AI 速览：作者提出基于大语言模型的智能体 ClinGeX，通过检索与依赖感知编排 105 个可执行技能来辅助临床基因组解读，并在基准与人类-AI 协作研究中报告了优于对照的表现。
Clinical genomic analysis requires experts to integrate evolving guidelines, databases, and computational evidence. As sequencing has become increasingly accessible, this complex and labor-intensive process has become a major bottleneck to the timely use of genomic information in clinical decision-making. To fill this gap, we developed ClinGeX, a large-language-model agent that composes 105 curated executable skills through task-specific retrieval and dependency-aware orchestration. On 223 temporally held-out benchmark cases, ClinGeX achieved 71.7\% macro-averaged task-level concordance with expert reference classifications, compared with 45.7\% for the strongest comparator. In a three-condition, counterbalanced human-AI collaboration study, 45 clinical genomic professionals assessed 135 clinically derived cases under routine (no AI assistance), DeepSeek-assisted and ClinGeX-assisted conditions. ClinGeX assistance increased raw case-level concordance across criterion-level variant analysis, genomic interpretation in rare disease and molecular oncology decision-making (51.1\%, 57.8\%, 64.4\% versus 15.6\%, 31.1\%, 20.0\% in comparator conditions) and reduced reported interpretation time in all scenarios. During an exploratory one-month real-world non-interventional assessment, 11 experienced professionals submitted feedback on 96 self-selected analysis episodes and reported frequent conclusion adoption and time savings. These findings support executable domain skills as a promising approach to augment specialist genomic interpretation.
Monocular outdoor navigation requires robust camera motion estimation and a dense, navigable map, where 3D Gaussian Splatting SLAM serves this task through an explicit differentiable parameterization and closed-form projection. However, typically, the geometry is recovered by associating 2D pixels with 3D points, so a modular SLAM system absorbs tracking error into the map, leading to cascading degradation. To address these gaps, we present SG^2SLAM, which couples streaming spatial geometry with a ray-conditioned 3DGS kernel. Streaming spatial geometry replaces the per- frame cross-dimensional correspondence with a chunk-level metric prior that supervises tracking and mapping from one source. A ray-conditioned kernel extends each primitive with a viewing-direction subspace that senses the monocular camera viewpoints. The joint optimization over spatial geometry and poses ensures a globally consistent map and trajectory outcome. Experiments on the KITTI and Waymo Open datasets show that our SG^2SLAM surpasses the per-frame association baselines in the monocular outdoor navigation task. Code will be made publicly available upon acceptance.
Xiangxu Zhang Renmin University of China, Lei Li, Yanyun Zhou Renmin University of China, Xiao Zhou Renmin University of China, Yingying Zhang Tencent, Xian Wu Tencent
Medical diagnostics is a high-stakes and complex domain that is critical to patient care. However, current evaluations of large language models (LLMs) remain limited in capturing key challenges of clinical diagnostic scenarios. Most rely on benchmarks derived from public exams, raising contamination bias that can inflate performance, and they overlook the confounded nature of real consultations beyond textbook cases. Recent dynamic evaluations offer a promising alternative, but often remain insufficient for diagnosis-oriented benchmarking, with limited coverage of clinically grounded confounders and trustworthiness beyond accuracy. To address these gaps, we propose DyReMe, a dynamic benchmark for medical diagnostics that provides a controlled and scalable stress test of diagnostic robustness. Unlike static exam-style questions, DyReMe generates fresh, consultation-style cases that incorporate clinically grounded confounders, such as differential diagnoses and common misdiagnosis factors. It also varies expression styles to capture heterogeneous patient-style descriptions. Beyond accuracy, DyReMe evaluates LLMs on three additional clinically relevant dimensions: veracity, helpfulness, and consistency. Our experiments show that this dynamic approach yields more challenging assessments and exposes substantial weaknesses of stateof-the-art LLMs under clinically confounded diagnostic settings. These findings highlight the urgent need for evaluation frameworks that better assess trustworthy medical diagnostics under clinically grounded confounders.
尚无 AI 解读，展示原文摘要
cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Yixiao Zhou, Dongzhou Cheng, Zhiliang wu Nanyang Technological University, Yi Yang Zhejiang University, Yu Cheng Skywork AI and The Chinese University of Hong Kong, Hehe Fan Zhejiang University
Large Language Models (LLMs) often fail to utilize their latent reasoning capabilities due to a distributional mismatch between ambiguous human inquiries and the structured logic required for machine activation. Existing alignment methods either incur prohibitive O(N) costs by fine-tuning each model individually or rely on static prompts that fail to resolve query-level structural complexity. In this paper, we propose ReQueR (Reinforcement Query Refinement), a modular framework that treats reasoning elicitation as an inference-time alignment task. We train a specialized Refiner policy via Reinforcement Learning to rewrite raw queries into explicit logical decompositions, treating frozen LLMs as the environment. Rooted in the classical Zone of Proximal Development from educational psychology, we introduce the Adaptive Solver Hierarchy, a curriculum mechanism that stabilizes training by dynamically aligning environmental difficulty with the Refiner’s evolving competence. ReQueR yields consistent absolute gains of 1.3%–7.2% across diverse architectures and benchmarks, outperforming strong baselines by 2.1% on average. Crucially, it provides a promising paradigm for one-to-many inference-time reasoning elicitation, enabling a single Refiner trained on a small set of models to effectively unlock reasoning in diverse unseen Solvers. Code is available at https://github.com/newera-xiao/ReQueR.
尚无 AI 解读，展示原文摘要
cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Jiaxin Bai Hong Kong Baptist University, Wei Fan Hong Kong University of Science and Technology, Qi Hu, Qing Zong, Chunyang Li Department of Computer Science and Engineering, Hong Kong University of Science and Technology, Hong Ting Tsang, Hongyu Luo Hong Kong University of Science and Technology, Yauwai Yim 等 20 位作者
We present AutoSchemaKG, a framework for fully autonomous knowledge graph construction that eliminates the need for predefined schemas. Our system leverages large language models to simultaneously extract knowledge triples and induce comprehensive schemas directly from text, modeling both entities and events while employing conceptualization to organize instances into semantic categories. Processing over 50 million documents, we construct ATLAS (Automated Triple Linking And Schema induction), a family of knowledge graphs with 900+ million nodes and 5.9 billion edges. This approach outperforms state-of-the-art baselines on multi-hop QA tasks and enhances LLM factuality. Notably, our schema induction achieves 92% semantic alignment with human-crafted schemas with zero manual intervention, demonstrating that billion-scale knowledge graphs with dynamically induced schemas can effectively complement parametric knowledge in large language models.
尚无 AI 解读，展示原文摘要
cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表