AI 速览：作者提出基于大语言模型的智能体 ClinGeX，通过检索与依赖感知编排 105 个可执行技能来辅助临床基因组解读，并在基准与人类-AI 协作研究中报告了优于对照的表现。
Clinical genomic analysis requires experts to integrate evolving guidelines, databases, and computational evidence. As sequencing has become increasingly accessible, this complex and labor-intensive process has become a major bottleneck to the timely use of genomic information in clinical decision-making. To fill this gap, we developed ClinGeX, a large-language-model agent that composes 105 curated executable skills through task-specific retrieval and dependency-aware orchestration. On 223 temporally held-out benchmark cases, ClinGeX achieved 71.7\% macro-averaged task-level concordance with expert reference classifications, compared with 45.7\% for the strongest comparator. In a three-condition, counterbalanced human-AI collaboration study, 45 clinical genomic professionals assessed 135 clinically derived cases under routine (no AI assistance), DeepSeek-assisted and ClinGeX-assisted conditions. ClinGeX assistance increased raw case-level concordance across criterion-level variant analysis, genomic interpretation in rare disease and molecular oncology decision-making (51.1\%, 57.8\%, 64.4\% versus 15.6\%, 31.1\%, 20.0\% in comparator conditions) and reduced reported interpretation time in all scenarios. During an exploratory one-month real-world non-interventional assessment, 11 experienced professionals submitted feedback on 96 self-selected analysis episodes and reported frequent conclusion adoption and time savings. These findings support executable domain skills as a promising approach to augment specialist genomic interpretation.
Hongcheng Liu, Yuhao Wang, Zhe Chen, Pingjie Wang, Zhiyuan Zhu, Yixuan Hou Shanghai Jiaotong University, Yanfeng Wang Shanghai Jiao Tong University, Yu Wang Shanghai Jiao Tong University
Omni Large Language Models (Omni-LLMs) have demonstrated impressive capabilities in holistic multi-modal perception, yet they consistently falter in complex scenarios requiring synergistic omni-modal reasoning. Beyond understanding global multimodal context, effective reasoning also hinges on fine-grained cross-modal alignment, especially identifying shared referents across modalities, yet this aspect has been largely overlooked. To bridge this gap, we formalize the challenge as a cross-modal coreference problem, where a model must localize a referent in a source modality and re-identify it in a target modality. Building on this paradigm, we introduce CrossOmni, a dataset comprising nine tasks equipped with human-designed reasoning rationales to evaluate and enhance this capability. Experiments on 13 Omni-LLMs reveal systematic weaknesses in cross-modal coreference, which we attribute to the absence of coreference-aware thinking patterns. To address this, we enhance cross-modal alignment via two strategies: a training-free In-Context Learning method and a training-based SFT+GRPO framework designed to induce such thinking patterns. Both approaches yield substantial performance gains and generalize effectively to collaborative reasoning tasks. Overall, our findings highlight cross-modal coreference as a crucial missing piece for advancing robust omni-modal reasoning.
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cs.CL · cs.CV
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Hongcheng Liu, Pingjie Wang, Yuhao Wang, Siqu Ou Shanghai Jiaotong University, Yanfeng Wang Shanghai Jiao Tong University, Yu Wang Shanghai Jiao Tong University
Multimodal large language models (MLLMs) have shown strong capabilities across a broad range of benchmarks. However, most existing evaluations focus on passive inference, where models perform step-by-step reasoning under complete information. This setup is misaligned with real-world use, where seeing is not enough. This raises a fundamental question: Can MLLMs actively acquire missing evidence under incomplete information? To bridge this gap, we require the MLLMs to actively acquire missing evidence and iteratively refine decisions under incomplete information, by selecting a target image from a candidate pool without task-specific priors. To support systematic study, we propose GuessBench, a benchmark with both perception-oriented and knowledge-oriented images for evaluating active reasoning in MLLMs. We evaluate 20 superior MLLMs and find that performance on active reasoning lags far behind it on passive settings, indicating substantial room for improvement. Further analysis identifies fine-grained perception and timely decision-making as key challenges. Ablation studies show that perceptual enhancements benefit smaller models, whereas thinking-oriented methods provide consistent gains across model sizes. These results suggest promising directions for future research on multimodal active reasoning.
