner, a unified EEG-to-language framework trained with both signal-level QA and EEG caption supervision. Experiments show that the proposed encoder achieves the highest overall macro-averaged balanced accuracy (Macro-BA) among the compared EEG encoders, while EEG-Captioner achieves a Macro-BA of 88.81% on signal-level QA and improves caption factual consistency from 82.06% to 83.46% over caption-only language adaptation, demonstrating the complementary benefits of signal-level QA and caption supervision. Demo page: https://lyJinAoki.github.io/EEG-Captioner/.
Mental health research on social media has been dominated by English-language datasets and DSM-5-centered resources, limiting cross-lingual and cross-cultural understanding of online mental health expression. We introduce MATCHA, the first Chinese multi-disorder mental health dataset that links disorder-specific Weibo Super-Topic communities with users' broader public timelines. MATCHA covers seven DSM-5 disorders and a control group, comprising 46,025 cohort-level users and 1.8 million posts. The dataset distinguishes users with explicit self-disclosure evidence from broader disorder-related participants through an LLM-assisted annotation pipeline, and is released in a rigorously de-identified, controlled-access format. Using MATCHA, we analyze behavioral, linguistic, symptom-related, and life-event-related patterns across disorders, and conduct cross-lingual comparisons with Twitter-STMHD. Our analyses show that Weibo Super-Topics function as concentrated spaces for affective and health-related expression, while cross-platform differences between Weibo and Twitter often exceed cross-disorder variation. MATCHA provides a new resource for community-aware and cross-lingual mental health NLP research.
Yixue Zhang, Kun Wu, Zhi Gao, Zhen Zhao, Pei Ren, Zhiyuan Xu, Fei Liao, Xinhua Wang 等 15 位作者
The pursuit of general-purpose robotic manipulation is hindered by the scarcity of diverse, real-world interaction data. Unlike large-scale web vision-language data, robotic data collection incurs prohibitive physical costs. The key challenge is thus not merely to collect more robot data, but to obtain informative training data that broadens behavioral coverage across objects, scenes, and skills. Yet automatically curating task proposals to maximize the utility of collected data remains under-explored. We introduce RoboGene, an agentic framework for generating diverse, informative manipulation tasks across single-arm, dual-arm, and mobile robots. RoboGene combines (1) diversity-driven sampling for broad task coverage, (2) agentic self-reflection for task-quality assessment, and (3) human-verified feedback memory for execution-grounded validation and continual refinement. Through quantitative analysis and large-scale real-world experiments, we collect 18k trajectories and introduce metrics for task feasibility and diversity. RoboGene significantly outperforms frontier foundation models, including GPT-4o and Gemini 2.5 Pro. VLA models trained on RoboGene-generated data achieve higher success rates and stronger generalization, highlighting the value of high-quality task generation. Project page: https://robogene-boost-vla.github.io/. Datasets: Hugging Face (https://huggingface.co/datasets/X-Humanoid/RoboGene) and ModelScope (https://modelscope.cn/datasets/X-Humanoid/RoboGene_tasks).
