AI 速览：作者提出基于大语言模型的智能体 ClinGeX，通过检索与依赖感知编排 105 个可执行技能来辅助临床基因组解读，并在基准与人类-AI 协作研究中报告了优于对照的表现。
Clinical genomic analysis requires experts to integrate evolving guidelines, databases, and computational evidence. As sequencing has become increasingly accessible, this complex and labor-intensive process has become a major bottleneck to the timely use of genomic information in clinical decision-making. To fill this gap, we developed ClinGeX, a large-language-model agent that composes 105 curated executable skills through task-specific retrieval and dependency-aware orchestration. On 223 temporally held-out benchmark cases, ClinGeX achieved 71.7\% macro-averaged task-level concordance with expert reference classifications, compared with 45.7\% for the strongest comparator. In a three-condition, counterbalanced human-AI collaboration study, 45 clinical genomic professionals assessed 135 clinically derived cases under routine (no AI assistance), DeepSeek-assisted and ClinGeX-assisted conditions. ClinGeX assistance increased raw case-level concordance across criterion-level variant analysis, genomic interpretation in rare disease and molecular oncology decision-making (51.1\%, 57.8\%, 64.4\% versus 15.6\%, 31.1\%, 20.0\% in comparator conditions) and reduced reported interpretation time in all scenarios. During an exploratory one-month real-world non-interventional assessment, 11 experienced professionals submitted feedback on 96 self-selected analysis episodes and reported frequent conclusion adoption and time savings. These findings support executable domain skills as a promising approach to augment specialist genomic interpretation.
Multi-view tracking extends visual coverage beyond a single camera, providing complementary observations when targets are occluded or leave the view. This raises a question: how can observations from different views be matched to the correct identities without offline scene-specific training or camera calibration? Progress toward this goal remains limited because many offline formulations assume such deployment-specific knowledge, while online adaptation can amplify association errors. We study this problem as online multi-view identity maintenance (OMIM): targets are initialized once per view, with no further identity labels provided after each initialization. To this end, we introduce OmniGlimpse, an asymmetric propose-verify framework that separates adaptive association from stable identity consolidation. At the representation level, short-term local and cross-view evidence is mapped into target-specific adaptive spaces to propose associations, whereas long-term identity distributions are maintained for verification in a canonical space defined by a frozen encoder. At the update level, short-term evidence may guide current associations, whereas, after bootstrapping, only verified observations may update persistent memory or drive adaptation. Under a unified target-specified evaluation protocol, OmniGlimpse improves over the best evaluated online baseline for each metric by 9.1 IDF1 and 22.1 CVIDF1 points on M3Track. The corresponding gains on MvMHAT are 20.3 and 26.2 points. Despite using no offline scene-specific training, it outperforms offline-trained references in IDF1 and remains competitive in cross-view association. These results support an approach to online identity maintenance that adapts to changing appearances while consolidating reliable evidence into stable identity anchors.
Shuyang Jiang, Yuhao Wang, Ya Zhang Shanghai Jiao Tong University, Yanfeng Wang Shanghai Jiao Tong University, Yu Wang Shanghai Jiao Tong University
Current critic-free RL methods for large reasoning models suffer from severe inefficiency when training on positive homogeneous prompts (where all rollouts are correct), resulting in waste of rollouts due to zero advantage estimates. We introduce a radically simple yet powerful solution to Mine intrinsic mastery (Miner), that repurposes the policy’s intrinsic uncertainty as a self-supervised reward signal, with no external supervision, auxiliary models, or additional inference cost. Our method pioneers two key innovations: (1) a token-level focal credit assignment mechanism that dynamically amplifies gradients on critical uncertain tokens while suppressing overconfident ones, and (2) adaptive advantage calibration to seamlessly integrate intrinsic and verifiable rewards. Evaluated across six reasoning benchmarks on Qwen3-4B and Qwen3-8B base models, Miner achieves state-of-the-art performance among the other four algorithms, yielding up to 4.58 absolute gains in Pass@1 and 6.66 gains in Pass@K compared to GRPO. Comparison with other methods targeted at exploration enhancement further discloses the superiority of the two newly proposed innovations. This demonstrates that latent uncertainty exploitation is both necessary and sufficient for efficient and scalable RL training of reasoning models. Code is available at https://github.com/pixas/Miner.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表