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cs.CL · cs.CV
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
WenHao Wang, Peizhi Niu, Zhao Xu Hong Kong University of Science and Technology, University of California, Los Angeles and Tsinghua University, Zhaoyu Chen Tiktok, Jian Du TikTok, Yaxin Du, Xianghe Pang, Keduan Huang 等 11 位作者
Large Language Models (LLMs) increasingly rely on external tools to perform complex, realistic tasks, yet their ability to utilize the rapidly expanding Model Contextual Protocol (MCP) ecosystem remains limited. Existing MCP research covers few servers, depends on costly manual curation, and lacks training support, hindering progress toward real-world deployment. To overcome these limitations, we introduce MCP-Flow, an automated web-agent-driven pipeline for large-scale server discovery, data synthesis, and model training. MCP-Flow collects and filters data from 1166 servers and 11536 tools, producing 68733 high-quality instruction-function call pairs and 6439 trajectories, far exceeding prior work in scale and diversity. Extensive experiments demonstrate MCP-Flow’s effectiveness in driving superior MCP tool selection, function-call generation, and enhanced agentic task performance. MCP-Flow thus provides a scalable foundation for advancing LLM agents’ proficiency in real-world MCP environments.
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cs.CL · cs.AI
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Shuyang Jiang, Yuhao Wang, Ya Zhang Shanghai Jiao Tong University, Yanfeng Wang Shanghai Jiao Tong University, Yu Wang Shanghai Jiao Tong University
Current critic-free RL methods for large reasoning models suffer from severe inefficiency when training on positive homogeneous prompts (where all rollouts are correct), resulting in waste of rollouts due to zero advantage estimates. We introduce a radically simple yet powerful solution to Mine intrinsic mastery (Miner), that repurposes the policy’s intrinsic uncertainty as a self-supervised reward signal, with no external supervision, auxiliary models, or additional inference cost. Our method pioneers two key innovations: (1) a token-level focal credit assignment mechanism that dynamically amplifies gradients on critical uncertain tokens while suppressing overconfident ones, and (2) adaptive advantage calibration to seamlessly integrate intrinsic and verifiable rewards. Evaluated across six reasoning benchmarks on Qwen3-4B and Qwen3-8B base models, Miner achieves state-of-the-art performance among the other four algorithms, yielding up to 4.58 absolute gains in Pass@1 and 6.66 gains in Pass@K compared to GRPO. Comparison with other methods targeted at exploration enhancement further discloses the superiority of the two newly proposed innovations. This demonstrates that latent uncertainty exploitation is both necessary and sufficient for efficient and scalable RL training of reasoning models. Code is available at https://github.com/pixas/Miner.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表
Lina Yang Shanghai Jiaotong University, Yusheng Liao Shanghai Jiaotong University, Yanfeng Wang Shanghai Jiao Tong University, Yu Wang Shanghai Jiao Tong University
Large language models (LLMs) have achieved remarkable success across diverse tasks through large-scale pretraining. However, they remain prone to catastrophic forgetting in continual learning. To the best of our knowledge, this is the first work to identify noise accumulation in LoRA updates as a key cause of forgetting in continual learning. A preliminary two-task experiment demonstrates that removing less important components of the second task’s LoRA parameters improves performance on the first task, suggesting that later updates introduce noisy interference. Building on this insight, we propose Subspace-Denoised Low-Rank Adaptation (SLoRA), a simple and effective framework that filters noisy components from LoRA updates via subspace similarity with the base model. SLoRA is a regularization-free method without accessing data or gradients from previous tasks or modifying the training process. It offers two variants, SLoRA-Pre and SLoRA-Post, for online and offline continual learning, respectively. Extensive experiments across tasks and models validate the effectiveness of SLoRA. It improves final accuracy by up to 12%, reduces forgetting by 29%, and filters out over 30% of LoRA parameters identified as noisy. Our code is available at https://github.com/alina1031/SLoRA.
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cs.CL
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表