Ki Sen Hung, Xi Yang Hong Kong University of Science and Technology, Chang Liu University of Science and Technology of China, Haoran Li, Kejiang Chen University of Science and Technology of China, Changxuan Fan, Tsun On Kwok The Hong Kong University of Science and Technology, Weiming Zhang University of Science and Technology of China 等 10 位作者
A central goal of LLM alignment is to balance helpfulness with harmlessness, yet these objectives conflict when the same knowledge serves both legitimate and malicious purposes. This tension is amplified by context-sensitive alignment: we observe that domain-specific contexts (e.g., chemistry) selectively relax defenses for domain-relevant harmful knowledge, while safety-research contexts (e.g., jailbreak studies) trigger broader relaxation spanning all harm categories. To systematically exploit this vulnerability, we propose Jargon, a framework combining safety-research contexts with multi-turn adversarial interactions that achieves attack success rates exceeding 93% across seven frontier models, including GPT-5.2, Claude-4.5, and Gemini-3, substantially outperforming existing methods. Activation space analysis reveals that Jargon queries occupy an intermediate region between benign and harmful inputs, a gray zone where refusal decisions become unreliable. To mitigate this vulnerability, we design a policy-guided safeguard that steers models toward helpful yet harmless responses, and internalize this capability through alignment fine-tuning, reducing attack success rates while preserving helpfulness.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Meng Li, Lei Li Tencent, Xiting Wang Renmin University of China, Yi Yuan, Zheng Wei Tencent Technology (Beijing) Company Limited, Brucebian Tencent AI Lab, Zang Li Tencent
Agentic reinforcement learning enables large language models to solve long-horizon tasks by interacting with the environment and internalizing tool-use behavior into their reasoning. Prior work assigns supervision primarily based on outcome rewards or external reward models, but largely ignores environment observations, a critical source of learning. Consequently, agents may identify successful actions without understanding how the environment responds, producing suboptimal policies. To address this, we propose SOAR (Supervision from Observation for Agentic Reinforcement Learning), which assigns positive advantages to observation tokens proportional to the negative entropy of preceding actions. This encourages the agent to learn from outcomes of confident actions, grounding policy updates in environment dynamics and improving anticipation of tool-call consequences. Empirical results across three domains and 14 benchmarks show that SOAR improves performance, yielding gains of up to 7.0% on general reasoning tasks and 16.9% on deep research tasks, while reducing erroneous and inefficient tool usage.
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cs.CL · cs.AI
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Runyang You Hong Kong Polytechnic University, Yongqi Li Hong Kong Polytechnic University, Meng Liu Shandong University and Shandong Jianzhu University, Wenjie Wang University of Science and Technology of China, Liqiang Nie Harbin Institute of Technology (Shenzhen) and Shandong University, Wenjie Li The Hong Kong Polytechnic University, The Hong Kong Polytechnic University
Parallel test-time scaling (TTS) is a pivotal approach for enhancing large language models (LLMs), typically by sampling multiple token-based chains-of-thought in parallel and aggregating outcomes through voting or search. Recent advances in latent reasoning, where intermediate reasoning unfolds in continuous vector spaces, offer a more efficient alternative to explicit Chain-of-Thought, yet whether such latent models can similarly benefit from parallel TTS remains open, mainly due to the absence of sampling mechanisms in continuous space, and the lack of probabilistic signals for advanced trajectory aggregation. This work enables parallel TTS for latent reasoning models by addressing the above issues. For sampling, we introduce two uncertainty-inspired stochastic strategies: Monte Carlo Dropout and Additive Gaussian Noise. For aggregation, we design a Latent Reward Model (LatentRM) trained with step-wise contrastive objective to score and guide latent reasoning. Extensive experiments and visualization analyses show that both sampling strategies scale effectively with compute and exhibit distinct exploration dynamics, while LatentRM enables effective trajectory selection. Together, our explorations open a new direction for scalable inference in continuous spaces. Code and checkpoint are included as supplementary materials.GitHub Project: https://github.com/ModalityDance/LatentTTS
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Zhizhang Fu, Yuancheng Gu, Chenkai Hu New York University, Hanmeng Liu Hainan University, Yue Zhang Westlake University
Test-time scaling has enabled Large Language Models (LLMs) to tackle complex reasoning, yet the limitations of current Chain-of-Thought (CoT) evaluation obscure whether performance gains stem from genuine reasoning or mere verbosity. To address this, (1) we propose a novel neuro-symbolic framework for the non-intrusive, comprehensive process-centric evaluation of reasoning grounded in First-Order Logic. (2) Through this lens, we identify four distinct behavioral prototypes and diagnose the failure modes. (3) We examine the impact of inference mode, training strategy, and model scale. Our analysis reveals that extended token generation is not a prerequisite for deep reasoning. Furthermore, we reveal critical constraints: mixing long and short CoT data in training risks premature saturation and collapse, while distillation into smaller models captures behavioral length but fails to replicate logical efficacy due to intrinsic capacity limits.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表