Xiangyu Li, Jincheng Li, Xing Xie, Bin Guan, Shaohua Kevin Zhou, Rui Yan, Ran Su
Whole-slide multiple instance learning can predict diagnostic and prognostic labels from tissue composition while making limited use of spatial organization. Providing coordinates or a graph does not establish that a trained predictor uses tissue neighborhoods. We examine this gap as spatial blindness and hypothesize that early composition learning can weaken supervision of a spatial pathway. We introduce ResTopoMIL, which freezes a learned composition predictor before training a graph residual with a coordinate-reassignment separation loss. Permutation and information analyses distinguish architectural symmetry, available spatial information and the proposed optimization mechanism. On a controlled spatial task, staged training achieved an AUC of 0.987, compared with 0.684 for the same jointly trained architecture. Performance remained high on a composition-only task. Across four WSI classification and five survival benchmarks, ResTopoMIL improved mean primary performance on eight tasks; four improvements remained significant after Holm-adjusted patient-cluster tests. Coordinate-free residual controls recovered some of the gains, while neighborhood destruction reduced performance close to the composition anchor. Neighborhood-preserving transformations and anatomy-stratified perturbations further characterized this dependence. These results support fixing a composition reference as a practical intervention for learning spatial corrections, while retaining additional appearance capacity as a contributing explanation.
Xiangyu Li, Jincheng Li, Tianle Du, Yanheng Li, Haoxuan Che, Yuxin Sun, Long Bai, Liangliang Liu 等 9 位作者
A question about a whole-slide image rarely names every morphological finding needed to answer it. Question-guided patch selection can therefore overlook supporting morphology, while slide-level compression can dilute focal evidence. Inspired by how pathologists combine broad slide review, question-directed examination, and integration of their findings, we introduce BEYONDPATH, a Preserve-Focus-Fuse framework for whole-slide image question answering. Preserve learns a question-agnostic Morphology Bank through answer supervision across multiple questions about each training slide. Focus retrieves questionspecific evidence from all foreground patches, including regions outside the Bank. Fuse integrates the preserved morphology at the retrieved evidence positions through Morphology-on-Visual-Evidence Fusion, producing a fixed 96-token visual prefix. On WSI-Bench, BEYONDPATH achieves an Avg-9 of 0.769 and leads all eight reported report-generation metrics using the same checkpoint. It also achieves 0.639 zero-shot overall accuracy on SlideBench-BCNB. Controlled ablations show complementary benefits from morphology preservation and question-directed retrieval, and support cross-question supervision and fusion at the evidence positions. These results support looking beyond the question's explicit cues: preserving broader slide morphology while retaining the ability to seek evidence for each question.
Xiangyu Liu, Zeting Yan, Zhitong Yin, Boyang Li, Xi Zhang
Background and Objective: Predicting regional blood-oxygen-level-dependent (BOLD) activity from EEG provides a computational approach to studying electrophysiological-hemodynamic associations. However, changes in input representation, readout architecture, and ensembling can obscure the source of a prediction gain. We investigate the contribution of target-relative spectral estimation under matched readout conditions. Methods: MEL converts each preceding 16-second EEG history into calibrated lag-channel-frequency measurements. Four equal-dimensional representations are compared using matched Ridge and multilayer perceptron (MLP) readouts. The retrospective analysis includes 29 resting-state scans from 22 participants, participant-paired uncertainty estimates, aggregation and correspondence controls, leave-one-participant-out regression, and refitted models on an external Oddball cohort. Results: Morlet-Ridge achieved a mean scan-wise correlation of 0.508 across six regional targets and the global signal, compared with 0.432 for canonical Fourier features. The participant-paired mean difference was 0.069 (95% bootstrap confidence interval, 0.037-0.101), with improvements in 19 of 22 participants. The Morlet MLP prediction ensemble reached 0.491. Shared coordinate permutations preserved prediction after refitting, whereas sample-wise permutations degraded it. Canonical Fourier regression reached 0.377 under participant exclusion; external unseen-participant correlation was 0.026. Conclusions: Spectral estimation materially affected regional BOLD prediction without requiring additional nonlinear readout capacity. MEL provides an explicit measurement interface for controlled comparisons, but weak external results constrain its generalizability. Confirmation requires untouched participant-separated data and split-aware preprocessing.
RGB-X tracking complements RGB appearance with thermal, depth, or event observations, but centralized training requires collecting multimodal videos at a single location. Federated training keeps raw videos local, but sensor heterogeneity can create a mismatch between parameter-sharing domains and the clients contributing to them. This mismatch is particularly relevant when RGB-only clients coexist with sensor-equipped clients: their RGB observations remain useful, but they provide no auxiliary measurements for learning sensor-dependent interactions. We propose Fed-MAPTrack, a modality-aware federated prompt tuning framework for RGB-X tracking. The pretrained tracking backbone and prediction head are frozen, and clients optimize and exchange only prompt-related parameters. The server aggregates RGB-shared parameters globally and maintains separate thermal, event, and depth banks for auxiliary-specific, fusion, and normalization parameters. Selective participation retains RGB-only clients' contributions to the global RGB bank while excluding their fusion and normalization updates from modality-specific aggregation. Across three matched training repetitions under a fixed client partition, Fed-MAPTrack improves the mean FedAvg scores by 2.35 AUC points on LasHeR, 3.45 SR points on VisEvent, and 2.11 F-score points on DepthTrack. Among the nine evaluated methods, it achieves the highest mean thermal AUC and depth F-score, while its mean event SR is 0.07 points below that of Independent FL. Controlled ablations show that extending the bucketing scope without a compatible participation rule can reduce performance. These results highlight the need to jointly define the sharing domain and eligible contributors for each parameter group.