AI 速览：作者提出并发布OpenBrain，一个带置信度与可审计证据的全脑MRI生成分区标签数据集，让用户能按风险筛选、加权或复核生成标签。
Automatic tools can now generate whole-brain MRI parcellations at cohort scale, but generated-label releases often provide little evidence about which cases are reliable enough to reuse. We introduce OpenBrain, a confidence-aware release of 35,838 provenance-verified OpenNeuro T1w cases from 607 source datasets. OpenBrain is organized as an auditable case-record release rather than a directory of standalone segmentation files: each record links a primary parcellation, two committee parcellations, source/license provenance, raw QC-7 measurements, percentile risks, a combined risk score R, and a confidence tier. QC-7 is a reference-free reliability panel over label geometry, image-label consistency, and committee disagreement, so users can filter, weight, audit, or re-threshold generated labels without rerunning inference. We evaluate this released evidence under a frozen protocol. Across external cohorts, lower QC-7 risk corresponds to higher generated-label quality; in fixed-budget training, lower-risk selections improve paired macro Dice over random selection by +3.2 to +3.7 percentage points. OpenBrain also exposes raw axes, committee outputs, provenance, and datasheet documentation, so confidence claims remain inspectable after download. It does not turn generated labels into manual annotations or clinical-grade segmentations. Its contribution is a large open generated-parcellation substrate, a reusable case-level risk-evidence layer, and an external validation protocol for release-time QC. Dataset: https://huggingface.co/datasets/lanqz7766/OpenBrain. Code: https://github.com/lanqz7766/openbrain.
Xinyan Zhao, Yi-Ching Tang, Victor J Cantu, Junseok Lee, Adam E Stogsdill, Ibraheem M Hamdi, Ashwin Kumar Ramesh, Zhiqiang An 等 10 位作者
Computational antibody design requires benchmarks that measure functional binding rather than similarity to natural sequences. Here we present AbBiBench, which treats the antibody--antigen complex as the evaluation unit and harmonizes 216,560 experimental measurements spanning 13 antibodies and 9 antigens. We compare 20 computational approaches without task-specific training or fine-tuning. The analyses show that global structure-conditioned inverse folding yields the strongest and most consistent affinity rankings, whereas antibody-specific fine-tuning does not consistently improve performance. Across models, rankings are more useful for prioritizing likely affinity gains than for excluding weak variants. In a subsequent case study, multi-objective evaluation of model-generated F045-092 CDR-H3 variants for H1N1 binding revealed a trade-off between predicted binding potential and evolutionary sequence plausibility; all 21 selected candidates produced H1-reactive ELISA signals. AbBiBench provides an open framework for developing and evaluating function-aware antibody design methods.
Fengxian Ji, Xie Yu, Zhexuan Cui, Yuke Li, Zirui Song, Fan Zhang, Qian Jiang, Jingpu Yang 等 11 位作者
Feedback-driven iteration is widely used to improve LLM-generated scientific ideas, but existing systems either leave revision decisions implicit in generation, align revisions with feedback-localized weaknesses, or restrict action selection to system-specific operations. This is problematic because problems, hypotheses, and solutions are interdependent: the location where a weakness manifests does not itself determine the revision scope that will produce a better successor. We term this phenomenon diagnosis-intervention mismatch. We introduce Predictive Routing of Interventions by Modeling Effects (PRIME), a plug-and-play feedback-to-revision decision layer for existing scientific ideators. PRIME operates in three stages: (1) Structural Attribution interprets feedback over the problem-hypothesis-solution structure without fixing a revision target; (2) Counterfactual Routing constructs alternative scope-conditioned interventions and compares their projected successor utility and risks through lightweight rollouts; and (3) Intervention Execution compiles the selected intervention into an ordered generator-facing plan with semantic actions, preservation constraints, and dependency requirements for successor generation. We validate diagnosis intervention mismatch on 112 human-annotated idea-feedback pairs. Across four benchmarks, two ideators, and fixed- and open-problem settings, PRIME improves successor quality and routing reliability over strong baselines; removing counterfactual routing reduces quality from 3.463 to 1.960 and increases route regret from 0.426 to 1.929, confirming cross-scope effect modeling as the primary source of its gains.
