AI 速览：作者构建了覆盖七中心、764例患者的胰腺囊肿MRI公开基准，并提供分割与IPMN风险预测的参考AI模型及联邦学习模拟结果。
Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic cancer precursors, and guideline-based risk stratification both over-treats indolent lesions and misses progression. We present Cyst-X, a public benchmark of 1,461 T1-weighted (T1W) and T2-weighted (T2W) MRI volumes from 764 patients at seven centers, with expert pancreas masks, risk labels, splits and reference AI risk-prediction models. PanSegNet segmented the pancreas with Dice of 86.34% (T1W) and 89.26% (T2W) on held-out centers. For the primary task, high-risk versus low-risk IPMN, a 3D DenseNet-121 achieved cross-validated AUCs of 74.59% and 73.45%; complementary broad binary and three-class tasks reached 78.67--81.28% and 73.47--75.76%. Because patient images often cannot be pooled across institutions, we also simulated federated learning across the seven centers. On T2W MRI, FedProx was similar to centralized training in center-averaged external AUC (71.00% versus 71.18%) but not in pooled AUC (62.35% versus 77.49%). Radiologist comparisons showed cohort-dependent sensitivity--specificity tradeoffs. Cyst-X supports reproducible method development and identifies within-IPMN risk discrimination and cross-center score comparability as open challenges.
Xinyue Xu, Jieqiang Sun, Jing, Dai, Siyuan Chen, Lanjie Ma, Ke Sun, Bin Zhao 等 12 位作者
A dexterous hand succeeds or fails through contact, yet every scalable record of human manipulation (video, vision-based hand tracking, motion capture) observes how the hand moves and misses how it pushes. We present DexCanvas, a hybrid real-synthetic dataset of 7,000 hours of dexterous hand-object interaction with per-frame contact points and contact forces, grown from 70 hours of optical motion capture that spans 21 manipulation types, from power and precision grasps to in-hand manipulation. The forces come from a real-to-sim pipeline: one reinforcement learning (RL) policy, conditioned on object geometry and manipulation type, drives an actuated MANO hand in physics simulation to reproduce each captured object trajectory, and the simulator measures the contacts that produce the reproduced motion. The policy reproduces 87.5% of the demonstrations and still succeeds on 80.9% of rollouts from perturbed initial object poses; these perturbed rollouts expand the 70 captured hours a hundredfold. On six YCB objects absent from the capture set it succeeds 72.5% of the time. The contact channels make better policies: a Diffusion Policy that observes DexCanvas contact features succeeds 82.2% of the time, against 67.5% without them, over 18,522 trials. Contact-driven retargeting carries the same demonstrations to two dexterous robot hands, where the RL stage again produces stable rollouts. A first release of 111,857 force-annotated trajectories is publicly available on Hugging Face.
Fang Wu, Hongbin Lin, Bingchen Duan, Yuchen Wang, Li Erran Li, Yanjie Huang, Mingxuan Cao, Yijun Ma 等 27 位作者
Protein-protein interactions underpin nearly all biological processes. Yet, designing proteins with desired interactions remains challenging due to the structural complexity governing molecular recognition. This study views protein design as a search optimization problem over a combinatorial sequence space under expensive structural evaluation. Toward this goal, we introduce a novel tree-based search framework, ProteoCraft, that employs approximate structural gradients from diffusion-based structure predictors as effective proposal policies to specify where the search should explore. Complete no-gradient inference of folding models separately assigns values to the resulting sequences, determining what is good. ProteoCraft allocates this verification budget through a coarse-to-fine paradigm: multi-site edits first explore distinct sequence basins, then verified promising states undergo strict single-site refinement. Across fourteen de novo binder-design settings spanning eight target proteins, five immune-relevant TCR-facing targets, and four localized CDR redesign tasks, ProteoCraft improves design quality and high-confidence yield. These improvements persist under independent AF2-IG and Rosetta-based interface evaluation. Prospective experimental validation further yielded an 82.9% binding hit rate for PD-L1 miniproteins, with a best measured KD of 0.879 nM, and confirmed binding of designed IFNAR2 VHH. Our code is available at https://github.com/smiles724/ProteoCraft_v1.
