Roxanne De Maeyer, Ine Dirks, Yannick Brackenier, Simon DeKeyser, Jef Vandemeulebroucke, Vicky De Ridder
The HECKTOR 2026 challenge benchmarks machine learning for head and neck cancer, where teams delineate primary and nodal tumour volumes, perform TN staging, and predict recurrence-free survival (RFS). This report describes the submissions for the HECKTOR challenge of team nucli. As the three tasks span both dense and global information from multicentric PET/CT scans, we utilise self-supervised pre-trained encoders, training a 2D DINOv2 encoder (PET-DINOv2-MIPs) on HECKTOR 2026's PET scans. Our final test submission ensembles a DynUNet trained from scratch with a SwinUNETR whose Swin trunk was initialised from a SimMIM-pre-trained checkpoint for segmentation, reaching a mean Dice of 0.5409. For TN staging, GTVp/GTVn geometric features from the segmentation masks are fit to stage probabilities by logistic regression (LR) and fused with PET-DINOv2-MIPs deep features (PCA + LR) via a second-level LR, reaching balanced accuracies of 0.3962 (T-stage) and 0.6432 (N-stage). For the RFS prognosis task, we fine-tune the last two blocks of the PET-DINOv2-MIPs ViT-S encoder jointly with an MLP head under a CoxPH loss, concatenating clinical covariates with the imaging features, reaching a test Harrell's C-index of 0.6577 and a weighted challenge score of 0.5802. The prognosis result is comparable to the best entry of the previous edition and consistent with our internal cross-validation, while our segmentation result is well below it and limits the staging results that depend on it.
Roxanne De Maeyer, Yannick Brackenier, Vicky De Ridder, Simon DeKeyser, Maarten Larmuseau, Jef Vandemeulebroucke
DINO (self-DIstillation with NO labels) has become a stan- dard for self-supervised pre-training, producing features that generalise across datasets and downstream tasks. In medical imaging it has been adopted mainly for radiology (X-ray, CT and MRI), where even natural- image DINO features transfer well. In the literature, these features have been reported to transfer worse to functional imaging such as PET. Yet PET-specific DINO models have barely been introduced, and even less validated across multiple tasks and datasets. We present PET-DINOv2-2D, the first DINOv2 model pre-trained on 2D PET, and benchmark it against open-source encoders: the origi- nal DINOv2 (pre-trained on the LVD-142M natural-image dataset) and OmniRad (pre-trained on CT, MRI and ultrasound). Using the same lightweight heads for every backbone, and despite far less pre-training data, PET-DINOv2-2D matches or outperforms both on three down- stream PET tasks: normal/abnormal classification, lesion segmentation and recurrence-free survival prognosis. Its advantage is largest when few labels are available, suggesting that PET pre-training gives more transferable, label-efficient features. Code is made available at https://github.com/nuclivision/pet-dinov2-2d/.