Disease diagnosis is a key application of large language model (LLM) agents in healthcare. However, existing medical agents are primarily trained and evaluated with static question-answering data, providing limited opportunities to learn active information acquisition, examination decision-making, and dynamic clinical interaction. To address this limitation, we present ClinVerse, an interactive, real-data-grounded multi-agent environment designed for training and evaluating medical diagnostic agents. Built on ClinPatient, a scalable dataset comprising 150k diagnostic cases derived from real-world electronic health records, ClinVerse supports coordinated interactions among six specialized clinical roles. Specifically, a doctor agent starts from an initial patient complaint, progressively gathers clinical evidence through patient interviews and examination requests, and ultimately produces a diagnosis. For each interaction trajectory, a rule-based scoring framework quantifies information acquisition, examination ordering, and diagnostic accuracy. These trajectory-level scores serve as reward signals for agent training while also enabling scalable evaluation. In experiments, we evaluate various general-purpose and medical-domain models and show that nine self-evolution methods across three categories consistently improve agents' diagnostic capabilities within ClinVerse. We further analyze the interplay among model capability, environment feedback, and self-evolution methods.
Xuanwen Ding, Chengjun Pan, Zejun Li, Jiwen Zhang Fudan University, Siyuan Wang The Chinese University of Hong Kong, Zhongyu Wei Fudan University
Evaluating multimodal large language models (MLLMs) is becoming increasingly expensive as benchmarks grow in scale and cross-modality complexity. Inspired by structuralism in cognitive psychology, we tackle this difficulty with an adaptive evaluation framework for efficient benchmarking, namely AutoJudger. Instead of passively scoring on a fixed test set, AutoJudger treats evaluation as an interview-like process by keeping a hypothesized ability structure of the evaluated model and actively selecting the informative questions so as to refine these ability boundaries. Specifically, AutoJudger has three core components: ability decomposition to organize evaluation along meaningful capability dimensions, ability estimation to maintain an up-to-date quantitative profile of the model competence, and adaptive question selection to choose the most informative questions. To operationalize this paradigm, we introduce A^2-Judger, a novel MLLM-based Agentic instantiation of AutoJudger equipped with semantic-aware retrieval and dynamic memory. Experiments on four representative multimodal benchmarks show that A^2-Judger significantly improves sample efficiency while maintaining reliable evaluation results.
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cs.CL · cs.AI · cs.CV
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表