Diagnosis by Composition: Detecting and Localizing Unseen Diseases by Composing Learned Radiological Findings
Kaihua Hou, Wei Liu, Yi Huang, Hao Zhang, Haibo Jin, Yifei Sun, Yuan gao, Zuoou Li 等 13 位作者
AI 速览：提出诊断即组合（DbC）框架，通过学习放射学征象词汇并依据指南组合征象图来诊断和定位未见疾病，在肝脏CT上优于对比方法。
Deep models for radiological diagnosis are typically trained to predict disease labels directly from images, which limits them to diseases seen during training and makes their decisions hard to interpret in radiologists' terms. Radiology, however, proceeds from visual findings to disease through published guidelines that make this decision rule explicit, interpretable, and reproducible. We introduce diagnosis by composition (DbC), a representation learning framework that encodes this findings-first logic. DbC learns a vocabulary of radiological findings by aligning image features with the text embeddings of the findings, each finding represented as a dense map over the scan. A disease is defined by a set of required findings derived from its guidelines, and its diagnosis map is a fixed, parameter-free composition of the corresponding finding maps. Because the finding-to-disease mapping is derived from guidelines rather than learned, DbC is interpretable and auditable by design, can extend to new diseases by specifying their findings without retraining, and can diagnose unseen diseases by composing their findings. On multi-phase liver CT, DbC detects and localizes unseen diseases, rare diseases from a different institution, and an external cohort significantly better than all comparators, including models that align images with disease names. DbC also improves detection and localization in the fully supervised setting and remains superior across training-set sizes. Although demonstrated on liver CT, DbC applies wherever radiological guidelines define diseases through findings.
Zhefan Rao, Meng Chu, Xuan Billy Zhang, Jingfan Chen, Guohao Cai, Runyi Li, Shiyi Du, Xu Huang 等 92 位作者
World Models (WMs) can support Multimodal Agents (MAs) through simulated experience, while Agent trajectories can inform World Model refinement. Evaluating this interaction requires separate evidence about action selection and state evolution. We introduce Dual Exam, which tests Agents under fixed environment response mechanisms and World Models under fixed action interventions across physical, digital, social, and scientific domains. The Agent track compares 10 configurations on 1,088 items in 15 reporting categories. The World Model track contains 400 cases across eight scenarios; 15 configurations have full coverage and one covers six scenarios. GPT 6 Astra leads the case-weighted Agent Index at 31.3, and GPT-Image-2 leads the full-coverage WM Overall at 21.7. These scores use different tasks and metrics and are not directly comparable. A 150-case pilot of one coupled pairing records zero task successes and motivates component-level diagnosis. Results reveal uneven task performance and failures to preserve task-relevant state. Their value for predicting coupled success or sustained reciprocal learning remains to be established.
Pascal Jutras-Dubé, Patrick Pynadath, Jeremy Lu, Yuan Gao, Ruqi Zhang
We introduce sticky jump diffusions (SJDs), continuous-time Markov processes on $\mathbb{R}^d$ whose discrete anchors are token embeddings. In forward time, anchors release their mass at a hazard rate and the released mass diffuses in the continuous ambient space; time reversal couples a score-driven SDE with a sticky jump kernel whose rate and destination are fixed by flux balance with the forward law. We estimate the score and the per-anchor reverse hazards from a single denoising classifier via denoising hazard matching, the hazard analogue of denoising score matching, with simulation-free cross-entropy training. SJD recovers masked diffusion, continuous diffusion, and hybrid diffusion as limits. Its reversal explains features that each family treats as given: the mask of masked diffusion carries no evidence about the source token because the unsticking kernel of every anchor collapses to the same absorbing point; the terminal projection of continuous diffusion is required due to the absence of atoms in its forward marginal, without which flux balance yields no reverse jumps; and the update rules of hybrid diffusion (commit rate, destination, and drift) all follow from flux balance rather than from separate design. Beyond these limits, the unsticking kernel becomes a design space: a cross-position blending corrupts each position toward a blend of its neighbors' clean values or embeddings, turning dependency structure such as spatial locality or a constraint graph into an inductive bias of the corruption itself, and improves over the identity-kernel hybrid on CIFAR-10, Text8, and Sudoku.
