Xinyue Xu, Jieqiang Sun, Jing, Dai, Siyuan Chen, Lanjie Ma, Ke Sun, Bin Zhao 等 12 位作者
A dexterous hand succeeds or fails through contact, yet every scalable record of human manipulation (video, vision-based hand tracking, motion capture) observes how the hand moves and misses how it pushes. We present DexCanvas, a hybrid real-synthetic dataset of 7,000 hours of dexterous hand-object interaction with per-frame contact points and contact forces, grown from 70 hours of optical motion capture that spans 21 manipulation types, from power and precision grasps to in-hand manipulation. The forces come from a real-to-sim pipeline: one reinforcement learning (RL) policy, conditioned on object geometry and manipulation type, drives an actuated MANO hand in physics simulation to reproduce each captured object trajectory, and the simulator measures the contacts that produce the reproduced motion. The policy reproduces 87.5% of the demonstrations and still succeeds on 80.9% of rollouts from perturbed initial object poses; these perturbed rollouts expand the 70 captured hours a hundredfold. On six YCB objects absent from the capture set it succeeds 72.5% of the time. The contact channels make better policies: a Diffusion Policy that observes DexCanvas contact features succeeds 82.2% of the time, against 67.5% without them, over 18,522 trials. Contact-driven retargeting carries the same demonstrations to two dexterous robot hands, where the RL stage again produces stable rollouts. A first release of 111,857 force-annotated trajectories is publicly available on Hugging Face.
Fang Wu, Hongbin Lin, Bingchen Duan, Yuchen Wang, Li Erran Li, Yanjie Huang, Mingxuan Cao, Yijun Ma 等 27 位作者
Protein-protein interactions underpin nearly all biological processes. Yet, designing proteins with desired interactions remains challenging due to the structural complexity governing molecular recognition. This study views protein design as a search optimization problem over a combinatorial sequence space under expensive structural evaluation. Toward this goal, we introduce a novel tree-based search framework, ProteoCraft, that employs approximate structural gradients from diffusion-based structure predictors as effective proposal policies to specify where the search should explore. Complete no-gradient inference of folding models separately assigns values to the resulting sequences, determining what is good. ProteoCraft allocates this verification budget through a coarse-to-fine paradigm: multi-site edits first explore distinct sequence basins, then verified promising states undergo strict single-site refinement. Across fourteen de novo binder-design settings spanning eight target proteins, five immune-relevant TCR-facing targets, and four localized CDR redesign tasks, ProteoCraft improves design quality and high-confidence yield. These improvements persist under independent AF2-IG and Rosetta-based interface evaluation. Prospective experimental validation further yielded an 82.9% binding hit rate for PD-L1 miniproteins, with a best measured KD of 0.879 nM, and confirmed binding of designed IFNAR2 VHH. Our code is available at https://github.com/smiles724/ProteoCraft_v1.
Xinyue Xu, Hongbin Lin, Juangui Xu, Hualiang Wang, Lehan Wang, Lijie Hu, Adrian Weller, Xiaomeng Li
Medical imaging modalities such as ultrasound and X-ray are widely used in clinical practice, where diagnosis follows a structured, evidence-driven workflow aligned with standardized criteria. While multimodal large language models (MLLMs) show promise for automated medical report generation, most existing systems rely on end-to-end multimodal fusion without modeling clinically defined intermediate attributes, leading to limited grounding and interpretability. To address this issue, we propose CORAL (COncept-grounded ReAsoning with Localization), a multimodal framework that integrates spatial grounding and concept-level supervision into a unified reasoning process. CORAL employs a prompt-driven medical segmentation model to localize lesions and predicts multi-class clinical attributes through a Concept Bottleneck module. The resulting textual concept tokens are combined with mask-modulated visual features within an MLLM to enable structured report generation and diagnostic prediction. Experiments on BUS-CoT and IU X-ray datasets demonstrate consistent improvements in diagnostic accuracy, concept consistency, and report quality over strong general-purpose and medical MLLMs, indicating that concept-grounded reasoning better aligns generation with clinical decision processes.