A 3D foundation model unifying CT interpretation and segmentation
Yulu Xie, Zilong Li, Shen Xu, Yifan Bai, Liuhong Shi, Jiao Chen, Xianglei Kong, Wenchao Zhu 等 17 位作者
Radiologists interpret computed tomography (CT) scans by jointly determining what a finding represents and where it lies in three-dimensional (3D) anatomy. However, CT models have treated CT interpretation and 3D segmentation as separate tasks, leaving textual findings spatially unverifiable and overlooking potential synergy between clinical understanding and spatial perception. Here we present HoloCT, a generalist 3D foundation model unifying CT interpretation and voxel-level segmentation by jointly modelling whole-volume context and fine-grained anatomical detail, providing 3D masks as evidence. We curated HoloDATA, comprising 195,921 CT scans from 73 public datasets and six clinical cohorts, with 6.2 million instruction dialogues and 2.8 million CT-mask pairs. Across 346 tasks spanning segmentation, lesion screening, visual question answering, and report generation on 61 internal and 12 external datasets, HoloCT outperformed specialist and foundation models. In multicentre validation across 11,455 clinical CT scans from five hospitals, HoloCT outperformed competing models in lesion segmentation and report generation by 18.2 and 15.3 points. It also achieved 85.1% mean accuracy in screening thyroid tumours and colon lesions, exceeding all four participating radiologists in a retrospective reader study. Further analyses revealed bidirectional semantic-spatial synergy: language-guided segmentation delineated unseen anatomical structures and lesions as well as diffuse free-text findings, outperforming the leading approach by 22.1 points, whereas prompting the model to generate corresponding 3D masks alongside its textual outputs significantly improved interpretation performance. HoloCT shows that clinical understanding and spatial perception can be learned together within a single foundation model and offers a path towards more accurate and reliable CT analysis.
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