Ting-Hsiang Hsu, Bai-Hong Zhou, Qibin Liu, Yue Xu, Shu Li, George Wei-Shu Hou, Benjamin Nachman, Shih-Chieh Hsu 等 11 位作者
Data-intensive collider experiments increasingly require models that transfer across high-dimensional, partially observed measurements, yet most analyses still optimize separate models for each task. Here, to address this bottleneck, we introduce EVENET, an event-level foundation model pretrained on 500 million simulated collision events using self-supervised learning and physics-informed supervision. The model constructs a shared particle-cloud representation from the variable-length set of physics objects in each event. Across searches for heavy resonances and exotic Higgs decays, EVENET outperforms both established and state-of-the-art baselines, particularly in low-statistics regimes. We validate transfer to experimental data by rediscovering the $Υ$ meson in CMS Open Data. The pretrained model also supports precise extraction of quantum-correlation observables that remain stable under the tested systematic variations. Together, these results establish a reusable backbone for diverse collider analyses, improving downstream adaptation after a substantial one-time pretraining investment.
Ziyue Xu, Holger R. Roth, Chester Chen, Peter Cnudde
Federated learning (FL) runtimes standardize aggregation and deployment, but each new study still requires federation formation: selecting task-eligible sites and preparing their local data and task code for federated training or analysis. This preparation recurs when the target changes, while raw records and site-private mappings are excluded from cross-site FL messages. We present FedReady, a system that performs federation formation with bounded LLM agents. Agents propose shared contracts, local adapters, and task code; the runtime owns workflow state and accepts artifacts only after checks tied to their digests. Candidate site discovery prioritizes recall; local eligibility verification checks task support before site admission. Once participating sites and artifacts are fixed, conventional federated training or analysis proceeds without readiness agents. Across 39 simulated retinal sites and four tasks, discovery reaches recall 1.00 at precision 0.65; local eligibility verification removes all 17 false positives without losing an eligible site-task pair. The participating sites supply 45,575 task-record instances and complete four 100-round jobs, including one with a runtime-generated contract. Across ten patient cohorts, preparation supports seven patient populations and holds endpoints at three sources as unsupported. Comparison with manually prepared reference populations and analysis (the manual reference) gives a maximum survival-curve difference of 0.001133. We also analyze 19 development failures, targeted classification ablations, and standalone and heterogeneous agent configurations. These results establish the feasibility of task-specific data preparation before ordinary FL training or analysis.
Xinyue Xu, Hongbin Lin, Juangui Xu, Hualiang Wang, Lehan Wang, Lijie Hu, Adrian Weller, Xiaomeng Li
Medical imaging modalities such as ultrasound and X-ray are widely used in clinical practice, where diagnosis follows a structured, evidence-driven workflow aligned with standardized criteria. While multimodal large language models (MLLMs) show promise for automated medical report generation, most existing systems rely on end-to-end multimodal fusion without modeling clinically defined intermediate attributes, leading to limited grounding and interpretability. To address this issue, we propose CORAL (COncept-grounded ReAsoning with Localization), a multimodal framework that integrates spatial grounding and concept-level supervision into a unified reasoning process. CORAL employs a prompt-driven medical segmentation model to localize lesions and predicts multi-class clinical attributes through a Concept Bottleneck module. The resulting textual concept tokens are combined with mask-modulated visual features within an MLLM to enable structured report generation and diagnostic prediction. Experiments on BUS-CoT and IU X-ray datasets demonstrate consistent improvements in diagnostic accuracy, concept consistency, and report quality over strong general-purpose and medical MLLMs, indicating that concept-grounded reasoning better aligns generation with clinical decision processes.