Coordinating multiple recommendation objectives (e.g., click and conversion) is critical for real-world generative recommendation (GR). However, since a positive item in GR can be retrieved only when its tokens are successively selected at every decoding step, traditional item-wise methods lack fine-grained token-wise supervision to guide intermediate steps. Motivated by its success in foundation models, we consider introducing multi-objective on-policy distillation (MOPD) into GR to distill two single-objective teachers into a student at each token. Yet, we find that in vanilla MOPD, (i) teachers exhibit unequal distillation difficulty at each token (i.e., token-level imbalance), and (ii) the harder-to-distill teacher varies across tokens (i.e., cross-token inconsistency), leaving each objective poorly learned at certain steps and hindering positive item retrieval for both objectives, leading to suboptimal performance. To address this challenge, we propose KL-MOPD (KL-Weighted Multi-Objective On-Policy Distillation), a simple yet effective distillation method that allocates token-wise teacher weights proportional to the initial student-teacher token-wise KL divergences, thereby strengthening supervision for the harder-to-distill teacher at every decoding step. Despite its simplicity, we theoretically prove that KL-MOPD strictly outperforms vanilla MOPD in the additive joint recommendation objective under mild conditions. Moreover, KL-MOPD is plug-and-play and computationally efficient, requiring only a one-time pre-training weight calibration with negligible training overhead. Extensive experiments on three public benchmarks, a billion-scale industrial dataset, and online A/B tests on our e-commerce advertising platform demonstrate that KL-MOPD significantly improves both individual and joint recommendation performance. The anonymous code is provided for peer review.
Knowledge distillation from large reasoning models (LRMs) often uses raw teacher trajectories as supervision. However, this practice creates a mismatch between the goal of distillation and the nature of teacher trajectories. Advanced LRMs typically improve their reasoning capabilities through reward-driven post-training, such as RLHF. This training optimizes them as strong solvers, rather than as teachers that produce reasoning processes smaller models can easily learn. Since smaller models have different "cognitive capacities" compared to their larger teachers, directly imitating raw teacher trajectories can sometimes be ineffective and often requires a substantial number of high-quality samples. To bridge this mismatch, we propose Cognition-Aligned Reasoning Distillation (CARD), an RL-based framework that transforms solver trajectories into teaching trajectories aligned with the student's cognition. Avoiding expensive resampling, our framework directly transforms existing trajectories. We optimize CARD with two reward signals: (1) a Distribution Alignment Reward that matches the student's predictive distribution, and (2) a Logical Coherence Reward that reduces misleading failed reasoning steps. Comprehensive evaluations across multiple student models and settings demonstrate that CARD outperforms distillation from raw teacher trajectories in in-domain settings while achieving substantial gains in out-of-distribution performance. Code is available at https://github.com/LiteSSLHub/CARD.
Large Language Models (LLMs) have revolutionized various fields, yet their training efficiency is heavily reliant on effective data curation. While data selection has been widely studied, the strategic data organization for enhanced training remains an underexplored area, particularly since current LLMs are often trained for only one or a few epochs. This paper systematically explores the influence of data organization on LLM training by reusing pre-computed sample-level scores originally generated for data efficiency, thereby incurring minimal additional computational overhead. We identify and formalize four key guidances for optimizing data organization: Boundary Sharpening, Cyclic Scheduling, Curriculum Continuity, and Local Diversity. Guided by them, we introduce two novel data ordering methods termed STR and SAW. Extensive experiments across different model scales and data sizes, encompassing both pre-training and SFT stages, validate the effectiveness of our summarized guidances. They also demonstrate the robustness of our proposed data ordering methods in enhancing the stability and performance of LLM training.
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Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) · 2026 · 正式发表