LLM agents learn by interacting with environments, yet existing environments are designed for specific tasks and fail to generalize to new ones. Recent methods automate environment construction with LLMs. However, they generate each environment from scratch, neither reusing parts shared across environments nor carrying a fix from one environment to the rest. To address this, we propose a new paradigm of evolving environment atoms, which composes environments from reusable atoms (intent, rule, data and server) and evolves the atoms when an environment fails to give reliable feedback (e.g., an application lacks a tool the task requires). To instantiate this paradigm, we introduce LegoEnv, which builds 5,465 verified environments over 223 applications, and one round of evolution raises the share of solvable environments from 71.6% to 88.3%. On AutomationBench, SFT on these environments lifts Qwen3.6-27B from 16.0% to 32.0%, and RL with their verifiers lifts Qwen3.8-27B from 37.6% to 40.3%. Further analyses show steady gains with corpus size, transfer to unseen applications, and failures concentrated in a few shared root causes.
We present Youtu-Parsing-Omni, an omni-modal parser that converts documents, images, audio, and video into structured records grounded in space and time, providing a perception layer for agents that read, locate, and cite evidence across modalities. Its design rests on one encoder for every modality and one schema for every task. Youtu-Omni-Encoder, initialized from a pre-trained language model to strengthen text reading, encodes all modalities with shared weights in a unified space-time coordinate system, and a few fusion layers let video frames attend to concurrent audio, bringing cross-modal fusion and temporal alignment into perception itself. OmniSchema unifies the outputs of all ten parsing tasks, allowing a single self-evolving post-training procedure, OmniSchema-Aware On-Policy Distillation (OSAD), to provide a shared token-role-based objective across tasks. In each round, the model is trained on its own rollouts against token-level targets from a reference-conditioned copy of itself, which is then refreshed with the trained weights, so that the parser and its supervision co-evolve. With a single 5 B-parameter checkpoint, Youtu-Parsing-Omni achieves state-of-the-art performance on OmniDocBench v1.6 (96.96 Overall) and leads all open-weight models on OmniParsingBench (75.08 Avg.), with its advantage concentrated on audio and video. It also achieves the best overall chart-parsing score (95.02) and the highest exact chemical-fingerprint agreement among compared systems, and matches a dedicated optical-music model in character-level transcription of typeset sheet music while staying far ahead of general-purpose systems. Code and model weights are publicly available.
Zirui Song, Qian Jiang, Mingxuan Cui, Mingzhe Li, Lang Gao Mohamed bin Zayed University of Artificial Intelligence, Zeyu Zhang Australian National University, Zixiang Xu, Yanbo Wang Mohamed bin Zayed University of Artificial Intelligence 等 11 位作者
The rise of Large Audio-Language Models (LAMs) brings both potential and risks, as their audio outputs may contain harmful or unethical content. However, current research lacks a systematic, quantitative evaluation of LAM safety, especially against jailbreak attacks, which are challenging due to the temporal and semantic nature of speech. To bridge this gap, we introduce AJailBench, the first benchmark specifically designed to evaluate jailbreak vulnerabilities in LAMs. We begin by constructing -Base, a dataset of 1,495 adversarial audio prompts spanning 10 policy-violating categories. Using this dataset, we evaluate several state-of-the-art LAMs and reveal that none exhibit consistent robustness across attacks. To further strengthen jailbreak testing and simulate more realistic attack conditions, we propose a method to generate dynamic adversarial variants. Our Audio Perturbation Toolkit (APT) applies targeted distortions across time, frequency, and amplitude domains. To preserve the original jailbreak intent, we enforce a semantic consistency constraint and employ Bayesian optimization to efficiently search for perturbations that are both subtle and highly effective. This results in AJailBench-APT+, an extended dataset of optimized adversarial audio samples. Our findings demonstrate that even small, semantically preserved perturbations can significantly reduce the safety performance of leading LAMs, underscoring the need for more robust and semantically aware defense mechanisms. We release AJailBench to facilitate future research: https://anonymous.4open.science/r/AudioJailbreak-4262/
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Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表