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以技能为中心的智能体推进临床基因组分析

Advancing Clinical Genomic Analysis with a Skill-Centred Agent

Qiaoyu Zheng, Weike Zhao, Yanjie Fan, Ye Cao, Mengqi Jiang, Xiao Zhou, Xiaoman Zhang, Pengcheng Qiu 等 13 位作者

AI 速览：作者提出基于大语言模型的智能体 ClinGeX，通过检索与依赖感知编排 105 个可执行技能来辅助临床基因组解读，并在基准与人类-AI 协作研究中报告了优于对照的表现。登录阅读完整解读 →

Clinical genomic analysis requires experts to integrate evolving guidelines, databases, and computational evidence. As sequencing has become increasingly accessible, this complex and labor-intensive process has become a major bottleneck to the timely use of genomic information in clinical decision-making. To fill this gap, we developed ClinGeX, a large-language-model agent that composes 105 curated executable skills through task-specific retrieval and dependency-aware orchestration. On 223 temporally held-out benchmark cases, ClinGeX achieved 71.7\% macro-averaged task-level concordance with expert reference classifications, compared with 45.7\% for the strongest comparator. In a three-condition, counterbalanced human-AI collaboration study, 45 clinical genomic professionals assessed 135 clinically derived cases under routine (no AI assistance), DeepSeek-assisted and ClinGeX-assisted conditions. ClinGeX assistance increased raw case-level concordance across criterion-level variant analysis, genomic interpretation in rare disease and molecular oncology decision-making (51.1\%, 57.8\%, 64.4\% versus 15.6\%, 31.1\%, 20.0\% in comparator conditions) and reduced reported interpretation time in all scenarios. During an exploratory one-month real-world non-interventional assessment, 11 experienced professionals submitted feedback on 96 self-selected analysis episodes and reported frequent conclusion adoption and time savings. These findings support executable domain skills as a promising approach to augment specialist genomic interpretation.

As the Story Unfolds: Watching a Film and Identifying Characters as a Human Does

Zhongrui Gui, Junyu Xie, Tengda Han, Weidi Xie, Andrew Zisserman

Films introduce characters incrementally as they progress. We study the problem of identifying principal characters and assigning their names directly from the movie itself, without using external cast lists, actor photographs, or pre-built character banks. We introduce the character naming task: given a name mentioned in dialogue and the associated video context, the model must determine which visible character bears that name. This task is challenging because name resolution often depends on cinematic cues such as shot-reverse-shot structure, self-introduction, direct address, third-party reference, gaze, and temporal continuity. We provide a dataset and annotations for evaluating character naming and first character appearances, develop a video-and-dialogue model for the task, and compare it with proprietary multimodal large language models. We further introduce a progressive framework for building a character bank as the film unfolds. Together, these contributions support online, human-like movie understanding in which character identities are inferred from the film itself.

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